MRTO4 MRT4 homolog, ribosome maturation factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: MRTO4provided by HGNC
Official Full Name: MRT4 homolog, ribosome maturation factorprovided by HGNC
Primary source: HGNC:HGNC:18477
See related: Ensembl:ENSG00000053372 MIM:620476; AllianceGenome:HGNC:18477
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRT4; C1orf33; dJ657E11.4
Summary: This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in appendix (RPKM 7.6), lymph node (RPKM 7.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (19251805..19260128)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (19075329..19083650)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (19578299..19586622)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRTO4 Enhances Glycolysis to Facilitate HCC Progression by Inhibiting ALDOB.
Title: MRTO4 Enhances Glycolysis to Facilitate HCC Progression by Inhibiting ALDOB.
Human Mrt4 undergoes phosphorylation in vivo and serines S229, S233, and S235 are phosphorylated by CK2 kinase in vitro.
Title: Molecular behavior of human Mrt4 protein, MRTO4, in stress conditions is regulated by its C-terminal region.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
characterization of Mrt4; findings show Mrt4 is a trans-acting factor involved in ribosome maturation, with nucleus-cytoplasm shuttling capacity
Title: Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

SHGC-74311 (e-PCR)
- UniSTS:29206

D8S2279 (e-PCR)
- UniSTS:473907

RH101990 (e-PCR)
- UniSTS:96324

MARC_6491-6492:996689696:1 (e-PCR)
- UniSTS:269661

GDB:631802 (e-PCR)
- UniSTS:158429

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit assembly	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mRNA turnover protein 4 homolog

Names: 60S acidic ribosomal protein PO; MRT4, mRNA turnover 4, homolog; MRTO4 ribosome maturation factor; mRNA turnover 4 homolog; ribosome assembly factor MRTO4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016183.4 → NP_057267.2 mRNA turnover protein 4 homolog

See identical proteins and their annotated locations for NP_057267.2

Status: REVIEWED

Source sequence(s)

AL035413, AY303790, BQ670859

Consensus CDS

CCDS191.1

UniProtKB/Swiss-Prot

B3KNB3, Q5TG55, Q96SS6, Q9BPV9, Q9UKD2

Related

ENSP00000364320.3, ENST00000330263.5

Conserved Domains (1) summary

cd05796
Location:21 → 183

Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

19251805..19260128

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006710675.5 → XP_006710738.1 mRNA turnover protein 4 homolog isoform X1

See identical proteins and their annotated locations for XP_006710738.1

Conserved Domains (1) summary

cd05796
Location:1 → 136

Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...