Format

Send to:

Choose Destination

PCM1 pericentriolar material 1 [ Homo sapiens (human) ]

Gene ID: 5108, updated on 4-Nov-2018

Summary

Official Symbol
PCM1provided by HGNC
Official Full Name
pericentriolar material 1provided by HGNC
Primary source
HGNC:HGNC:8727
See related
Ensembl:ENSG00000078674 MIM:600299; Vega:OTTHUMG00000163699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTC4; RET/PCM-1
Summary
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Broad expression in testis (RPKM 47.5), thyroid (RPKM 18.5) and 25 other tissues See more
Orthologs

Genomic context

See PCM1 in Genome Data Viewer
Location:
8p22
Exon count:
46
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (17922784..18029948)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17780364..17887457)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microtubule associated scaffold protein 1 Neighboring gene uncharacterized LOC101930275 Neighboring gene fibrinogen like 1 Neighboring gene uncharacterized LOC101929066 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene mitochondrial ribosomal protein S18C pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
    AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
  • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
    Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
  • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
    Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
  • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
    Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
interkinetic nuclear migration ISS
Inferred from Sequence or Structural Similarity
more info
 
intraciliary transport involved in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intraciliary transport involved in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule anchoring ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
social behavior IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary transition zone IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
NOT non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
pericentriolar material ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pericentriolar material 1 protein
Names
PCM-1
hPCM-1
pericentriolar material 1, PCM1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027690.1 RefSeqGene

    Range
    5001..112092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001315507.1NP_001302436.1  pericentriolar material 1 protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC087273, AC087625, AW237120, BC140946
    Consensus CDS
    CCDS83256.1
    UniProtKB/TrEMBL
    B9EIS5
    Related
    ENSP00000431099.1, OTTHUMP00000224569, ENST00000519253.5, OTTHUMT00000374800
    Conserved Domains (1) summary
    pfam15717
    Location:13721990
    PCM1_C; Pericentriolar material 1 C terminus
  2. NM_001315508.1NP_001302437.1  pericentriolar material 1 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame segments compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC087273, AC087625, AW237120, BC133052, BP282954, L27841
    Consensus CDS
    CCDS83255.1
    UniProtKB/Swiss-Prot
    Q15154
    UniProtKB/TrEMBL
    A2RUU9
    Related
    ENSP00000328332.9, ENST00000327578.9
    Conserved Domains (1) summary
    pfam15717
    Location:13181834
    PCM1_C; Pericentriolar material 1 C terminus
  3. NM_001352632.1NP_001339561.1  pericentriolar material 1 protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:14112041
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001352633.1NP_001339562.1  pericentriolar material 1 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:14182036
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001352634.1NP_001339563.1  pericentriolar material 1 protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13722002
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  6. NM_001352635.1NP_001339564.1  pericentriolar material 1 protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13731991
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  7. NM_001352636.1NP_001339565.1  pericentriolar material 1 protein isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13571983
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001352637.1NP_001339566.1  pericentriolar material 1 protein isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13561982
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001352638.1NP_001339567.1  pericentriolar material 1 protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13561974
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  10. NM_001352639.1NP_001339568.1  pericentriolar material 1 protein isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171947
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  11. NM_001352640.1NP_001339569.1  pericentriolar material 1 protein isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13181944
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  12. NM_001352641.1NP_001339570.1  pericentriolar material 1 protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171939
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  13. NM_001352642.1NP_001339571.1  pericentriolar material 1 protein isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171833
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  14. NM_001352643.1NP_001339572.1  pericentriolar material 1 protein isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:14111509
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  15. NM_001352644.1NP_001339573.1  pericentriolar material 1 protein isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform 16.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171943
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  16. NM_001352645.1NP_001339574.1  pericentriolar material 1 protein isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform 16.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171943
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  17. NM_001352646.1NP_001339575.1  pericentriolar material 1 protein isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform 17.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171935
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  18. NM_001352647.1NP_001339576.1  pericentriolar material 1 protein isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform 17.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171935
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  19. NM_001352648.1NP_001339577.1  pericentriolar material 1 protein isoform 18

