IL17A interleukin 17A [Sus scrofa (pig)] - Gene

Summary

Official Symbol: IL17Aprovided by VGNC
Official Full Name: interleukin 17Aprovided by VGNC
Primary source: VGNC:VGNC:113081
See related: Ensembl:ENSSSCG00000001748 RGD:14115550
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: IL17
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2026_06	current	Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1)	7	NC_139389.1 (54551790..54601780)
106	previous assembly	Sscrofa11.1 (GCF_000003025.6)	7	NC_010449.5 (46013584..46017161)

Chromosome 7 - NC_139389.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study provides evidence that IL-1beta combined with IL-17A promoted chronic inflammatory arthritis by activating the catabolic processes accompanied with the suppression of cartilage anabolism. These suggest that further applications, which suppress inflammatory enhancers, especially IL-17A, should be considered as a target for arthritis research and therapy.
Title: Proinflammatory Effects of IL-1β Combined with IL-17A Promoted Cartilage Degradation and Suppressed Genes Associated with Cartilage Matrix Synthesis In Vitro.
At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.
Title: Crusted scabies is associated with increased IL-17 secretion by skin T cells.
Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.
Title: Effects of dietary supplementation with Laminaria hyperborea, Laminaria digitata, and Saccharomyces cerevisiae on the IL-17 pathway in the porcine colon.
conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3(+)CD4(+) and CD3(+)gammadeltaTCR(+).
Title: CD4+ and γδTCR+ T lymphocytes are sources of interleukin-17 in swine.
Cloning and expression of interleukin-17.
Title: Cloning and characterization of Swine interleukin-17, preferentially expressed in the intestines.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-17A

Names: IL-17; IL-17A; interleukin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.