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Rdh11 retinol dehydrogenase 11 [ Mus musculus (house mouse) ]

Gene ID: 17252, updated on 3-Jun-2026
Official Symbol
Rdh11provided by MGI
Official Full Name
retinol dehydrogenase 11provided by MGI
Primary source
MGI:MGI:102581
See related
Ensembl:ENSMUSG00000066441 AllianceGenome:MGI:102581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mdt1; Psdr1; SCALD; ralR1; Arsdr1; CGI-82; HCBP12; M42C60; Ube-1c; UBE-1c1; 2610319N22Rik
Summary
Enables aldehyde dehydrogenase (NADP+) activity. Involved in cellular detoxification of aldehyde; retinol metabolic process; and visual perception. Located in photoreceptor inner segment. Is expressed in eye and forebrain. Orthologous to human RDH11 (retinol dehydrogenase 11). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in testis adult (RPKM 59.5), liver E18 (RPKM 35.6) and 22 other tissues See more
Orthologs
all
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See Rdh11 in Genome Data Viewer
Location:
12 C3; 12 35.51 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (79221007..79238629, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (79174233..79191855, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene arginase type II Neighboring gene predicted gene, 40462 Neighboring gene vesicle transport through interaction with t-SNAREs 1B Neighboring gene STARR-positive B cell enhancer ABC_E10761 Neighboring gene STARR-positive B cell enhancer ABC_E11514 Neighboring gene retinol dehydrogenase 12 Neighboring gene zinc finger, FYVE domain containing 26 Neighboring gene STARR-seq mESC enhancer starr_32594 Neighboring gene STARR-positive B cell enhancer ABC_E920

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. Kim TS, et al. J Biol Chem, 2005 Mar 11. PMID 15634683, Free PMC Article
  2. Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo. Kasus-Jacobi A, et al. J Biol Chem, 2005 May 27. PMID 15790565
  3. Photoreceptor retinol dehydrogenases. An attempt to characterize the function of Rdh11. Kasus-Jacobi A, et al. Adv Exp Med Biol, 2006. PMID 17249616
  4. Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Maeda A, et al. Invest Ophthalmol Vis Sci, 2006 Oct. PMID 17003450, Free PMC Article
  5. Isolation and characterization of the murine prostate short-chain dehydrogenase/reductase 1 (Psdr1) gene, a new member of the short-chain steroid dehydrogenase/reductase family. Moore S, et al. Gene, 2002 Jun 26. PMID 12137953

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicate that in mouse testis and liver, RDH11 functions as an all-trans-retinaldehyde reductase essential for the maintenance of physiological levels of all-trans-retinol under reduced vitamin A availability
    Title: Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in mice.
  2. Oxidative stress induced by exposure to constant bright light led to a rapid and significant decrease of RDH12 protein. The low and constant expression of RDH11 suggested a housekeeping function for this enzyme.
    Title: Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress.
  3. RDH11 has a measurable role in regenerating the visual pigment by complementing RDH5 in retinal pigment epithelium.
    Title: Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo.
  4. propose that mouse retinol dehydrogenase 11(mRDH11) disruption affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptation through modulation of calcium homeostasis
    Title: Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo.
  5. characterization of catalytic properties and tissue distribution
    Title: Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins.
  6. RDH11 localizes to photoreceptor inner segments [review]
    Title: Photoreceptor retinol dehydrogenases. An attempt to characterize the function of Rdh11.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 11-cis-retinol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables 11-cis-retinol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables 11-cis-retinol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables aldehyde dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables all-trans-retinol dehydrogenase (NADP+) activity EXP
Inferred from Experiment
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables all-trans-retinol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular detoxification of aldehyde IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular detoxification of aldehyde IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular detoxification of aldehyde ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinal metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in retinoid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in retinol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in visual perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
retinol dehydrogenase 11
Names
all-trans and 9-cis
androgen-regulated short-chain dehydrogenase/reductase 1
cell line MC/9.IL4 derived transcript 1
cell line MC/9.IL4-derived protein 1
prostate short-chain dehydrogenase/reductase 1
retinal reductase 1
short-chain aldehyde dehydrogenase
NP_001349198.1
NP_001349199.1
NP_067532.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362269.1 → NP_001349198.1  retinol dehydrogenase 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154585
    Consensus CDS
    CCDS88359.1
    UniProtKB/TrEMBL
    Q9R1R8, Q9R1R9
    Related
    ENSMUSP00000082352.7, ENSMUST00000085254.7
    Conserved Domains (1) summary
    cl25409
    Location:22 → 290
    SDR; Short-chain dehydrogenases/reductases (SDR)

  2. NM_001362270.1 → NP_001349199.1  retinol dehydrogenase 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154585
    UniProtKB/TrEMBL
    Q9R1R5
    Conserved Domains (1) summary
    cl25409
    Location:1 → 179
    SDR; Short-chain dehydrogenases/reductases (SDR)

  3. NM_021557.6 → NP_067532.2  retinol dehydrogenase 11 isoform 1

    See identical proteins and their annotated locations for NP_067532.2

    Status: VALIDATED

    Source sequence(s)
    AK004413, AK135443, BU053368
    Consensus CDS
    CCDS36480.1
    UniProtKB/Swiss-Prot
    Q3UXM9, Q9D0U5, Q9QYF1
    UniProtKB/TrEMBL
    Q9R1R9
    Related
    ENSMUSP00000124066.2, ENSMUST00000161204.8
    Conserved Domains (2) summary
    PRK06197
    Location:38 → 311
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:38 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    79221007..79238629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYF1.2 GenPept UniProtKB/Swiss-Prot:Q9QYF1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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