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Il17a interleukin 17A [ Mus musculus (house mouse) ]

Gene ID: 16171, updated on 30-Nov-2021

Summary

Official Symbol
Il17aprovided by MGI
Official Full Name
interleukin 17Aprovided by MGI
Primary source
MGI:MGI:107364
See related
Ensembl:ENSMUSG00000025929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il17; Ctla8; IL-17; Ctla-8; IL-17A
Summary
This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Il17a in Genome Data Viewer
Location:
1; 1 A4
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (20801129..20804720)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (20730905..20734496)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (20720986..20724577)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA of muscle differentiation 1 Neighboring gene microRNA 206 Neighboring gene microRNA 133b Neighboring gene interleukin 17F Neighboring gene minichromosome maintenance complex component 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fibroblast activation ISO
Inferred from Sequence Orthology
more info
 
involved_in granulocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-17-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of antimicrobial peptide production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-16 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-23 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-17A
Names
cytotoxic T-lymphocyte-associated antigen 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010552.3NP_034682.1  interleukin-17A precursor

    See identical proteins and their annotated locations for NP_034682.1

    Status: REVIEWED

    Source sequence(s)
    AK040420
    Consensus CDS
    CCDS14842.1
    UniProtKB/Swiss-Prot
    Q62386
    UniProtKB/TrEMBL
    Q544E6
    Related
    ENSMUSP00000027061.5, ENSMUST00000027061.5
    Conserved Domains (1) summary
    pfam06083
    Location:72150
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    20801129..20804720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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