Pcm1 pericentriolar material 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcm1provided by MGI
Official Full Name: pericentriolar material 1provided by MGI
Primary source: MGI:MGI:1277958
See related: Ensembl:ENSMUSG00000031592 AllianceGenome:MGI:1277958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2600002H09Rik; 9430077F19Rik; C030044G17Rik
Summary: Involved in microtubule anchoring and negative regulation of neurogenesis. Acts upstream of or within several processes, including microtubule anchoring at centrosome; nervous system development; and neuronal stem cell population maintenance. Located in apical part of cell; cytoplasm; and microtubule organizing center. Colocalizes with centrosome. Is expressed in brain; cardiac muscle tissue; and cerebral cortex ventricular layer. Orthologous to human PCM1 (pericentriolar material 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 13.4), CNS E14 (RPKM 11.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 23.89 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (41692521..41787125)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (41239484..41334088)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
Title: PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
MicroRNA (miR)-128 regulates the proliferation and differentiation of neural progenitor cells by repressing pericentriolar material 1 (PCM1).
Title: MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex.
haploinsufficiency at the Pcm1 locus can induce a range of neuroanatomical and behavioral phenotypes that support the candidacy of this locus in neuropsychiatric disorders.
Title: Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1).
deletion of Htt in ependymal cells led to PCM1 mislocalization, alteration of the cilia layer, and hydrocephalus
Title: Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
Pcm1 colocalized with centrosomal components in cytoplasmic granules surrounding nascent centrioles. Interfering with Pcm1 reduced the amount of centrosomal proteins at basal bodies but did not prevent centriole assembly.
Title: Molecular characterization of centriole assembly in ciliated epithelial cells.
results identify a novel role for PCM- 1 in cell cycle regulation, and indicate that PCM-1 must fulfill an essential function for cells to complete interphase
Title: Arrest of cell cycle progression during first interphase in murine zygotes microinjected with anti-PCM-1 antibodies.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MGI:1278399 (e-PCR)
- UniSTS:144138

NoName (e-PCR)
- UniSTS:235878

Homology

Homologs of the Pcm1 gene: The Pcm1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 487 organisms have orthologs with human gene Pcm1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interkinetic nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport involved in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in intraciliary transport involved in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule anchoring at centrosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within microtubule anchoring at centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to centrosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex localization to centriolar satellite	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein complex stability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in centriolar satellite	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in centriolar satellite	IDA Inferred from Direct Assay more info	PubMed
is_active_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary transition zone	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: pericentriolar material 1 protein

Names: PCM-1; mPCM-1; pericentriolar material gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403817.1 → NP_001390746.1 pericentriolar material 1 protein isoform 1

Status: VALIDATED

Source sequence(s)

AC144926, AC156554
NM_001403819.1 → NP_001390748.1 pericentriolar material 1 protein isoform 2

Status: VALIDATED

Source sequence(s)

AC144926, AC156554
NM_001403820.1 → NP_001390749.1 pericentriolar material 1 protein isoform 3

Status: VALIDATED

Source sequence(s)

AC144926, AC156554
NM_001403823.1 → NP_001390752.1 pericentriolar material 1 protein isoform 5

Status: VALIDATED

Source sequence(s)

AC144926, AC156554
NM_001403824.1 → NP_001390753.1 pericentriolar material 1 protein isoform 6

Status: VALIDATED

Source sequence(s)

AC144926, AC156554
NM_001403825.1 → NP_001390754.1 pericentriolar material 1 protein isoform 7

Status: VALIDATED

Source sequence(s)

AC144926, AC156554
NM_023662.4 → NP_076151.2 pericentriolar material 1 protein isoform 4

See identical proteins and their annotated locations for NP_076151.2

Status: VALIDATED

Source sequence(s)

AC144926, AC156554

Consensus CDS

CCDS22261.1

UniProtKB/Swiss-Prot

Q9CT57, Q9R0L6

Related

ENSMUSP00000039709.8, ENSMUST00000045218.9

Conserved Domains (1) summary

pfam15717
Location:1369 → 1999

PCM1_C; Pericentriolar material 1 C terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

