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Pcm1 pericentriolar material 1 [ Mus musculus (house mouse) ]

Gene ID: 18536, updated on 6-Jun-2024

Summary

Official Symbol
Pcm1provided by MGI
Official Full Name
pericentriolar material 1provided by MGI
Primary source
MGI:MGI:1277958
See related
Ensembl:ENSMUSG00000031592 AllianceGenome:MGI:1277958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600002H09Rik; 9430077F19Rik; C030044G17Rik
Summary
Involved in microtubule anchoring and negative regulation of neurogenesis. Acts upstream of or within several processes, including microtubule anchoring at centrosome; nervous system development; and neuronal stem cell population maintenance. Located in apical part of cell; cytoplasm; and microtubule organizing center. Colocalizes with centrosome. Is expressed in brain; cardiac muscle tissue; and cerebral cortex ventricular layer. Orthologous to human PCM1 (pericentriolar material 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 13.4), CNS E14 (RPKM 11.0) and 20 other tissues See more
Orthologs
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Genomic context

See Pcm1 in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41692521..41787125)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (41239484..41334088)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21287 Neighboring gene fibrinogen-like protein 1 Neighboring gene predicted gene 16348 Neighboring gene STARR-seq mESC enhancer starr_21288 Neighboring gene STARR-seq mESC enhancer starr_21289 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene STARR-seq mESC enhancer starr_21290 Neighboring gene STARR-positive B cell enhancer ABC_E1364 Neighboring gene FSHD region gene 1 Neighboring gene predicted gene, 50494

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC170660

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within interkinetic nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intraciliary transport involved in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intraciliary transport involved in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule anchoring IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within microtubule anchoring at centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex localization to centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein complex stability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
pericentriolar material 1 protein
Names
PCM-1
mPCM-1
pericentriolar material gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403817.1NP_001390746.1  pericentriolar material 1 protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554
    UniProtKB/TrEMBL
    B2RSW8
    Related
    ENSMUSP00000147887.2, ENSMUST00000211247.2
  2. NM_001403819.1NP_001390748.1  pericentriolar material 1 protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554
    UniProtKB/TrEMBL
    B2RSW8
  3. NM_001403820.1NP_001390749.1  pericentriolar material 1 protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554
    UniProtKB/TrEMBL
    B2RSW8
  4. NM_001403823.1NP_001390752.1  pericentriolar material 1 protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554
    UniProtKB/TrEMBL
    B2RSW8
  5. NM_001403824.1NP_001390753.1  pericentriolar material 1 protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554
    UniProtKB/TrEMBL
    B2RSW8
  6. NM_001403825.1NP_001390754.1  pericentriolar material 1 protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554
    UniProtKB/TrEMBL
    B2RSW8
  7. NM_023662.4NP_076151.2  pericentriolar material 1 protein isoform 4

    See identical proteins and their annotated locations for NP_076151.2

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554
    Consensus CDS
    CCDS22261.1
    UniProtKB/Swiss-Prot
    E9QLK2, O70287, Q3URH6, Q7TMS7, Q8C9V2, Q91Y27, Q91Y28, Q91Y51, Q923L0, Q9CRK8, Q9CT57, Q9R0L6
    UniProtKB/TrEMBL
    B2RSW8
    Related
    ENSMUSP00000039709.8, ENSMUST00000045218.9
    Conserved Domains (1) summary
    pfam15717
    Location:13691999
    PCM1_C; Pericentriolar material 1 C terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    41692521..41787125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153815.1XP_036009708.1  pericentriolar material 1 protein isoform X1

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:14152045
    PCM1_C; Pericentriolar material 1 C-terminus
  2. XM_036153818.1XP_036009711.1  pericentriolar material 1 protein isoform X6

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:14152000
    PCM1_C; Pericentriolar material 1 C-terminus
  3. XM_006509300.3XP_006509363.1  pericentriolar material 1 protein isoform X7

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:14081993
    PCM1_C; Pericentriolar material 1 C-terminus
  4. XM_006509301.3XP_006509364.1  pericentriolar material 1 protein isoform X9

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (2) summary
    COG1196
    Location:229463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:13531983
    PCM1_C; Pericentriolar material 1 C-terminus
  5. XM_036153819.1XP_036009712.1  pericentriolar material 1 protein isoform X8

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (2) summary
    COG1196
    Location:229463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:13571987
    PCM1_C; Pericentriolar material 1 C-terminus
  6. XM_036153817.1XP_036009710.1  pericentriolar material 1 protein isoform X4

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:13762006
    PCM1_C; Pericentriolar material 1 C-terminus
  7. XM_036153822.1XP_036009715.1  pericentriolar material 1 protein isoform X13

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:13691954
    PCM1_C; Pericentriolar material 1 C-terminus
  8. XM_036153823.1XP_036009716.1  pericentriolar material 1 protein isoform X14

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:13181948
    PCM1_C; Pericentriolar material 1 C-terminus
  9. XM_036153824.1XP_036009717.1  pericentriolar material 1 protein isoform X16

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:13111941
    PCM1_C; Pericentriolar material 1 C-terminus
  10. XM_036153816.1XP_036009709.1  pericentriolar material 1 protein isoform X3

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:13822012
    PCM1_C; Pericentriolar material 1 C-terminus
  11. XM_036153821.1XP_036009714.1  pericentriolar material 1 protein isoform X12

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:13751960
    PCM1_C; Pericentriolar material 1 C-terminus
  12. XM_036153820.1XP_036009713.1  pericentriolar material 1 protein isoform X11

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:13431973
    PCM1_C; Pericentriolar material 1 C-terminus