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ZBTB7B zinc finger and BTB domain containing 7B [ Homo sapiens (human) ]

Gene ID: 51043, updated on 1-Jun-2020

Summary

Official Symbol
ZBTB7Bprovided by HGNC
Official Full Name
zinc finger and BTB domain containing 7Bprovided by HGNC
Primary source
HGNC:HGNC:18668
See related
Ensembl:ENSG00000160685 MIM:607646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKROX; THPOK; ZFP67; ZBTB15; ZFP-67; c-KROX; hcKROX; ZNF857B
Summary
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Broad expression in skin (RPKM 39.5), duodenum (RPKM 31.2) and 25 other tissues See more
Orthologs

Genomic context

See ZBTB7B in Genome Data Viewer
Location:
1q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155002628..155018523)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154975106..154991001)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene lens epithelial protein Neighboring gene DC-STAMP domain containing 2 Neighboring gene DC-STAMP domain containing 1 Neighboring gene DCST1 antisense RNA 1 Neighboring gene ADAM metallopeptidase domain 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686G01254

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
NK T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
adaptive thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ectoderm development TAS
Traceable Author Statement
more info
PubMed 
interleukin-17 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
lactation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of CD8-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NK T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of T-helper 17 cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of CD4-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of SREBP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of histone deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription involved in cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
response to insulin ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 7B
Names
T-helper-inducing POZ/Krueppel-like factor
krueppel-related zinc finger protein cKrox
zinc finger and BTB domain containing 15
zinc finger protein 67 homolog
zinc finger protein 857B
zinc finger protein Th-POK

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252406.3NP_001239335.1  zinc finger and BTB domain-containing protein 7B isoform 2

    See identical proteins and their annotated locations for NP_001239335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2).
    Source sequence(s)
    AI270090, AK304762, AL451085, BC012070, CV572166, DB241444
    Consensus CDS
    CCDS58030.1
    UniProtKB/Swiss-Prot
    O15156
    Related
    ENSP00000406286.2, ENST00000417934.6
    Conserved Domains (4) summary
    COG5048
    Location:379458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:410430
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:58178
    BTB; BTB/POZ domain
    pfam13465
    Location:450475
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001256455.2NP_001243384.1  zinc finger and BTB domain-containing protein 7B isoform 1

    See identical proteins and their annotated locations for NP_001243384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons in the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, comapred to variant 3. The encoded isoform (1) is shorter at the N-terminus, compared to isoform 2.
    Source sequence(s)
    AI270090, AL451085, BC012070, CV572166
    Consensus CDS
    CCDS1081.1
    UniProtKB/Swiss-Prot
    O15156
    Related
    ENSP00000438647.1, ENST00000535420.5
    Conserved Domains (4) summary
    COG5048
    Location:345424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24144
    BTB; BTB/POZ domain
    pfam13465
    Location:416441
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001377451.1NP_001364380.1  zinc finger and BTB domain-containing protein 7B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL451085
  4. NM_001377452.1NP_001364381.1  zinc finger and BTB domain-containing protein 7B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL451085
  5. NM_001377453.1NP_001364382.1  zinc finger and BTB domain-containing protein 7B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL451085
    Related
    ENSP00000357411.3, ENST00000368426.3
  6. NM_001377454.1NP_001364383.1  zinc finger and BTB domain-containing protein 7B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL451085
  7. NM_001377455.1NP_001364384.1  zinc finger and BTB domain-containing protein 7B isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL451085

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155002628..155018523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711359.2XP_006711422.1  zinc finger and BTB domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006711422.1

    UniProtKB/Swiss-Prot
    O15156
    Conserved Domains (4) summary
    COG5048
    Location:345424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24144
    BTB; BTB/POZ domain
    pfam13465
    Location:416441
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006711354.1XP_006711417.1  zinc finger and BTB domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006711417.1

    UniProtKB/Swiss-Prot
    O15156
    Conserved Domains (4) summary
    COG5048
    Location:345424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24144
    BTB; BTB/POZ domain
    pfam13465
    Location:416441
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011509598.2XP_011507900.1  zinc finger and BTB domain-containing protein 7B isoform X3

    See identical proteins and their annotated locations for XP_011507900.1

    UniProtKB/Swiss-Prot
    O15156
    Conserved Domains (4) summary
    COG5048
    Location:379458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:410430
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:58178
    BTB; BTB/POZ domain
    pfam13465
    Location:450475
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011509599.2XP_011507901.1  zinc finger and BTB domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011507901.1

    UniProtKB/Swiss-Prot
    O15156
    Conserved Domains (4) summary
    COG5048
    Location:345424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24144
    BTB; BTB/POZ domain
    pfam13465
    Location:416441
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006711357.1XP_006711420.1  zinc finger and BTB domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006711420.1

    UniProtKB/Swiss-Prot
    O15156
    Conserved Domains (4) summary
    COG5048
    Location:345424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24144
    BTB; BTB/POZ domain
    pfam13465
    Location:416441
    zf-H2C2_2; Zinc-finger double domain
  6. XM_006711358.1XP_006711421.1  zinc finger and BTB domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006711421.1

    UniProtKB/Swiss-Prot
    O15156
    Conserved Domains (4) summary
    COG5048
    Location:345424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24144
    BTB; BTB/POZ domain
    pfam13465
    Location:416441
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017001399.1XP_016856888.1  zinc finger and BTB domain-containing protein 7B isoform X2

  8. XM_006711356.3XP_006711419.1  zinc finger and BTB domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006711419.1

    UniProtKB/Swiss-Prot
    O15156
    Conserved Domains (4) summary
    COG5048
    Location:345424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:376396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24144
    BTB; BTB/POZ domain
    pfam13465
    Location:416441
    zf-H2C2_2; Zinc-finger double domain
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