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Zbtb7b zinc finger and BTB domain containing 7B [ Mus musculus (house mouse) ]

Gene ID: 22724, updated on 17-Jan-2023

Summary

Official Symbol
Zbtb7bprovided by MGI
Official Full Name
zinc finger and BTB domain containing 7Bprovided by MGI
Primary source
MGI:MGI:102755
See related
Ensembl:ENSMUSG00000028042 AllianceGenome:MGI:102755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thpok; Zfp67; c-Krox
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of alpha-beta T cell activation. Acts upstream of or within regulation of alpha-beta T cell differentiation and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; sensory organ; and skin. Orthologous to human ZBTB7B (zinc finger and BTB domain containing 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 66.4), duodenum adult (RPKM 59.2) and 18 other tissues See more
Orthologs
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Genomic context

See Zbtb7b in Genome Data Viewer
Location:
3 F1; 3 39.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89284951..89300980, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89377644..89393673, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 15 (metargidin) Neighboring gene DC-STAMP domain containing 1 Neighboring gene DC-STAMP domain containing 2 Neighboring gene predicted gene 15417 Neighboring gene lens epithelial protein Neighboring gene flavin adenine dinucleotide synthetase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (17)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC102577

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in NK T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adaptive thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NK T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of SREBP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of T-helper cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 7B
Names
T-helper-inducing POZ/Krueppel-like factor
Vzinc finger and BTB domain containing 7B
krueppel-related zinc finger protein cKrox
zinc finger protein 67
zinc finger protein Th-POK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355206.2NP_001342135.2  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
  2. NM_001355211.2NP_001342140.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS17504.1
    UniProtKB/Swiss-Prot
    Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
    Related
    ENSMUSP00000103055.2, ENSMUST00000107432.8
    Conserved Domains (4) summary
    COG5048
    Location:349428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420445
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001355212.2NP_001342141.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS17504.1
    UniProtKB/Swiss-Prot
    Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
    Related
    ENSMUSP00000103056.2, ENSMUST00000107433.8
    Conserved Domains (4) summary
    COG5048
    Location:349428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420445
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001410678.1NP_001397607.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
  5. NM_001410679.1NP_001397608.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
  6. NM_001410680.1NP_001397609.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
  7. NM_001410681.1NP_001397610.1  zinc finger and BTB domain-containing protein 7B

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/Swiss-Prot
    Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
  8. NM_009565.6NP_033591.2  zinc finger and BTB domain-containing protein 7B

    See identical proteins and their annotated locations for NP_033591.2

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS17504.1
    UniProtKB/Swiss-Prot
    Q64321, Q80VV5
    UniProtKB/TrEMBL
    Q5BJ24
    Related
    ENSMUSP00000029677.9, ENSMUST00000029677.9
    Conserved Domains (4) summary
    COG5048
    Location:349428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420445
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89284951..89300980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252554.2XP_030108414.1  zinc finger and BTB domain-containing protein 7B isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:349428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420445
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006501314.3XP_006501377.1  zinc finger and BTB domain-containing protein 7B isoform X1

    UniProtKB/Swiss-Prot
    Q64321
    UniProtKB/TrEMBL
    Q5BJ24
    Conserved Domains (4) summary
    COG5048
    Location:349428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420445
    zf-H2C2_2; Zinc-finger double domain
  3. XM_006501313.3XP_006501376.1  zinc finger and BTB domain-containing protein 7B isoform X1

    UniProtKB/Swiss-Prot
    Q64321
    UniProtKB/TrEMBL
    Q5BJ24
    Conserved Domains (4) summary
    COG5048
    Location:349428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420445
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006501316.4XP_006501379.1  zinc finger and BTB domain-containing protein 7B isoform X1

    UniProtKB/Swiss-Prot
    Q64321
    UniProtKB/TrEMBL
    Q5BJ24
    Conserved Domains (4) summary
    COG5048
    Location:349428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18327
    Location:9142
    BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
    pfam13465
    Location:420445
    zf-H2C2_2; Zinc-finger double domain