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EPHB2 EPH receptor B2 [ Canis lupus familiaris (dog) ]

Gene ID: 487380, updated on 17-Aug-2024

Summary

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Official Symbol
EPHB2provided by VGNC
Official Full Name
EPH receptor B2provided by VGNC
Primary source
VGNC:VGNC:40411
See related
Ensembl:ENSCAFG00845000323
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See EPHB2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (76986320..77110768, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (72932009..73056438, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (75819294..75943710, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (73807403..73931772, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (74815673..74940002, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene lactamase beta like 1 Neighboring gene testis expressed 46 Neighboring gene uncharacterized LOC111093615 Neighboring gene uncharacterized LOC119870432 Neighboring gene uncharacterized LOC119870434 Neighboring gene complement C1q B chain Neighboring gene complement C1q C chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane-ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system projection neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ephrin type-B receptor 2
XP_005617880.1
XP_005617881.1
XP_013966165.1
XP_038326722.1
XP_038326723.1
XP_038326724.1
XP_038387585.1
XP_038387586.1
XP_038387587.1
XP_038451815.1
XP_038451816.1
XP_038451817.1
XP_038451818.1
XP_038515894.1
XP_038515895.1
XP_038515896.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    76986320..77110768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038659968.1 → XP_038515896.1  ephrin type-B receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LXA4
    Conserved Domains (5) summary
    cd05065
    Location:563 → 831
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:857 → 927
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:303 → 398
    fn3; Fibronectin type III domain
    pfam14575
    Location:490 → 564
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_038659967.1 → XP_038515895.1  ephrin type-B receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L4K6, A0A8C0LXA4
    Conserved Domains (5) summary
    cd05065
    Location:593 → 861
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:887 → 957
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414 → 497
    fn3; Fibronectin type III domain
    pfam14575
    Location:521 → 594
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  3. XM_038659966.1 → XP_038515894.1  ephrin type-B receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LXA4
    Related
    ENSCAFP00845000356.1, ENSCAFT00845000518.1
    Conserved Domains (5) summary
    cd05065
    Location:594 → 862
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:888 → 958
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414 → 497
    fn3; Fibronectin type III domain
    pfam14575
    Location:521 → 595
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    73807403..73931772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038470796.1 → XP_038326724.1  ephrin type-B receptor 2 isoform X3

    Conserved Domains (5) summary
    cd05065
    Location:563 → 831
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:857 → 927
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:303 → 398
    fn3; Fibronectin type III domain
    pfam14575
    Location:490 → 564
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_038470795.1 → XP_038326723.1  ephrin type-B receptor 2 isoform X2

    Conserved Domains (5) summary
    cd05065
    Location:593 → 861
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:887 → 957
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414 → 497
    fn3; Fibronectin type III domain
    pfam14575
    Location:521 → 594
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  3. XM_038470794.1 → XP_038326722.1  ephrin type-B receptor 2 isoform X1

    Conserved Domains (5) summary
    cd05065
    Location:594 → 862
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:888 → 958
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414 → 497
    fn3; Fibronectin type III domain
    pfam14575
    Location:521 → 595
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    74815673..74940002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038595890.1 → XP_038451818.1  ephrin type-B receptor 2 isoform X7

  2. XM_038595889.1 → XP_038451817.1  ephrin type-B receptor 2 isoform X6

  3. XM_038595888.1 → XP_038451816.1  ephrin type-B receptor 2 isoform X5

  4. XM_038595887.1 → XP_038451815.1  ephrin type-B receptor 2 isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    75819294..75943710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038531659.1 → XP_038387587.1  ephrin type-B receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LXA4
    Conserved Domains (5) summary
    cd05065
    Location:563 → 831
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:857 → 927
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:303 → 398
    fn3; Fibronectin type III domain
    pfam14575
    Location:490 → 564
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_038531658.1 → XP_038387586.1  ephrin type-B receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L4K6, A0A8C0LXA4
    Conserved Domains (5) summary
    cd05065
    Location:593 → 861
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:887 → 957
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414 → 497
    fn3; Fibronectin type III domain
    pfam14575
    Location:521 → 594
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  3. XM_038531657.1 → XP_038387585.1  ephrin type-B receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LXA4
    Conserved Domains (5) summary
    cd05065
    Location:594 → 862
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:888 → 958
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414 → 497
    fn3; Fibronectin type III domain
    pfam14575
    Location:521 → 595
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    72932009..73056438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014110690.3 → XP_013966165.1  ephrin type-B receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LXA4
    Conserved Domains (5) summary
    cd05065
    Location:563 → 831
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:857 → 927
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:303 → 398
    fn3; Fibronectin type III domain
    pfam14575
    Location:490 → 564
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_005617824.4 → XP_005617881.1  ephrin type-B receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L4K6, A0A8C0LXA4
    Conserved Domains (5) summary
    cd05065
    Location:593 → 861
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:887 → 957
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414 → 497
    fn3; Fibronectin type III domain
    pfam14575
    Location:521 → 594
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  3. XM_005617823.4 → XP_005617880.1  ephrin type-B receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LXA4
    Conserved Domains (5) summary
    cd05065
    Location:594 → 862
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:888 → 958
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1 → 173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414 → 497
    fn3; Fibronectin type III domain
    pfam14575
    Location:521 → 595
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
Nucleotide Protein
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