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OGG1 8-oxoguanine DNA glycosylase [ Homo sapiens (human) ]

Gene ID: 4968, updated on 9-Sep-2018

Summary

Official Symbol
OGG1provided by HGNC
Official Full Name
8-oxoguanine DNA glycosylaseprovided by HGNC
Primary source
HGNC:HGNC:8125
See related
Ensembl:ENSG00000114026 MIM:601982; Vega:OTTHUMG00000097091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMMH; MUTM; OGH1; HOGG1
Summary
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in kidney (RPKM 5.9), lymph node (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See OGG1 in Genome Data Viewer
Location:
3p25.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (9749944..9788246)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9791628..9829468)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene copine family member 9 Neighboring gene bromodomain and PHD finger containing 1 Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene transcriptional adaptor 3 Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat appears to upregulate OGG1 expression by sequestrating AP-4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
endonuclease activity TAS
Traceable Author Statement
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
oxidized purine DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidized purine DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
oxidized purine nucleobase lesion DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidized purine nucleobase lesion DNA N-glycosylase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
base-excision repair TAS
Traceable Author Statement
more info
PubMed 
base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
depurination TAS
Traceable Author Statement
more info
 
depyrimidination TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of double-strand break repair via single-strand annealing IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-excision repair, DNA incision IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to folic acid IEA
Inferred from Electronic Annotation
more info
 
response to light stimulus IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
response to radiation IDA
Inferred from Direct Assay
more info
PubMed 
telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N-glycosylase/DNA lyase
Names
8-hydroxyguanine DNA glycosylase
AP lyase
DNA-apurinic or apyrimidinic site lyase
OGG1 type 1f
NP_001341577.1
NP_001341578.1
NP_001341579.1
NP_001341580.1
NP_001341581.1
NP_002533.1
NP_058212.1
NP_058213.1
NP_058214.1
NP_058434.1
NP_058436.1
NP_058437.1
NP_058438.1
XP_011532062.1
XP_016861982.1
XP_016861983.1
XP_016861984.1
XP_016861985.1
XP_016861986.1
XP_016861988.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012106.1 RefSeqGene

    Range
    5001..21726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001354648.1NP_001341577.1  N-glycosylase/DNA lyase isoform 1d

    Status: REVIEWED

    Source sequence(s)
    AC022382
    Conserved Domains (1) summary
    TIGR00588
    Location:11189
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
  2. NM_001354649.1NP_001341578.1  N-glycosylase/DNA lyase isoform 1e

    Status: REVIEWED

    Source sequence(s)
    AC022382
    Conserved Domains (1) summary
    TIGR00588
    Location:11217
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
  3. NM_001354650.1NP_001341579.1  N-glycosylase/DNA lyase isoform 2f

    Status: REVIEWED

    Source sequence(s)
    AC022382
    Conserved Domains (1) summary
    TIGR00588
    Location:11249
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
  4. NM_001354651.1NP_001341580.1  N-glycosylase/DNA lyase isoform 2g

    Status: REVIEWED

    Source sequence(s)
    AC022382
    Conserved Domains (1) summary
    TIGR00588
    Location:11300
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
  5. NM_001354652.1NP_001341581.1  N-glycosylase/DNA lyase isoform 2h

    Status: REVIEWED

    Source sequence(s)
    AC022382
    Conserved Domains (1) summary
    TIGR00588
    Location:11249
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
  6. NM_002542.5NP_002533.1  N-glycosylase/DNA lyase isoform 1a

    See identical proteins and their annotated locations for NP_002533.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 1a represents the predominant form of this gene.
    Source sequence(s)
    BM847736, U88527, Y11838
    Consensus CDS
    CCDS2581.1
    UniProtKB/Swiss-Prot
    O15527
    UniProtKB/TrEMBL
    E5KPN1
    Related
    ENSP00000342851.7, OTTHUMP00000122619, ENST00000344629.11, OTTHUMT00000214223
    Conserved Domains (3) summary
    TIGR00588
    Location:11328
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139319
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
  7. NM_016819.3NP_058212.1  N-glycosylase/DNA lyase isoform 1b

    See identical proteins and their annotated locations for NP_058212.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 1b contains a 244 bp insertion between exons 6 and 7, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019532, AC022382, BM847736, U88527, Y11838
    Consensus CDS
    CCDS43046.1
    UniProtKB/Swiss-Prot
    O15527
    Related
    ENSP00000345520.5, OTTHUMP00000207398, ENST00000339511.9, OTTHUMT00000338738
    Conserved Domains (3) summary
    TIGR00588
    Location:11317
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139316
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
  8. NM_016820.3NP_058213.1  N-glycosylase/DNA lyase isoform 1c

    See identical proteins and their annotated locations for NP_058213.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 1c contains a 17 bp insertion before exon 7, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019532, BM847736, U88527, U96710, Y11838
    Consensus CDS
    CCDS2580.1
    UniProtKB/Swiss-Prot
    O15527
    UniProtKB/TrEMBL
    E5KPN0
    Related
    ENSP00000305584.7, OTTHUMP00000122620, ENST00000302003.11, OTTHUMT00000214224
    Conserved Domains (3) summary
    TIGR00588
    Location:11316
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139316
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
  9. NM_016821.2NP_058214.1  N-glycosylase/DNA lyase isoform 2a

    See identical proteins and their annotated locations for NP_058214.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2a contains an alternate exon 8 instead of exon 7, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AW614399, BM847736, U88620
    Consensus CDS
    CCDS2576.1
    UniProtKB/Swiss-Prot
    O15527
    UniProtKB/TrEMBL
    E5KPM5
    Related
    ENSP00000306561.7, OTTHUMP00000122618, ENST00000302036.11, OTTHUMT00000214222
    Conserved Domains (3) summary
    TIGR00588
    Location:11322
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139319
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
  10. NM_016826.2NP_058434.1  N-glycosylase/DNA lyase isoform 2b

    See identical proteins and their annotated locations for NP_058434.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2b contains an alternate exon 8 and skips exons 5 and 6, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019528, AW614399, BM847736, U88527
    Consensus CDS
    CCDS2577.1
    UniProtKB/Swiss-Prot
    O15527
    UniProtKB/TrEMBL
    E5KPM6
    Related
    ENSP00000303132.6, ENST00000349503.9
    Conserved Domains (2) summary
    cd00056
    Location:139273
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
  11. NM_016827.2NP_058436.1  N-glycosylase/DNA lyase isoform 2c

    See identical proteins and their annotated locations for NP_058436.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2c contains an alternate exon 8 and skips exons 4 to 6, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019529, AW614399, BM847736, U88527
    Consensus CDS
    CCDS2578.1
    UniProtKB/Swiss-Prot
    O15527
    UniProtKB/TrEMBL
    E5KPM8
    Related
    ENSP00000373337.5, OTTHUMP00000122622, ENST00000383826.9, OTTHUMT00000214226
    Conserved Domains (2) summary
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
    cl23768
    Location:139168
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
  12. NM_016828.2NP_058437.1  N-glycosylase/DNA lyase isoform 2d

    See identical proteins and their annotated locations for NP_058437.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2d contains an alternate exon 8 and a 100 bp insertion, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019530, AW614399, BM847736, U88527
    Consensus CDS
    CCDS2579.1
    UniProtKB/Swiss-Prot
    O15527
    UniProtKB/TrEMBL
    E5KPM7
    Related
    ENSP00000305527.8, OTTHUMP00000122623, ENST00000302008.12, OTTHUMT00000214227
    Conserved Domains (3) summary
    TIGR00588
    Location:11316
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139317
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
  13. NM_016829.2NP_058438.1  N-glycosylase/DNA lyase isoform 2e

    See identical proteins and their annotated locations for NP_058438.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2e contains an alternate exon 8 and a 53 bp insertion between exons 6 and 8, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019531, AW614399, BM847736, U88527
    Consensus CDS
    CCDS46742.1
    UniProtKB/Swiss-Prot
    O15527
    UniProtKB/TrEMBL
    E5KPM9
    Related
    ENSP00000403598.2, OTTHUMP00000207399, ENST00000449570.6, OTTHUMT00000338739
    Conserved Domains (1) summary
    TIGR00588
    Location:11316
    ogg; 8-oxoguanine DNA-glycosylase (ogg)

RNA

  1. NR_148930.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022382
  2. NR_148931.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022382
  3. NR_148932.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022382

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    9749944..9788246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533760.2XP_011532062.1  N-glycosylase/DNA lyase isoform X4

    Conserved Domains (3) summary
    TIGR00588
    Location:11317
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139319
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
  2. XM_017006499.2XP_016861988.1  N-glycosylase/DNA lyase isoform X6

  3. XM_017006496.2XP_016861985.1  N-glycosylase/DNA lyase isoform X4

    Conserved Domains (3) summary
    TIGR00588
    Location:11317
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139319
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
  4. XM_017006497.2XP_016861986.1  N-glycosylase/DNA lyase isoform X5

  5. XM_017006494.2XP_016861983.1  N-glycosylase/DNA lyase isoform X2

  6. XM_017006495.2XP_016861984.1  N-glycosylase/DNA lyase isoform X3

  7. XM_017006493.2XP_016861982.1  N-glycosylase/DNA lyase isoform X1

    Conserved Domains (2) summary
    cd00056
    Location:139250
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

RNA

  1. XR_001740156.2 RNA Sequence

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