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OPRK1 opioid receptor kappa 1 [ Homo sapiens (human) ]

Gene ID: 4986, updated on 2-Nov-2024

Summary

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Official Symbol
OPRK1provided by HGNC
Official Full Name
opioid receptor kappa 1provided by HGNC
Primary source
HGNC:HGNC:8154
See related
Ensembl:ENSG00000082556 MIM:165196; AllianceGenome:HGNC:8154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1
Summary
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression
Biased expression in brain (RPKM 1.8), prostate (RPKM 1.6) and 3 other tissues See more
Orthologs
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Genomic context

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See OPRK1 in Genome Data Viewer
Location:
8q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (53225724..53251637, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (53602209..53628122, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54138284..54164197, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase RING2-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53930926-53931660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:53931661-53932394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27350 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:54055436-54056635 Neighboring gene uncharacterized LOC105375836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27354 Neighboring gene EI24 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27356 Neighboring gene uncharacterized LOC124901946 Neighboring gene DNA polymerase epsilon 2, accessory subunit pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor. Ma J, et al. Cell Death Dis, 2014 Mar 6. PMID 24603327, Free PMC Article
  2. Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. Chavkin C, et al. J Pharmacol Exp Ther, 2004 Mar. PMID 14718611
  3. Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse. Lutz PE, et al. Biol Psychiatry, 2018 Nov 15. PMID 28886759
  4. Down-regulation of the tumour suppressor κ-opioid receptor predicts poor prognosis in hepatocellular carcinoma patients. Chen D, et al. BMC Cancer, 2017 Aug 18. PMID 28821282, Free PMC Article
  5. Association of OPRK1 gene polymorphisms with opioid dependence in addicted men undergoing methadone treatment in an Iranian population. Albonaim A, et al. J Addict Dis, 2017 Oct-Dec. PMID 28786760

See all (132) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. kappa-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-kappaB pathway.
    Title: κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway.
  2. Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms.
    Title: Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms.
  3. Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone.
    Title: Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone.
  4. The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma.
    Title: The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma.
  5. Opioids in cancer: The kappaopioid receptor (Review).
    Title: Opioids in cancer: The κ‑opioid receptor (Review).
  6. Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population.
    Title: Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population.
  7. Activation of kappa-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells.
    Title: Activation of κ-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells.
  8. Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers.
    Title: Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers.
  9. Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.
    Title: Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.
  10. Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving.
    Title: Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving.
Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Kappa-opioid receptor (KOR) agonist treatment of CD4(+) lymphocytes inhibits HIV-1 envelope gp120/41-mediated membrane fusion via downregulation of CXCR4 PubMed
Tat tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled opioid receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dynorphin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynorphin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dynorphin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor serine/threonine kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled opioid receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in conditioned place preference IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in eating behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in estrous cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maternal behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of luteinizing hormone secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of eating behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of saliva secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to acrylamide IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estrogen IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nicotine IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception TAS
Traceable Author Statement
more info
 PubMed 
involved_in sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sensory perception of temperature stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
  
located_in axon terminus IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kappa-type opioid receptor
Names
Opiate receptor, kappa-1
kappa opioid receptor

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000912.5 → NP_000903.2  kappa-type opioid receptor isoform 1

    See identical proteins and their annotated locations for NP_000903.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt . This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    AK023198, AY466378, BC099912, DA264471, U17298
    Consensus CDS
    CCDS6152.1
    UniProtKB/Swiss-Prot
    E5RHC9, P41145, Q499G4
    UniProtKB/TrEMBL
    B2R7P1
    Related
    ENSP00000265572.3, ENST00000265572.8
    Conserved Domains (1) summary
    cd15091
    Location:60 → 341
    7tmA_Kappa_opioid_R; opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001282904.2 → NP_001269833.1  kappa-type opioid receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon in the mid-region, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC009646, AK310407, BF061371
    Consensus CDS
    CCDS64895.1
    UniProtKB/Swiss-Prot
    P41145
    Related
    ENSP00000430923.1, ENST00000524278.5
    Conserved Domains (1) summary
    pfam00001
    Location:1 → 241
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_001318497.2 → NP_001305426.1  kappa-type opioid receptor isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AK023198, AY466378, BC099912, DA264471, U17298
    Consensus CDS
    CCDS94292.1
    UniProtKB/TrEMBL
    A0A5F9ZI09, B2R7P1
    Related
    ENSP00000500765.2, ENST00000673285.2
    Conserved Domains (2) summary
    pfam00001
    Location:76 → 330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:71 → 271
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    53225724..53251637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    53602209..53628122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41145.2 GenPept UniProtKB/Swiss-Prot:P41145

Gene LinkOut

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