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EPHB2 EPH receptor B2 [ Homo sapiens (human) ]

Gene ID: 2048, updated on 12-Aug-2018
Official Symbol
EPHB2provided by HGNC
Official Full Name
EPH receptor B2provided by HGNC
Primary source
HGNC:HGNC:3393
See related
Ensembl:ENSG00000133216 MIM:600997; Vega:OTTHUMG00000002881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5
Summary
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression
Broad expression in colon (RPKM 7.3), small intestine (RPKM 5.2) and 17 other tissues See more
Orthologs
See EPHB2 in Genome Data Viewer
Location:
1p36.12
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (22710770..22921500)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23037263..23241823)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene complement C1q C chain Neighboring gene complement C1q B chain Neighboring gene microRNA 4684 Neighboring gene microRNA 4253 Neighboring gene lactamase beta like 1 Neighboring gene testis expressed 46

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of EPH receptor B2 (EPHB2) in peptide-treated PBMCs PubMed
Nef nef HIV-1 Nef rapidly terminates ERK activation in the presence of TPA in a macrophage-inducing system PubMed

Go to the HIV-1, Human Interaction Database

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
    EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
  • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHB forward signaling, organism-specific biosystem
    EPHB forward signaling
  • EPHB-mediated forward signaling, organism-specific biosystem (from REACTOME)
    EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
  • Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
    Ephrin B reverse signaling, organism-specific biosystem
    Ephrin B reverse signaling
  • Ephrin signaling, organism-specific biosystem (from REACTOME)
    Ephrin signaling, organism-specific biosystemThe interaction between ephrin (EFN) ligands and EPH receptors results not only in forward signaling through the EPH receptor, but also in 'reverse' signaling through the EFN ligand itself. Reverse s...
  • EphrinB-EPHB pathway, organism-specific biosystem (from Pathway Interaction Database)
    EphrinB-EPHB pathway, organism-specific biosystem
    EphrinB-EPHB pathway
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • MAP kinase cascade, organism-specific biosystem (from BIOCYC)
    MAP kinase cascade, organism-specific biosystemThe MAP kinase cascade describes a sequence of phosphorylation events involving serine/threonine-specific protein kinases. Used by various signal transduction pathways, this cascade constitutes a com...
  • NLR Proteins, organism-specific biosystem (from WikiPathways)
    NLR Proteins, organism-specific biosystemMammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen associated-molecular-patterns (PAMPs...
  • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-2-mediated signaling events, organism-specific biosystem
    Syndecan-2-mediated signaling events
  • Transcriptional activation by NRF2, organism-specific biosystem (from WikiPathways)
    Transcriptional activation by NRF2, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4]. Nrf2 induces the expression of many antioxidant enzymes. It is therefore thought to be involved in ox...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC87492

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance receptor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane-ephrin receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
axonal fasciculation ISS
Inferred from Sequence or Structural Similarity
more info
 
camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
central nervous system projection neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 
commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
corpus callosum development ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
inactivation of MAPKK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
inner ear morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
learning ISS
Inferred from Sequence or Structural Similarity
more info
 
learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NMDA glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuron projection retraction IEA
Inferred from Electronic Annotation
more info
 
optic nerve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NMDA glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of body fluid levels ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
roof of mouth development ISS
Inferred from Sequence or Structural Similarity
more info
 
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
urogenital system development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynapse TAS
Traceable Author Statement
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
ephrin type-B receptor 2
Names
EPH-like kinase 5
developmentally-regulated Eph-related tyrosine kinase
elk-related tyrosine kinase
eph tyrosine kinase 3
protein-tyrosine kinase HEK5
renal carcinoma antigen NY-REN-47
tyrosine-protein kinase TYRO5
tyrosine-protein kinase receptor EPH-3
NP_001296121.1
NP_001296122.1
NP_004433.2
NP_059145.2
XP_006710504.1
XP_006710505.1
XP_024309663.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011804.2 RefSeqGene

    Range
    5001..215663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_780

mRNA and Protein(s)