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform 18.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13181936
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  20. NM_001352649.1NP_001339578.1  pericentriolar material 1 protein isoform 18

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform 18.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13181936
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  21. NM_001352650.1NP_001339579.1  pericentriolar material 1 protein isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variant 23, encodes isoform 19.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:14112037
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  22. NM_001352651.1NP_001339580.1  pericentriolar material 1 protein isoform 19

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variant 22, encodes isoform 19.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:14112037
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  23. NM_001352652.1NP_001339581.1  pericentriolar material 1 protein isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variant 25, encodes isoform 20.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Consensus CDS
    CCDS47812.1
    Conserved Domains (2) summary
    pfam15717
    Location:13721998
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  24. NM_001352653.1NP_001339582.1  pericentriolar material 1 protein isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variant 24, encodes isoform 20.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Consensus CDS
    CCDS47812.1
    Conserved Domains (2) summary
    pfam15717
    Location:13721998
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  25. NM_001352654.1NP_001339583.1  pericentriolar material 1 protein isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 27 and 28, encodes isoform 21.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171415
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231447
    DUF4175; Domain of unknown function (DUF4175)
  26. NM_001352655.1NP_001339584.1  pericentriolar material 1 protein isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 26 and 28, encodes isoform 21.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171415
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231447
    DUF4175; Domain of unknown function (DUF4175)
  27. NM_001352656.1NP_001339585.1  pericentriolar material 1 protein isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 26 and 27, encodes isoform 21.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13171415
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231447
    DUF4175; Domain of unknown function (DUF4175)
  28. NM_001352657.1NP_001339586.1  pericentriolar material 1 protein isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variant 30, encodes isoform 22.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13721470
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  29. NM_001352658.1NP_001339587.1  pericentriolar material 1 protein isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variant 29, encodes isoform 22.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Conserved Domains (2) summary
    pfam15717
    Location:13721470
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  30. NM_001352659.1NP_001339588.1  pericentriolar material 1 protein isoform 23

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variant 32, encodes isoform 23.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Consensus CDS
    CCDS87582.1
    Related
    ENSP00000428123.1, ENST00000518537.5
    Conserved Domains (1) summary
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  31. NM_001352660.1NP_001339589.1  pericentriolar material 1 protein isoform 23

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variant 31, encodes isoform 23.
    Source sequence(s)
    AC087273, AC087625, BC065022
    Consensus CDS
    CCDS87582.1
    Conserved Domains (1) summary
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  32. NM_006197.3NP_006188.3  pericentriolar material 1 protein isoform 1

    See identical proteins and their annotated locations for NP_006188.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC087273, AC087625, AW237120, BC133052, L27841
    Consensus CDS
    CCDS47812.1
    UniProtKB/Swiss-Prot
    Q15154
    UniProtKB/TrEMBL
    A2RUU9
    Related
    ENSP00000327077.8, OTTHUMP00000224566, ENST00000325083.12, OTTHUMT00000374793
    Conserved Domains (2) summary
    pfam15717
    Location:13721998
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)

RNA

  1. NR_148032.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC087273, AC087625, BC065022

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    17922784..18029948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544528.2XP_011542830.1  pericentriolar material 1 protein isoform X1

    See identical proteins and their annotated locations for XP_011542830.1

    Conserved Domains (1) summary
    pfam15717
    Location:15012131
    PCM1_C; Pericentriolar material 1 C terminus
  2. XM_011544534.2XP_011542836.1  pericentriolar material 1 protein isoform X4

    Conserved Domains (2) summary
    pfam02463
    Location:226883
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam15717
    Location:15012123
    PCM1_C; Pericentriolar material 1 C terminus
  3. XM_006716336.3XP_006716399.1  pericentriolar material 1 protein isoform X3

