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Ogg1 8-oxoguanine DNA-glycosylase 1 [ Mus musculus (house mouse) ]

Gene ID: 18294, updated on 11-Apr-2024

Summary

Official Symbol
Ogg1provided by MGI
Official Full Name
8-oxoguanine DNA-glycosylase 1provided by MGI
Primary source
MGI:MGI:1097693
See related
Ensembl:ENSMUSG00000030271 AllianceGenome:MGI:1097693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mmh
Summary
Enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity and microtubule binding activity. Acts upstream of or within base-excision repair. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 11.9), ovary adult (RPKM 9.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ogg1 in Genome Data Viewer
Location:
6 E3; 6 52.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113303959..113311149)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113326972..113334877)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene copine family member IX Neighboring gene STARR-seq mESC enhancer starr_17036 Neighboring gene STARR-positive B cell enhancer ABC_E237 Neighboring gene bromodomain and PHD finger containing, 1 Neighboring gene STARR-positive B cell enhancer ABC_E1326 Neighboring gene calcium/calmodulin-dependent protein kinase I Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA N-glycosylase activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidized base lesion DNA N-glycosylase activity TAS
Traceable Author Statement
more info
PubMed 
enables oxidized purine DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidized purine nucleobase lesion DNA N-glycosylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxidized purine nucleobase lesion DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within DNA repair IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within base-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of double-strand break repair via single-strand annealing ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of gene expression via chromosomal CpG island demethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
N-glycosylase/DNA lyase
NP_001397059.1
NP_001397060.1
NP_001397061.1
NP_035087.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410130.1NP_001397059.1  N-glycosylase/DNA lyase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC155287
  2. NM_001410131.1NP_001397060.1  N-glycosylase/DNA lyase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC155287
  3. NM_001410132.1NP_001397061.1  N-glycosylase/DNA lyase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC155287
  4. NM_010957.5NP_035087.3  N-glycosylase/DNA lyase isoform 1

    See identical proteins and their annotated locations for NP_035087.3

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Consensus CDS
    CCDS20414.1
    UniProtKB/Swiss-Prot
    O08733, O08760, O08910, O08991, O35617, O35915, Q9QXE8
    UniProtKB/TrEMBL
    Q3UIL3
    Related
    ENSMUSP00000032406.9, ENSMUST00000032406.15
    Conserved Domains (3) summary
    TIGR00588
    Location:11328
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139319
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

RNA

  1. NR_149720.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Related
    ENSMUST00000136263.4
  2. NR_176953.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Related
    ENSMUST00000204834.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113303959..113311149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)