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GLRA4 glycine receptor alpha 4 (pseudogene) [ Homo sapiens (human) ]

Gene ID: 441509, updated on 23-Nov-2021

Summary

Official Symbol
GLRA4provided by HGNC
Official Full Name
glycine receptor alpha 4 (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:31715
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a glycine receptor and member of the ligand-gated ion channel family of proteins. The encoded protein is missing the fourth transmembrane region compared to related proteins in mouse and rat, and experimental data suggests that the human protein is functionally inactive. However, there is strong evidence to support transcription of this gene. As a result, RefSeq, in collaboration with Ensembl-GENCODE, has determined that this locus is best described as a transcribed pseudogene. [provided by RefSeq, Aug 2019]
Expression
Biased expression in testis (RPKM 1.3), endometrium (RPKM 0.5) and 5 other tissues See more
Orthologs
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Genomic context

See GLRA4 in Genome Data Viewer
Location:
Xq22.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (103705494..103728495, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102960422..102983423, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CNEP1R1 pseudogene 1 Neighboring gene mortality factor 4 like 2 Neighboring gene MORF4L2 antisense RNA 1 Neighboring gene transmembrane protein 31 Neighboring gene uncharacterized LOC107985661 Neighboring gene RAB9B, member RAS oncogene family Neighboring gene proteolipid protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • glycine receptor subunit alpha-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021199.1 RefSeqGene

    Range
    5001..26281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_164162.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049610, Z93848

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    103705494..103728495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024452.2: Suppressed sequence

    Description
    NM_001024452.2: This RefSeq was removed because it is now thought that this gene is a pseudogene.
  2. NM_001172285.1: Suppressed sequence

    Description
    NM_001172285.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
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