    Conserved Domains (2) summary
    pfam02463
    Location:226883
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam15717
    Location:14942124
    PCM1_C; Pericentriolar material 1 C terminus
  4. XM_006716340.3XP_006716403.1  pericentriolar material 1 protein isoform X5

    Conserved Domains (2) summary
    pfam02463
    Location:226883
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam15717
    Location:14942120
    PCM1_C; Pericentriolar material 1 C terminus
  5. XM_011544532.2XP_011542834.1  pericentriolar material 1 protein isoform X2

    Conserved Domains (1) summary
    pfam15717
    Location:15002130
    PCM1_C; Pericentriolar material 1 C terminus
  6. XM_024447168.1XP_024302936.1  pericentriolar material 1 protein isoform X8

    Conserved Domains (2) summary
    pfam15717
    Location:14112037
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_017013486.1XP_016868975.1  pericentriolar material 1 protein isoform X12

  8. XM_024447171.1XP_024302939.1  pericentriolar material 1 protein isoform X14

    Conserved Domains (2) summary
    pfam15717
    Location:13561974
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  9. XM_024447169.1XP_024302937.1  pericentriolar material 1 protein isoform X11

    Conserved Domains (2) summary
    pfam15717
    Location:13731991
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
  10. XM_017013491.1XP_016868980.1  pericentriolar material 1 protein isoform X15

  11. XM_017013480.1XP_016868969.1  pericentriolar material 1 protein isoform X10

  12. XM_024447167.1XP_024302935.1  pericentriolar material 1 protein isoform X1

    Conserved Domains (1) summary
    pfam15717
    Location:15012131
    PCM1_C; Pericentriolar material 1 C terminus
  13. XM_011544529.2XP_011542831.1  pericentriolar material 1 protein isoform X1

    See identical proteins and their annotated locations for XP_011542831.1

    Conserved Domains (1) summary
    pfam15717
    Location:15012131
    PCM1_C; Pericentriolar material 1 C terminus
  14. XM_011544530.2XP_011542832.1  pericentriolar material 1 protein isoform X1

    See identical proteins and their annotated locations for XP_011542832.1

    Conserved Domains (1) summary
    pfam15717
    Location:15012131
    PCM1_C; Pericentriolar material 1 C terminus
  15. XM_017013472.1XP_016868961.1  pericentriolar material 1 protein isoform X6

    Conserved Domains (1) summary
    pfam15717
    Location:14382068
    PCM1_C; Pericentriolar material 1 C terminus
  16. XM_017013473.1XP_016868962.1  pericentriolar material 1 protein isoform X7

    Conserved Domains (1) summary
    pfam15717
    Location:14372067
    PCM1_C; Pericentriolar material 1 C terminus
  17. XM_017013478.1XP_016868967.1  pericentriolar material 1 protein isoform X9

  18. XM_017013489.1XP_016868978.1  pericentriolar material 1 protein isoform X13

  19. XM_017013481.1XP_016868970.1  pericentriolar material 1 protein isoform X10

  20. XM_017013493.1XP_016868982.1  pericentriolar material 1 protein isoform X16

  21. XM_017013490.2XP_016868979.1  pericentriolar material 1 protein isoform X14

    Conserved Domains (2) summary
    pfam15717
    Location:13561974
    PCM1_C; Pericentriolar material 1 C terminus
    cl25732
    Location:226463
    SMC_N; RecF/RecN/SMC N terminal domain
  22. XM_017013501.1XP_016868990.1  pericentriolar material 1 protein isoform X18

  23. XM_017013496.2XP_016868985.1  pericentriolar material 1 protein isoform X17

  24. XM_024447170.1XP_024302938.1  pericentriolar material 1 protein isoform X11

    Conserved Domains (2) summary
    pfam15717
    Location:13731991
    PCM1_C; Pericentriolar material 1 C terminus
    cl25736
    Location:231450
    DUF4175; Domain of unknown function (DUF4175)
Support Center