  1. NM_001309192.1NP_001296121.1  ephrin type-B receptor 2 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
    Source sequence(s)
    AB210018, AK025975, AK125423, AK299701, AL035704, BC007903, BC018763, BC067861, CA417154, DB282024
    UniProtKB/TrEMBL
    B4DSE0, Q4LE53, Q6NVW1
    Conserved Domains (7) summary
    cd05065
    Location:558826
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:852922
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    smart00454
    Location:852919
    SAM; Sterile alpha motif
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437520
    fn3; Fibronectin type III domain
    pfam07714
    Location:563822
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:519558
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. NM_001309193.1NP_001296122.1  ephrin type-B receptor 2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001296122.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site at an internal exon and alternate splice sites in the 3' coding region and 3' UTR, which results in a longer and novel 3' coding region compared to variant 2. It encodes isoform 4, which is longer than and has a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AB210018, AF025304, AK025975, AK125423, AL035704, BC067861, CA417154, DB282024
    Consensus CDS
    CCDS81279.1
    UniProtKB/Swiss-Prot
    P29323
    UniProtKB/TrEMBL
    Q4LE53, Q6NVW1
    Related
    ENSP00000383053.3, OTTHUMP00000002915, ENST00000400191.7, OTTHUMT00000008060
    Conserved Domains (7) summary
    cd05065
    Location:616884
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:910980
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    smart00454
    Location:910977
    SAM; Sterile alpha motif
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437520
    fn3; Fibronectin type III domain
    pfam07714
    Location:621880
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:548616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. NM_004442.7NP_004433.2  ephrin type-B receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_004433.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. It encodes isoform 2.
    Source sequence(s)
    AK025975, AL035704, BC067861, DB282024, L41939
    Consensus CDS
    CCDS230.1
    UniProtKB/Swiss-Prot
    P29323
    UniProtKB/TrEMBL
    Q6NVW1
    Related
    ENSP00000363763.3, OTTHUMP00000002916, ENST00000374632.7, OTTHUMT00000008061
    Conserved Domains (7) summary
    cd05065
    Location:617885
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:911981
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    smart00454
    Location:911978
    SAM; Sterile alpha motif
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437520
    fn3; Fibronectin type III domain
    pfam07714
    Location:622881
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:548617
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  4. NM_017449.4NP_059145.2  ephrin type-B receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_059145.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 2. It encodes isoform 1, which is shorter than isoform 2.
    Source sequence(s)
    AB210018, AF025304, AK025975, AK125423, AL035704, BC067861, CA417154, DB282024
    Consensus CDS
    CCDS229.2
    UniProtKB/Swiss-Prot
    P29323
    UniProtKB/TrEMBL
    Q4LE53, Q6NVW1
    Related
    ENSP00000363761.3, OTTHUMP00000002914, ENST00000374630.7, OTTHUMT00000008059
    Conserved Domains (7) summary
    cd05065
    Location:616884
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:910980
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    smart00454
    Location:910977
    SAM; Sterile alpha motif
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437520
    fn3; Fibronectin type III domain
    pfam07714
    Location:621880
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:548616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    22710770..22921500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710442.4XP_006710505.1  ephrin type-B receptor 2 isoform X2

    Conserved Domains (7) summary
    cd05065
    Location:586854
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:880950
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    smart00454
    Location:880947
    SAM; Sterile alpha motif
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:326421
    fn3; Fibronectin type III domain
    pfam07714
    Location:591850
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:517586
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. XM_006710441.4XP_006710504.1  ephrin type-B receptor 2 isoform X1

    Related
    ENSP00000363758.1, ENST00000374627.1
    Conserved Domains (7) summary
    cd05065
    Location:610878
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:904974
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    smart00454
    Location:904971
    SAM; Sterile alpha motif
    cd10477
    Location:12189
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:430513
    fn3; Fibronectin type III domain
    pfam07714
    Location:615874
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:541610
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. XM_024453895.1XP_024309663.1  ephrin type-B receptor 2 isoform X3

    Conserved Domains (4) summary
    cd05065
    Location:175443
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:469539
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    pfam00041
    Location:179
    fn3; Fibronectin type III domain
    pfam14575
    Location:107175
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
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