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Numa1 nuclear mitotic apparatus protein 1 [ Mus musculus (house mouse) ]

Gene ID: 101706, updated on 18-Sep-2024

Summary

Official Symbol
Numa1provided by MGI
Official Full Name
nuclear mitotic apparatus protein 1provided by MGI
Primary source
MGI:MGI:2443665
See related
Ensembl:ENSMUSG00000066306 AllianceGenome:MGI:2443665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NuMA; 6720401E04Rik
Summary
Predicted to enable several functions, including disordered domain specific binding activity; dynein complex binding activity; and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of BMP signaling pathway; and positive regulation of keratinocyte differentiation. Acts upstream of or within lung epithelial cell differentiation. Located in several cellular components, including lateral cell cortex; mitotic spindle pole; and nuclear matrix. Is expressed in lung epithelium; midbrain ventricular layer; olfactory lobe; pigmented retinal epithelium; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 20.3), ovary adult (RPKM 17.4) and 28 other tissues See more
Orthologs
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Genomic context

See Numa1 in Genome Data Viewer
Location:
7 E2; 7 54.7 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101583169..101664166)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101933977..102014959)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1089 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene transmembrane O-methyltransferase Neighboring gene leucine rich repeat containing 51 Neighboring gene STARR-positive B cell enhancer ABC_E554 Neighboring gene STARR-positive B cell enhancer ABC_E8193 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061 Neighboring gene interleukin 18 binding protein Neighboring gene ring finger protein 121 Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule minus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule minus-end binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule plus-end binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in anastral spindle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in anastral spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in astral microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in astral microtubule organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of chromosome separation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intracellular transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mitotic spindle elongation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic spindle elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein localization to spindle pole body ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to spindle pole body ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of metaphase plate congression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex region ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cortical microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in cortical microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic microtubule bundle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic microtubule bundle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in lateral cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule bundle ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule bundle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microtubule minus-end ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule minus-end ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule plus-end ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle astral microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle astral microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitotic spindle midzone ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle midzone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in spindle microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nuclear mitotic apparatus protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403544.1NP_001390473.1  nuclear mitotic apparatus protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC167240
  2. NM_001403545.1NP_001390474.1  nuclear mitotic apparatus protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC167240
  3. NM_001403546.1NP_001390475.1  nuclear mitotic apparatus protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC167240
  4. NM_001403547.1NP_001390476.1  nuclear mitotic apparatus protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC167240
  5. NM_001403548.1NP_001390477.1  nuclear mitotic apparatus protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC167240
  6. NM_001403549.1NP_001390478.1  nuclear mitotic apparatus protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC167240
  7. NM_001403550.1NP_001390479.1  nuclear mitotic apparatus protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC167240
  8. NM_001403551.1NP_001390480.1  nuclear mitotic apparatus protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    E9Q7G0, Q80Y35
  9. NM_001403552.1NP_001390481.1  nuclear mitotic apparatus protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC167240
  10. NM_001403553.1NP_001390482.1  nuclear mitotic apparatus protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC167240
  11. NM_133947.4NP_598708.3  nuclear mitotic apparatus protein 1 isoform b

    See identical proteins and their annotated locations for NP_598708.3

    Status: VALIDATED

    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS40046.1
    UniProtKB/Swiss-Prot
    E9Q7G0, Q80Y35
    Related
    ENSMUSP00000081912.6, ENSMUST00000084852.13
    Conserved Domains (4) summary
    COG1196
    Location:11171713
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5541323
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22224
    Location:6151
    HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
    cd22298
    Location:18521910
    NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101583169..101664166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507177.4XP_006507240.1  nuclear mitotic apparatus protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006507240.1

    UniProtKB/Swiss-Prot
    E9Q7G0, Q80Y35
    Conserved Domains (4) summary
    COG1196
    Location:11171713
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5541323
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22224
    Location:6151
    HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
    cd22298
    Location:18521910
    NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
  2. XM_036152542.1XP_036008435.1  nuclear mitotic apparatus protein 1 isoform X2

    UniProtKB/Swiss-Prot
    E9Q7G0, Q80Y35
    Conserved Domains (4) summary
    COG1196
    Location:11171713
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5541323
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22224
    Location:6151
    HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
    cd22298
    Location:18521910
    NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
  3. XM_036152544.1XP_036008437.1  nuclear mitotic apparatus protein 1 isoform X5

    Conserved Domains (3) summary
    TIGR02168
    Location:4621231
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22298
    Location:17741832
    NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
    cl41774
    Location:159
    HkD_SF; Hook domain-containing proteins superfamily
  4. XM_036152541.1XP_036008434.1  nuclear mitotic apparatus protein 1 isoform X2

    UniProtKB/Swiss-Prot
    E9Q7G0, Q80Y35
    Conserved Domains (4) summary
    COG1196
    Location:11171713
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5541323
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22224
    Location:6151
    HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
    cd22298
    Location:18521910
    NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
  5. XM_006507175.4XP_006507238.1  nuclear mitotic apparatus protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006507238.1

    Conserved Domains (1) summary
    TIGR02168
    Location:5541323
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  6. XM_036152540.1XP_036008433.1  nuclear mitotic apparatus protein 1 isoform X2

    UniProtKB/Swiss-Prot
    E9Q7G0, Q80Y35
    Conserved Domains (4) summary
    COG1196
    Location:11171713
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5541323
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd22224
    Location:6151
    HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
    cd22298
    Location:18521910
    NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins