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NUMA1 nuclear mitotic apparatus protein 1 [ Homo sapiens (human) ]

Gene ID: 4926, updated on 9-Jul-2017
Official Symbol
NUMA1provided by HGNC
Official Full Name
nuclear mitotic apparatus protein 1provided by HGNC
Primary source
HGNC:HGNC:8059
See related
Ensembl:ENSG00000137497 MIM:164009; Vega:OTTHUMG00000167697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUMA; NMP-22
Summary
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Orthologs
Location:
11q13.4
Exon count:
38
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (72002864..72080693, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71713910..71791732, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 2-like Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene ring finger protein 121 Neighboring gene uncharacterized LOC100128494 Neighboring gene interleukin 18 binding protein Neighboring gene microRNA 3165 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene anaphase promoting complex subunit 15

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with NUMA1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear mitotic apparatus protein 1 (NUMA1) at amino acid residues 2054-2055 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
disordered domain specific binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule minus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anastral spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
astral microtubule organization IDA
Inferred from Direct Assay
more info
PubMed 
astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
establishment of mitotic spindle orientation IDA
Inferred from Direct Assay
more info
PubMed 
establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of mitotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
 
lung epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus organization TAS
Traceable Author Statement
more info
PubMed 
positive regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chromosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hair follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of intracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to spindle pole body IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic spindle organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex region IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cortical microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic microtubule bundle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule bundle IDA
Inferred from Direct Assay
more info
PubMed 
microtubule minus-end IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle astral microtubule IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle pole IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle TAS
Traceable Author Statement
more info
PubMed 
spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nuclear mitotic apparatus protein 1
Names
SP-H antigen
centrophilin stabilizes mitotic spindle in mitotic cells
nuclear matrix protein-22
structural nuclear protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286561.1NP_001273490.1  nuclear mitotic apparatus protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001273490.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB210007, BC004165, BG754891, BG771637, Z11583, Z11584
    Consensus CDS
    CCDS66156.1
    UniProtKB/Swiss-Prot
    Q14980
    UniProtKB/TrEMBL
    A0A024R5M9, Q4LE64
    Related
    ENSP00000351851.6, OTTHUMP00000236522, ENST00000358965.10, OTTHUMT00000395695
    Conserved Domains (2) summary
    TIGR02168
    Location:10151717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  2. NM_006185.3NP_006176.2  nuclear mitotic apparatus protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006176.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB210007, BC004165, BC027493, BG754891, BG771637
    Consensus CDS
    CCDS31633.1
    UniProtKB/Swiss-Prot
    Q14980
    UniProtKB/TrEMBL
    Q3SYK8, Q4LE64
    Related
    ENSP00000377298.3, OTTHUMP00000236571, ENST00000393695.7, OTTHUMT00000395769
    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail

RNA

  1. NR_104476.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' terminal exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the reading frame found in variant 1.
    Source sequence(s)
    BC004165, BC103765, BG754891
    Related
    ENST00000351960.10, OTTHUMT00000395768

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

    Range
    72002864..72080693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545055.1XP_011543357.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543357.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  2. XM_011545056.2XP_011543358.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543358.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  3. XM_011545057.2XP_011543359.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543359.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  4. XM_011545060.2XP_011543362.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543362.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  5. XM_011545059.2XP_011543361.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543361.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  6. XM_011545058.1XP_011543360.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543360.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  7. XM_011545062.2XP_011543364.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543364.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  8. XM_011545066.1XP_011543368.1  nuclear mitotic apparatus protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011543368.1

    UniProtKB/TrEMBL
    A0A024R5M9
    Related
    ENSP00000478624.1, ENST00000620566.4
    Conserved Domains (2) summary
    TIGR02168
    Location:10151717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  9. XM_011545065.1XP_011543367.1  nuclear mitotic apparatus protein 1 isoform X2

    Conserved Domains (2) summary
    TIGR02168
    Location:10151717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  10. XM_006718564.1XP_006718627.1  nuclear mitotic apparatus protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006718627.1

    UniProtKB/Swiss-Prot
    Q14980
    UniProtKB/TrEMBL
    Q4LE64
    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  11. XM_011545054.1XP_011543356.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543356.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  12. XM_011545064.1XP_011543366.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543366.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  13. XM_011545061.2XP_011543363.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543363.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  14. XM_011545063.2XP_011543365.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543365.1

    Conserved Domains (2) summary
    TIGR02168
    Location:10151731
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  15. XM_017017830.1XP_016873319.1  nuclear mitotic apparatus protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A024R5M9
    Conserved Domains (2) summary
    TIGR02168
    Location:10151717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail
  16. XM_017017831.1XP_016873320.1  nuclear mitotic apparatus protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A024R5M9
    Conserved Domains (2) summary
    TIGR02168
    Location:10151717
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:2541329
    Myosin_tail_1; Myosin tail

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    71597789..71675562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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