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NDUFA10 NADH:ubiquinone oxidoreductase subunit A10 [ Homo sapiens (human) ]

Gene ID: 4705, updated on 22-Sep-2022

Summary

Official Symbol
NDUFA10provided by HGNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit A10provided by HGNC
Primary source
HGNC:HGNC:7684
See related
Ensembl:ENSG00000130414 MIM:603835; AllianceGenome:HGNC:7684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CI-42k; CI-42KD; MC1DN22
Summary
The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in heart (RPKM 10.9), kidney (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See NDUFA10 in Genome Data Viewer
Location:
2q37.3
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (239892442..240025342, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (240386242..240518068, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (240831859..240964759, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373966 Neighboring gene uncharacterized LOC150935 Neighboring gene microRNA 4786 Neighboring gene olfactory receptor family 6 subfamily B member 2 Neighboring gene olfactory receptor family 6 subfamily B member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Mitochondrial complex 1 deficiency, nuclear type 22
MedGen: C4748796 OMIM: 618243 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Identification of regions associated with variation in sensitivity to food-related odors in the human genome.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 (NDUFA10) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5103, FLJ21923

Gene Ontology Provided by GOA

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Names
NADH-ubiquinone oxidoreductase 42 kDa subunit
complex I 42kDa subunit
NP_001308948.1
NP_001308949.1
NP_004535.1
XP_011509530.1
XP_047300443.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031855.2 RefSeqGene

    Range
    5061..73031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322019.2NP_001308948.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC013469
    UniProtKB/TrEMBL
    H7C2X4
    Related
    ENSP00000408224.2, ENST00000448880.6
    Conserved Domains (1) summary
    cd02030
    Location:59277
    NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...
  2. NM_001322020.2NP_001308949.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC013469, AC114750
    UniProtKB/TrEMBL
    A0A7I2V438
    Related
    ENSP00000503837.1, ENST00000679158.1
    Conserved Domains (1) summary
    cd02030
    Location:59277
    NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...
  3. NM_001410987.1NP_001397916.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC013469, AC114750
  4. NM_004544.4NP_004535.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_004535.1

    Status: REVIEWED

    Source sequence(s)
    AC013469, AC114750, AK025576
    Consensus CDS
    CCDS2531.1
    UniProtKB/Swiss-Prot
    O95299, Q8WXC9
    UniProtKB/TrEMBL
    A0A024R4B3
    Related
    ENSP00000252711.2, ENST00000252711.7
    Conserved Domains (1) summary
    cd02030
    Location:59277
    NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...

RNA

  1. NR_136155.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB209440, AC114750, AK025576, BP208667
    Related
    ENST00000678562.1
  2. NR_136156.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC013469, AC114750
  3. NR_136157.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC013469, AC114750
  4. NR_136158.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC013469, AC114750, AC233275
    Related
    ENST00000677057.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    239892442..240025342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511228.4XP_011509530.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1

    UniProtKB/TrEMBL
    H7C1Y7
    Related
    ENSP00000403080.2, ENST00000444548.6
    Conserved Domains (1) summary
    cd02030
    Location:59277
    NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...
  2. XM_047444487.1XP_047300443.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A7I2V5L0
    Related
    ENSP00000504547.1, ENST00000677764.1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_011332689.1 Reference GRCh38.p14 PATCHES

    Range
    195545..198421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    240386242..240518068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)