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MRTO4 MRT4 homolog, ribosome maturation factor [ Homo sapiens (human) ]

Gene ID: 51154, updated on 7-Oct-2018

Summary

Official Symbol
MRTO4provided by HGNC
Official Full Name
MRT4 homolog, ribosome maturation factorprovided by HGNC
Primary source
HGNC:HGNC:18477
See related
Ensembl:ENSG00000053372 Vega:OTTHUMG00000002496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRT4; C1orf33; dJ657E11.4
Summary
This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 7.6), lymph node (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See MRTO4 in Genome Data Viewer
Location:
1p36.13
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (19251581..19260128)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19578075..19586622)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3 component n-recognin 4 Neighboring gene EMC1 antisense RNA 1 Neighboring gene ER membrane protein complex subunit 1 Neighboring gene aldo-keto reductase family 7 like (gene/pseudogene) Neighboring gene uncharacterized LOC100506730 Neighboring gene aldo-keto reductase family 7 member A3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mRNA turnover protein 4 homolog
Names
60S acidic ribosomal protein PO
MRT4, mRNA turnover 4, homolog
MRTO4 ribosome maturation factor
mRNA turnover 4 homolog
ribosome assembly factor MRTO4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016183.3NP_057267.2  mRNA turnover protein 4 homolog

    See identical proteins and their annotated locations for NP_057267.2

    Status: REVIEWED

    Source sequence(s)
    AL035413, AY303790, BP312953, BQ670859
    Consensus CDS
    CCDS191.1
    UniProtKB/Swiss-Prot
    Q9UKD2
    UniProtKB/TrEMBL
    A0A024RAE1
    Related
    ENSP00000364320.3, OTTHUMP00000002580, ENST00000330263.4, OTTHUMT00000007075
    Conserved Domains (1) summary
    cd05796
    Location:21183
    Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    19251581..19260128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710675.4XP_006710738.1  mRNA turnover protein 4 homolog isoform X1

    See identical proteins and their annotated locations for XP_006710738.1

    Conserved Domains (1) summary
    cd05796
    Location:1136
    Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...
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