Conserved Protein Domain Family
PLA2_group_III_like

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cd04705: PLA2_group_III_like 
PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids; secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers.
Statistics
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PSSM-Id: 153094
View PSSM: cd04705
Aligned: 9 rows
Threshold Bit Score: 96.4403
Threshold Setting Gi: 47227807
Created: 5-Jan-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
 
Feature 1:putative catalytic residues [active site]
Evidence:

cd04705 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd04705 is a member of the superfamily cl05417.
cd00125:PLA2ccd00618:PLA2_likecd04704:PLA2_bee_venom_likecd04705:PLA2_group_III_likecd04706:PLA2_plantcd04707:otoconin_907657126263292571199115981091137621195715117396701271043908263379094722780776571262632925711991159810911376211957151173967012710439082633790947227807
cd04705 Sequence Cluster
cd04705 Sequence Cluster
Sub-family Hierarchy
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 cd04705 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             #          
gi 7657126   314 HQKGSKRPSKANTta----------------lqDPMVSprldvaptglqgpqgglkPQGARWVCRSFRRHLdqCEHQIGP 377
gi 119911598   5 TTLRIERWTKEKTedd---------------tsSWDESr----------------vRGEFKNTDRCCWKHK--CAGHIVR 51
gi 109113762   5 TTLTIERWTKEKTepk---------------vrSWDESr----------------cCGDCKEPDKCCWKHKq-CTGHIIY 52
gi 119571511   7 NRLPSWERGHLLAgv----------------asSTDVStf---------------sEGDCKEPDKCCWRHKq-CTGHIIY 54
gi 71043908   30 TRLPSWKRGYPASve-----------------sSSDMSsf---------------sEGENKETERCCWKHQq-CPVHIIH 76
gi 26337909    1 MSWTAEGRLLYKVgiyell--------hsiqapAPLCSls--------------lhAGVFHGPDLCCREHDq-CPQTISP 57
gi 73967012    7 NRLPSWERGHLLAgv----------------asSTDAStf--------------ssEGEFKDPDRCCWKHKq-CTGHIIH 55
gi 26329257  295 PSKHPQKRGPQQTqarrhstttttpfqtpaissRPDMIprgqpgvph-lgfqdgpkHQSAHRVCRSLRHLDq-CEHQIKP 372
gi 47227807   13 DRGTIFRAGLSSPvcigg-----------agapRDLVKadvln--------ravdaEKENKETFSLLNGIF--CAKMLTD 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       #                                
gi 7657126   378 reiefq---------------------------llnsaQEPLFHCNCTRRLARFLRLHsppe---vtnmLWELLGTTCFK 427
gi 119911598  52 pfspdc--------------------------vhhdvhLHSLSHCDCDSRLKDCSEKTnsssg-dvgptCSRDVDSTCFD 104
gi 109113762  53 pfasdc--------------------------vchslhLRSVNHCNCNSRLKDCSEDSsssrg--tgptCSHVIESPCFE 104
gi 119571511  55 pfasdc--------------------------vrhslhLHSVNHCNCNSRLKDSSEDSsssrg--agptCSHVIESPCFE 106
gi 71043908   77 sfsdcg---------------------------hhnrcMHAVSHCNCESRCQSYRPISvaif----hhpTHHMYMTDDLN 125
gi 26337909   58 lqynyg---------------------------irnfrFHTISHCDCDARCRAYGSTP-----------LAHLRPRTYYN 99
gi 73967012   56 pftsdy--------------------------ghhnlhLHSVSHCDCDSRLKDCSEKTnssssrdvgpaCSRDEGSTCFN 109
gi 26329257  373 qetkfh---------------------------llnsaQMPLFHCDCTRRLARFLRLHsppa---gtdkVWDLLGTTCFK 422
gi 47227807   72 ggnflyqvsdgveivesvvspsgavvncsvlfgytnfkWHSISHCDCDEKLKACLRRVnd--------tSSRVVGQAFFN 143

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