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VTI1B vesicle transport through interaction with t-SNAREs 1B [ Homo sapiens (human) ]

Gene ID: 10490, updated on 6-Jan-2019

Summary

Official Symbol
VTI1Bprovided by HGNC
Official Full Name
vesicle transport through interaction with t-SNAREs 1Bprovided by HGNC
Primary source
HGNC:HGNC:17793
See related
Ensembl:ENSG00000100568 MIM:603207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE
Expression
Ubiquitous expression in fat (RPKM 68.1), kidney (RPKM 45.6) and 25 other tissues See more
Orthologs

Genomic context

See VTI1B in Genome Data Viewer
Location:
14q24.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (67651149..67674885, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (68113621..68141700, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene gephyrin Neighboring gene uncharacterized LOC105370543 Neighboring gene protein kinase C eta pseudogene Neighboring gene high mobility group box 1 pseudogene 34 Neighboring gene RNA, 5S ribosomal pseudogene 386 Neighboring gene cytochrome c oxidase subunit 7A2 pseudogene 1 Neighboring gene arginase 2 Neighboring gene RNA, 7SL, cytoplasmic 369, pseudogene Neighboring gene retinol dehydrogenase 11 Neighboring gene retinol dehydrogenase 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag co-localizes with the endosomal SNARE proteins Vti1b and syntaxin 8 in HPS2 fibroblasts PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane fusion TAS
Traceable Author Statement
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle docking involved in exocytosis TAS
Traceable Author Statement
more info
PubMed 
vesicle fusion with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vesicle transport through interaction with t-SNAREs homolog 1B
Names
vesicle transport v-SNARE protein Vti1-like 1
vesicle-associated soluble NSF attachment protein receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006370.3NP_006361.1  vesicle transport through interaction with t-SNAREs homolog 1B

    See identical proteins and their annotated locations for NP_006361.1

    Status: VALIDATED

    Source sequence(s)
    AL049779, BC003142
    Consensus CDS
    CCDS9786.1
    UniProtKB/Swiss-Prot
    Q9UEU0
    Related
    ENSP00000450731.1, ENST00000554659.5
    Conserved Domains (2) summary
    cd15890
    Location:136197
    SNARE_Vti1b; SNARE motif of Vti1b-like
    pfam05008
    Location:1896
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    67651149..67674885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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