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Ephb2 Eph receptor B2 [ Mus musculus (house mouse) ]

Gene ID: 13844, updated on 11-Apr-2024

Summary

Official Symbol
Ephb2provided by MGI
Official Full Name
Eph receptor B2provided by MGI
Primary source
MGI:MGI:99611
See related
Ensembl:ENSMUSG00000028664 AllianceGenome:MGI:99611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drt; Erk; Nuk; Cek5; Hek5; Qek5; Sek3; ETECK; Prkm5; Tyro5
Summary
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Broad expression in whole brain E14.5 (RPKM 18.7), CNS E14 (RPKM 13.6) and 18 other tissues See more
Orthologs
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Genomic context

See Ephb2 in Genome Data Viewer
Location:
4 D3; 4 69.0 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136374850..136563637, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136647536..136836326, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:136177240-136177540 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene testis expressed 46 Neighboring gene lactamase, beta-like 1 Neighboring gene STARR-seq mESC enhancer starr_11765 Neighboring gene STARR-seq mESC enhancer starr_11766 Neighboring gene STARR-seq mESC enhancer starr_11767 Neighboring gene VISTA enhancer mm1494 Neighboring gene predicted gene, 52708 Neighboring gene predicted gene, 31536 Neighboring gene complement component 1, q subcomponent, beta polypeptide Neighboring gene complement component 1, q subcomponent, C chain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables axon guidance receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane-ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane-ephrin receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within central nervous system projection neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in corpus callosum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hindbrain tangential cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NMDA glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection retraction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within optic nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NMDA glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic plasticity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic membrane assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of T-helper 17 type immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of body fluid levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse assembly EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in urogenital system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated intercellular transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in hippocampal mossy fiber to CA3 synapse IC
Inferred by Curator
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 
located_in synapse NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ephrin type-B receptor 2
Names
neural kinase
nuk receptor tyrosine kinase
tyrosine-protein kinase receptor EPH-3
tyrosine-protein kinase receptor SEK-3
NP_001277682.1
NP_034272.1
XP_006538594.1
XP_006538596.1
XP_006538597.1
XP_030109050.1
XP_030109051.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290753.2NP_001277682.1  ephrin type-B receptor 2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL671173, BC062924, CJ180821
    Consensus CDS
    CCDS71498.1
    UniProtKB/Swiss-Prot
    P54763
    Related
    ENSMUSP00000058135.8, ENSMUST00000059287.14
    Conserved Domains (5) summary
    cd05065
    Location:617885
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:911981
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437520
    fn3; Fibronectin type III domain
    pfam14575
    Location:549617
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. NM_010142.4NP_034272.1  ephrin type-B receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_034272.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AL671173, BC043088, CJ180821
    Consensus CDS
    CCDS18809.1
    UniProtKB/Swiss-Prot
    A3KG00, A3KG01, A3KG02, A3KG89, A3KG90, P54763, Q62213, Q6GTQ7, Q6P5F1, Q9QVY4
    Related
    ENSMUSP00000101471.3, ENSMUST00000105845.9
    Conserved Domains (5) summary
    cd05065
    Location:616884
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:910980
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437519
    fn3; Fibronectin type III domain
    pfam14575
    Location:548616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136374850..136563637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538534.4XP_006538597.1  ephrin type-B receptor 2 isoform X1

    Conserved Domains (5) summary
    cd05065
    Location:618886
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:912982
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437520
    fn3; Fibronectin type III domain
    pfam14575
    Location:549618
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. XM_030253190.2XP_030109050.1  ephrin type-B receptor 2 isoform X3

    Conserved Domains (5) summary
    cd05065
    Location:595863
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:889959
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414497
    fn3; Fibronectin type III domain
    pfam14575
    Location:526595
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. XM_030253191.2XP_030109051.1  ephrin type-B receptor 2 isoform X5

    Conserved Domains (5) summary
    cd05065
    Location:585853
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:879949
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:326419
    fn3; Fibronectin type III domain
    pfam14575
    Location:517585
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  4. XM_006538533.5XP_006538596.1  ephrin type-B receptor 2 isoform X4

    Conserved Domains (5) summary
    cd05065
    Location:586854
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:880950
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:326419
    fn3; Fibronectin type III domain
    pfam14575
    Location:517586
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  5. XM_006538531.5XP_006538594.1  ephrin type-B receptor 2 isoform X2

    UniProtKB/Swiss-Prot
    P54763
    Related
    ENSMUSP00000101472.3, ENSMUST00000105846.9
    Conserved Domains (5) summary
    cd05065
    Location:617885
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:911981
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437519
    fn3; Fibronectin type III domain
    pfam14575
    Location:548617
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain