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PLA2G3 phospholipase A2 group III [ Homo sapiens (human) ]

Gene ID: 50487, updated on 11-Jun-2021

Summary

Official Symbol
PLA2G3provided by HGNC
Official Full Name
phospholipase A2 group IIIprovided by HGNC
Primary source
HGNC:HGNC:17934
See related
Ensembl:ENSG00000100078 MIM:611651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPLA2III; sPLA2-III; GIII-SPLA2
Summary
This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]
Expression
Biased expression in skin (RPKM 3.5), esophagus (RPKM 1.9) and 4 other tissues See more
Orthologs
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Genomic context

See PLA2G3 in Genome Data Viewer
Location:
22q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (31134807..31140508, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31530793..31536494, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372995 Neighboring gene selenoprotein M Neighboring gene inositol polyphosphate-5-phosphatase J Neighboring gene ribosomal protein S15a pseudogene 37 Neighboring gene small nuclear ribonucleoprotein-associated protein N pseudogene Neighboring gene microRNA 3928

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed
env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in acrosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in high-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoxygenase pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage activation IEA
Inferred from Electronic Annotation
more info
 
involved_in mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phosphatidylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylinositol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylserine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of histamine secretion by mast cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage derived foam cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mast cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of prostaglandin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in production of molecular mediator involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm axoneme assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
group 3 secretory phospholipase A2
Names
group III secreted phospholipase A2
phosphatidylcholine 2-acylhydrolase 3
phosphatidylcholine 2-acylhydrolase GIII
NP_056530.2
XP_011528506.1
XP_011528507.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015715.5NP_056530.2  group 3 secretory phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_056530.2

    Status: REVIEWED

    Source sequence(s)
    AC005005, AF220490, BC025316
    Consensus CDS
    CCDS13889.1
    UniProtKB/Swiss-Prot
    Q9NZ20
    Related
    ENSP00000215885.3, ENST00000215885.4
    Conserved Domains (2) summary
    cd04704
    Location:151247
    PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...
    cd04705
    Location:314427
    PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    31134807..31140508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530205.1XP_011528507.1  group 3 secretory phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_011528507.1

    Conserved Domains (2) summary
    cd04705
    Location:133246
    PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...
    cl05417
    Location:3566
    PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. XM_011530204.1XP_011528506.1  group 3 secretory phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_011528506.1

    Conserved Domains (2) summary
    cd04705
    Location:133246
    PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...
    cl05417
    Location:3566
    PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RNA

  1. XR_937865.2 RNA Sequence

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