41692521..41787125

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153815.1 → XP_036009708.1 pericentriolar material 1 protein isoform X1

Conserved Domains (1) summary

pfam15717
Location:1415 → 2045

PCM1_C; Pericentriolar material 1 C-terminus
XM_036153818.1 → XP_036009711.1 pericentriolar material 1 protein isoform X6

Conserved Domains (1) summary

pfam15717
Location:1415 → 2000

PCM1_C; Pericentriolar material 1 C-terminus
XM_006509298.3 → XP_006509361.1 pericentriolar material 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9R0L6

Related

ENSMUSP00000147887.2, ENSMUST00000211247.2

Conserved Domains (1) summary

pfam15717
Location:1408 → 2038

PCM1_C; Pericentriolar material 1 C-terminus
XM_006509300.3 → XP_006509363.1 pericentriolar material 1 protein isoform X7

Conserved Domains (1) summary

pfam15717
Location:1408 → 1993

PCM1_C; Pericentriolar material 1 C-terminus
XM_006509301.3 → XP_006509364.1 pericentriolar material 1 protein isoform X9

Conserved Domains (2) summary

COG1196
Location:229 → 463

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15717
Location:1353 → 1983

PCM1_C; Pericentriolar material 1 C-terminus
XM_036153819.1 → XP_036009712.1 pericentriolar material 1 protein isoform X8

Conserved Domains (2) summary

COG1196
Location:229 → 463

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15717
Location:1357 → 1987

PCM1_C; Pericentriolar material 1 C-terminus
XM_006509302.3 → XP_006509365.1 pericentriolar material 1 protein isoform X10

Conserved Domains (2) summary

COG1196
Location:229 → 463

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15717
Location:1350 → 1980

PCM1_C; Pericentriolar material 1 C-terminus
XM_036153817.1 → XP_036009710.1 pericentriolar material 1 protein isoform X4

Conserved Domains (1) summary

pfam15717
Location:1376 → 2006

PCM1_C; Pericentriolar material 1 C-terminus
XM_036153822.1 → XP_036009715.1 pericentriolar material 1 protein isoform X13

Conserved Domains (1) summary

pfam15717
Location:1369 → 1954

PCM1_C; Pericentriolar material 1 C-terminus
XM_017312615.3 → XP_017168104.1 pericentriolar material 1 protein isoform X15

Conserved Domains (2) summary

TIGR02302
Location:231 → 417

aProt_lowcomp; TIGR02302 family protein

pfam15717
Location:1314 → 1944

PCM1_C; Pericentriolar material 1 C-terminus
XM_036153823.1 → XP_036009716.1 pericentriolar material 1 protein isoform X14

Conserved Domains (1) summary

pfam15717
Location:1318 → 1948

PCM1_C; Pericentriolar material 1 C-terminus
XM_036153824.1 → XP_036009717.1 pericentriolar material 1 protein isoform X16

Conserved Domains (1) summary

pfam15717
Location:1311 → 1941

PCM1_C; Pericentriolar material 1 C-terminus
XM_036153816.1 → XP_036009709.1 pericentriolar material 1 protein isoform X3

Conserved Domains (1) summary

pfam15717
Location:1382 → 2012

PCM1_C; Pericentriolar material 1 C-terminus
XM_006509299.4 → XP_006509362.1 pericentriolar material 1 protein isoform X5

Conserved Domains (1) summary

pfam15717
Location:1375 → 2005

PCM1_C; Pericentriolar material 1 C-terminus
XM_036153821.1 → XP_036009714.1 pericentriolar material 1 protein isoform X12

Conserved Domains (1) summary

pfam15717
Location:1375 → 1960

PCM1_C; Pericentriolar material 1 C-terminus
XM_036153820.1 → XP_036009713.1 pericentriolar material 1 protein isoform X11

Conserved Domains (1) summary

pfam15717
Location:1343 → 1973

PCM1_C; Pericentriolar material 1 C-terminus