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OPRK1 opioid receptor kappa 1 [ Homo sapiens (human) ]

Gene ID: 4986, updated on 28-Jun-2020

Summary

Official Symbol
OPRK1provided by HGNC
Official Full Name
opioid receptor kappa 1provided by HGNC
Primary source
HGNC:HGNC:8154
See related
Ensembl:ENSG00000082556 MIM:165196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1
Summary
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression
Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues See more
Orthologs

Genomic context

See OPRK1 in Genome Data Viewer
Location:
8q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (53225716..53251697, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54138276..54164257, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase RING2-like Neighboring gene uncharacterized LOC105375836 Neighboring gene EI24 pseudogene 5 Neighboring gene DNA polymerase epsilon 2, accessory subunit pseudogene Neighboring gene uncharacterized LOC100507516

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Kappa-opioid receptor (KOR) agonist treatment of CD4(+) lymphocytes inhibits HIV-1 envelope gp120/41-mediated membrane fusion via downregulation of CXCR4 PubMed
Tat tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynorphin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynorphin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
dynorphin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
opioid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-inhibiting opioid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
immune response IDA
Inferred from Direct Assay
more info
PubMed 
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
opioid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of saliva secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
sensory perception TAS
Traceable Author Statement
more info
PubMed 
sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kappa-type opioid receptor
Names
Opiate receptor, kappa-1
kappa opioid receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000912.5NP_000903.2  kappa-type opioid receptor isoform 1

    See identical proteins and their annotated locations for NP_000903.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt . This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    AK023198, AY466378, BC099912, DA264471, U17298
    Consensus CDS
    CCDS6152.1
    UniProtKB/Swiss-Prot
    P41145
    Related
    ENSP00000265572.3, ENST00000265572.8
    Conserved Domains (1) summary
    cd15091
    Location:60341
    7tmA_Kappa_opioid_R; opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001282904.1NP_001269833.1  kappa-type opioid receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon in the mid-region, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC009646, AK310407, BF061371
    Consensus CDS
    CCDS64895.1
    UniProtKB/Swiss-Prot
    P41145
    Related
    ENSP00000483000.1, ENST00000612786.4
    Conserved Domains (1) summary
    pfam00001
    Location:1241
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001318497.2NP_001305426.1  kappa-type opioid receptor isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AK023198, AY466378, BC099912, DA264471, U17298
    UniProtKB/Swiss-Prot
    P41145
    Related
    ENSP00000500765.2, ENST00000673285.2
    Conserved Domains (2) summary
    pfam00001
    Location:76330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:71271
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    53225716..53251697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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