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IL17A interleukin 17A [ Homo sapiens (human) ]

Gene ID: 3605, updated on 18-Apr-2021

Summary

Official Symbol
IL17Aprovided by HGNC
Official Full Name
interleukin 17Aprovided by HGNC
Primary source
HGNC:HGNC:5981
See related
Ensembl:ENSG00000112115 MIM:603149
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL17; CTLA8; IL-17; CTLA-8; IL-17A
Summary
This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IL17A in Genome Data Viewer
Location:
6p12.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (52186375..52190638)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52051173..52055436)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene microRNA 206 Neighboring gene long intergenic non-protein coding RNA, muscle differentiation 1 Neighboring gene microRNA 133b Neighboring gene uncharacterized LOC102724327 Neighboring gene interleukin 17F

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 IIIB Env (gp120) upregulates production of TNF (TNF-a), IL-17A, CCL2 (MCP1), CCL5 (RANTES), IL6, IL10, CXCL8 (IL8), CXCL1 (GRO-a), and CCL1 (I309) in stimulated monocyte derived macrophages PubMed
Tat tat Inhibition of clathrin-mediated endocytosis by chlorpromazine results in complete inhibition of HIV-1 Tat-mediated IL17 secretion in human primary T cells PubMed
tat HIV-1 Tat-induced upregulation of IL17 expression is dependent upon the VEGFR2 signaling pathway in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell death TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
fibroblast activation IDA
Inferred from Direct Assay
more info
PubMed 
granulocyte migration IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-17-mediated signaling pathway TAS
Traceable Author Statement
more info
 
intestinal epithelial structure maintenance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of antimicrobial peptide production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine (C-X-C motif) ligand 1 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-16 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-23 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-17A
Names
cytotoxic T-lymphocyte-associated antigen 8
cytotoxic T-lymphocyte-associated protein 8
interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033021.1 RefSeqGene

    Range
    4989..9252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1223

mRNA and Protein(s)

  1. NM_002190.3NP_002181.1  interleukin-17A precursor

    See identical proteins and their annotated locations for NP_002181.1

    Status: REVIEWED

    Source sequence(s)
    AL391221, U32659
    Consensus CDS
    CCDS4937.1
    UniProtKB/Swiss-Prot
    Q16552
    Related
    ENSP00000497968.1, ENST00000648244.1
    Conserved Domains (1) summary
    pfam06083
    Location:69147
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    52186375..52190638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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