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RDH11 retinol dehydrogenase 11 [ Homo sapiens (human) ]

Gene ID: 51109, updated on 12-Aug-2018

Summary

Official Symbol
RDH11provided by HGNC
Official Full Name
retinol dehydrogenase 11provided by HGNC
Primary source
HGNC:HGNC:17964
See related
Ensembl:ENSG00000072042 MIM:607849; Vega:OTTHUMG00000171196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDT1; CGI82; PSDR1; RALR1; SCALD; ARSDR1; HCBP12; RDJCSS; SDR7C1
Summary
The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]
Expression
Biased expression in prostate (RPKM 353.6), kidney (RPKM 48.4) and 9 other tissues See more
Orthologs

Genomic context

See RDH11 in Genome Data Viewer
Location:
14q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (67676800..67695793, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (68143517..68162510, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene gephyrin Neighboring gene RNA, 5S ribosomal pseudogene 386 Neighboring gene cytochrome c oxidase subunit 7A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 369, pseudogene Neighboring gene vesicle transport through interaction with t-SNAREs 1B Neighboring gene ribosomal protein L21 pseudogene 9 Neighboring gene retinol dehydrogenase 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of retinol dehydrogenase 11 (RDH11) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of fat-soluble vitamins, organism-specific biosystem (from REACTOME)
    Metabolism of fat-soluble vitamins, organism-specific biosystemVitamins A, D, E, and K are classified as fat-soluble. Metabolic pathways by which dietary precursors of vitamins A (Harrison 2005) and K(Shearer et al. 2012) are converted to active forms, and by wh...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • RA biosynthesis pathway, organism-specific biosystem (from REACTOME)
    RA biosynthesis pathway, organism-specific biosystemThe major activated retinoid, all-trans-retinoic acid (atRA) is produced by the dehydrogenation of all-trans-retinol (atROL) by members of the short chain dehydrogenase/reductase (SDR) and aldehyde d...
  • Retinoid metabolism and transport, organism-specific biosystem (from REACTOME)
    Retinoid metabolism and transport, organism-specific biosystemVitamin A (all-trans-retinol) must be taken up, either as carotenes from plants, or as retinyl esters from animal food. The most prominent carotenes are alpha-carotene, lycopene, lutein, beta-cryptox...
  • Retinol metabolism, organism-specific biosystem (from KEGG)
    Retinol metabolism, organism-specific biosystem
    Retinol metabolism
  • Retinol metabolism, conserved biosystem (from KEGG)
    Retinol metabolism, conserved biosystem
    Retinol metabolism
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Retinoic Acid, organism-specific biosystem (from REACTOME)
    Signaling by Retinoic Acid, organism-specific biosystemVitamin A (retinol) can be metabolised into active retinoid metabolites that function either as a chromophore in vision or in regulating gene expression transcriptionally and post-transcriptionally. ...
  • The canonical retinoid cycle in rods (twilight vision), organism-specific biosystem (from REACTOME)
    The canonical retinoid cycle in rods (twilight vision), organism-specific biosystemThe retinoid cycle (also referred to as the visual cycle) is the process by which the visual chromophore 11-cis-retinal (11cRAL) is released from light-activated opsins in the form all-trans-retinal ...
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...
  • retinol biosynthesis, conserved biosystem (from BIOCYC)
    retinol biosynthesis, conserved biosystemGeneral Background Vitamin A is the name given to a family of related compounds from the |FRAME: Retinoids retinoid| group, including all-trans forms such as |FRAME: CPD-13524|, |FRAME: RETINAL| and...
  • retinol biosynthesis, organism-specific biosystem (from BIOCYC)
    retinol biosynthesis, organism-specific biosystem
    retinol biosynthesis
  • the visual cycle I (vertebrates), conserved biosystem (from BIOCYC)
    the visual cycle I (vertebrates), conserved biosystemGeneral background The source of the chromophore in the visual system is |FRAME: CPD-13524|, derived from the blood circulation (see |FRAME: PWY-6857| for its synthesis). The compound is taken up fr...
  • the visual cycle I (vertebrates), organism-specific biosystem (from BIOCYC)
    the visual cycle I (vertebrates), organism-specific biosystem
    the visual cycle I (vertebrates)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: VTI1B

Homology

Clone Names

  • FLJ32633

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP-retinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
NADP-retinol dehydrogenase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinol dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
retinol dehydrogenase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
adaptation of rhodopsin mediated signaling IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
retinol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular ISS
Inferred from Sequence or Structural Similarity
more info
 
photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retinol dehydrogenase 11
Names
HCV core-binding protein HCBP12
androgen-regulated short-chain dehydrogenase/reductase 1
prostate short-chain dehydrogenase reductase 1
retinal reductase 1
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
short chain dehydrogenase/reductase family 7C, member 1
NP_001239579.1
NP_057110.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042282.1 RefSeqGene

    Range
    5001..23994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252650.1NP_001239579.1  retinol dehydrogenase 11 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI382141, AK293355, AL049779, DC355364
    Consensus CDS
    CCDS58326.1
    UniProtKB/Swiss-Prot
    Q8TC12
    Related
    ENSP00000416395.2, OTTHUMP00000245405, ENST00000428130.6, OTTHUMT00000412260
    Conserved Domains (2) summary
    PRK06197
    Location:41244
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:41239
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_016026.3NP_057110.3  retinol dehydrogenase 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057110.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF167438, BC011727, DC355364
    Consensus CDS
    CCDS32104.1
    UniProtKB/Swiss-Prot
    Q8TC12
    UniProtKB/TrEMBL
    A0A0S2Z583
    Related
    ENSP00000370750.4, OTTHUMP00000245403, ENST00000381346.8, OTTHUMT00000412257
    Conserved Domains (2) summary
    PRK06197
    Location:41314
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:41309
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    67676800..67695793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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