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RDH11 retinol dehydrogenase 11 [ Homo sapiens (human) ]

Gene ID: 51109, updated on 13-Mar-2020

Summary

Official Symbol
RDH11provided by HGNC
Official Full Name
retinol dehydrogenase 11provided by HGNC
Primary source
HGNC:HGNC:17964
See related
Ensembl:ENSG00000072042 MIM:607849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDT1; CGI82; PSDR1; RALR1; SCALD; ARSDR1; HCBP12; RDJCSS; SDR7C1
Summary
The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]
Expression
Biased expression in prostate (RPKM 353.6), kidney (RPKM 48.4) and 9 other tissues See more
Orthologs

Genomic context

See RDH11 in Genome Data Viewer
Location:
14q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (67676800..67695764, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (68143517..68162510, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs 1B Neighboring gene cytochrome c oxidase subunit 7A2 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 386 Neighboring gene Sharpr-MPRA regulatory region 4541 Neighboring gene RNA, 7SL, cytoplasmic 369, pseudogene Neighboring gene retinol dehydrogenase 12 Neighboring gene ribosomal protein L21 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of retinol dehydrogenase 11 (RDH11) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: VTI1B

Homology

Clone Names

  • FLJ32633

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP-retinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinol dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular detoxification of aldehyde IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
retinol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retinol dehydrogenase 11
Names
HCV core-binding protein HCBP12
androgen-regulated short-chain dehydrogenase/reductase 1
prostate short-chain dehydrogenase reductase 1
retinal reductase 1
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
short chain dehydrogenase/reductase family 7C, member 1
NP_001239579.1
NP_057110.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042282.1 RefSeqGene

    Range
    5030..23994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252650.2NP_001239579.1  retinol dehydrogenase 11 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI382141, AK293355, AL049779, DC355364
    Consensus CDS
    CCDS58326.1
    UniProtKB/Swiss-Prot
    Q8TC12
    Related
    ENSP00000416395.2, ENST00000428130.6
    Conserved Domains (2) summary
    PRK06197
    Location:41244
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:41239
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_016026.4NP_057110.3  retinol dehydrogenase 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057110.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF167438, BC011727, DC355364
    Consensus CDS
    CCDS32104.1
    UniProtKB/Swiss-Prot
    Q8TC12
    UniProtKB/TrEMBL
    A0A0S2Z583
    Related
    ENSP00000370750.4, ENST00000381346.9
    Conserved Domains (2) summary
    PRK06197
    Location:41314
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:41309
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    67676800..67695764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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