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NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 4734, updated on 13-Jan-2019

Summary

Official Symbol
NEDD4provided by HGNC
Official Full Name
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:7727
See related
Ensembl:ENSG00000069869 MIM:602278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPF1; NEDD4-1
Summary
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in placenta (RPKM 6.4), liver (RPKM 5.9) and 23 other tissues See more
Orthologs

Genomic context

See NEDD4 in Genome Data Viewer
Location:
15q21.3
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (55826917..55993746, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (56119120..56285835, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene pygopus family PHD finger 1 Neighboring gene protogenin Neighboring gene NEDD4 intron nontranscribed DNase I hypersensitive site-defined enhancer Neighboring gene CCR4-NOT transcription complex subunit 6-like pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 568, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.
NHGRI GWA Catalog
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells PubMed
Envelope surface glycoprotein gp160, precursor env Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells PubMed
Nef nef HIV-1 Nef co-localizes with CXCR4, AIP4, NEDD4, CD63/LAMP-1-positive vesicles, and HRS/VPS27-positive ESCRT-0 structures in HeLa cells PubMed
nef HIV-1 Nef co-localizes with E3 ubiquitin ligases AIP4 and NEDD4. HIV-1 Nef induced degradation of GNAI2 involves AIP4 and NEDD4 through recruitment of AIP4 and NEDD4 by Nef PubMed
Pr55(Gag) gag Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells PubMed
gag Overexpression of Nedd4-1 rescues the HIV-1 PTAP- mutant budding defects and the ubiquitin ligase activity of Nedd4-1 and the LYPXnL motif of Gag/p6 are required for the Nedd4-1-mediated rescue PubMed
gag Nedd4 is one possible ubiquitin ligase implicated to interact with the L domain of HIV-1 p6-Gag resulting in monoubiquitination of p6 PubMed
gag Nedd4-1 facilitation of HIV-1 PTAP(-) release requires basic residues in Gag/NC PubMed
gag The leucine residues (211LYPL214 motif) within the C2 domain of Nedd4-1 mediate binding to Gag and play a critical role in Nedd4-1-mediated rescue of HIV-1 PTAP(-) PubMed
gag Ubiquitination of HIV-1 p6-Gag may be important for proper virus release from cells PubMed
gag The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6 PubMed
Vif vif HIV-1 Vif, through amino acids 20-128, binds to the WW domains of hNedd4 and AIP4, two HECT E3 ubiquitin ligases PubMed
capsid gag Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells. NEDD4-induced upregulation of p24 levels is mediated by the C2 domain (residues 20-151) of NEDD4 PubMed
p6 gag Overexpression of Nedd4-1 rescues the HIV-1 PTAP- mutant budding defects and the ubiquitin ligase activity of Nedd4-1 and the LYPXnL motif of Gag/p6 are required for the Nedd4-1-mediated rescue PubMed
gag Nedd4 is one possible ubiquitin ligase implicated to interact with the L domain of HIV-1 p6-Gag resulting in monoubiquitination of p6 PubMed
gag Ubiquitination of HIV-1 p6-Gag may be important for proper virus release from cells PubMed
gag The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Downregulation of ERBB4 signaling, organism-specific biosystem (from REACTOME)
    Downregulation of ERBB4 signaling, organism-specific biosystemWW-domain binding motifs in the C-tail of ERBB4 play an important role in the downregulation of ERBB4 receptor signaling, enabling the interaction of intact ERBB4, ERBB4 m80 and ERBB4 s80 with NEDD4 ...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    ErbB4 signaling events, organism-specific biosystem
    ErbB4 signaling events
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
    Presenilin action in Notch and Wnt signaling, organism-specific biosystem
    Presenilin action in Notch and Wnt signaling
  • Proteasome Degradation, organism-specific biosystem (from WikiPathways)
    Proteasome Degradation, organism-specific biosystem
    Proteasome Degradation
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
  • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
    Signaling events mediated by VEGFR1 and VEGFR2
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0093, MGC176705

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-2 adrenergic receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
phosphoserine residue binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphothreonine residue binding ISS
Inferred from Sequence or Structural Similarity
more info
 
proline-rich region binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
proline-rich region binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
T cell activation IEA
Inferred from Electronic Annotation
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
development involved in symbiotic interaction IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardial cushion development IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of sodium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection development IEP
Inferred from Expression Pattern
more info
PubMed 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
progesterone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to lysosome IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
receptor catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of macroautophagy TAS
Traceable Author Statement
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of potassium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to calcium ion TAS
Traceable Author Statement
more info
PubMed 
transmission of virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
apicolateral plasma membrane TAS
Traceable Author Statement
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase NEDD4
Names
HECT-type E3 ubiquitin transferase NEDD4
cell proliferation-inducing gene 53 protein
receptor-potentiating factor 1
NP_001271267.1
NP_001271268.1
NP_001271269.1
NP_001316141.1
NP_006145.2
NP_940682.2
XP_011519926.1
XP_011519927.1
XP_011519928.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051072.1 RefSeqGene

    Range
    5001..171830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001284338.1NP_001271267.1  E3 ubiquitin-protein ligase NEDD4 isoform 3

    See identical proteins and their annotated locations for NP_001271267.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains three alternate in-frame exons, compared to variant 2. The encoded isoform (3) is longer than isoform 2.
    Source sequence(s)
    AC009997, AL832063, BC136605, BC144285
    Consensus CDS
    CCDS61644.1
    UniProtKB/Swiss-Prot
    P46934
    Related
    ENSP00000424827.1, ENST00000508342.5
    Conserved Domains (5) summary
    smart00456
    Location:893925
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:9861315
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:9621316
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:769798
    WW; WW domain
    cl14603
    Location:517570
    C2; C2 domain
  2. NM_001284339.1NP_001271268.1  E3 ubiquitin-protein ligase NEDD4 isoform 4

    See identical proteins and their annotated locations for NP_001271268.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 2. The encoded isoform (4) is longer than isoform 2.
    Source sequence(s)
    AC009997, AL832063, BC136605, BC144285
    Consensus CDS
    CCDS61643.1
    UniProtKB/Swiss-Prot
    P46934
    Related
    ENSP00000422705.1, ENST00000506154.1
    Conserved Domains (5) summary
    smart00456
    Location:877909
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:9701299
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:9461300
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:753782
    WW; WW domain
    cl14603
    Location:517570
    C2; C2 domain
  3. NM_001284340.1NP_001271269.1  E3 ubiquitin-protein ligase NEDD4 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains two alternate in-frame exons, compared to variant 2. The encoded isoform (5) is longer than isoform 2.
    Source sequence(s)
    AC009997, AL832063, AL832359, BC136605, BC144285
    UniProtKB/Swiss-Prot
    P46934
    Conserved Domains (5) summary
    smart00456
    Location:876908
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:9691298
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:9451299
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:752781
    WW; WW domain
    cl14603
    Location:513553
    C2; C2 domain
  4. NM_001329212.1NP_001316141.1  E3 ubiquitin-protein ligase NEDD4 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains multiple exons in the 5' UTR, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AC009997, AC039057, AL832063, AL833300, D42055, DB451823
    UniProtKB/Swiss-Prot
    P46934
    Related
    ENSP00000422455.1, ENST00000508871.5
  5. NM_006154.3NP_006145.2  E3 ubiquitin-protein ligase NEDD4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains multiple alternate 5' coding exons, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (1) is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AC009997, AL832063, AL833300, D42055, DB451823
    Consensus CDS
    CCDS45265.1
    UniProtKB/Swiss-Prot
    P46934
    Related
    ENSP00000410613.3, ENST00000435532.7
    Conserved Domains (5) summary
    cd04033
    Location:20151
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:474506
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:567896
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:543897
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:350379
    WW; WW domain
  6. NM_198400.3NP_940682.2  E3 ubiquitin-protein ligase NEDD4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform 2.
    Source sequence(s)
    AC009997, AL832063, AL833300, BC035707, BC136605
    Consensus CDS
    CCDS10156.1
    UniProtKB/Swiss-Prot
    P46934
    Related
    ENSP00000345530.2, ENST00000338963.6
    Conserved Domains (4) summary
    smart00456
    Location:821853
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:9141243
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:8901244
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:697726
    WW; WW domain

RNA

  1. NR_104302.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two internal exons and contains an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC009997, AL832063, AL832359, AL833293, BC136605, BC144285
    Related
    ENST00000503468.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    55826917..55993746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521625.3XP_011519927.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

    See identical proteins and their annotated locations for XP_011519927.1

    Conserved Domains (5) summary
    cd04033
    Location:1100
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:423455
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:516845
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:492846
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:299328
    WW; WW domain
  2. XM_011521626.1XP_011519928.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

    See identical proteins and their annotated locations for XP_011519928.1

    Conserved Domains (5) summary
    cd04033
    Location:1100
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:423455
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:516845
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:492846
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:299328
    WW; WW domain
  3. XM_011521624.3XP_011519926.1  E3 ubiquitin-protein ligase NEDD4 isoform X1

    Conserved Domains (5) summary
    cd04033
    Location:15126
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:449481
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:542871
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:518872
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:325354
    WW; WW domain
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