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TMEM41B transmembrane protein 41B [ Homo sapiens (human) ]

Gene ID: 440026, updated on 9-Feb-2020

Summary

Official Symbol
TMEM41Bprovided by HGNC
Official Full Name
transmembrane protein 41Bprovided by HGNC
Primary source
HGNC:HGNC:28948
See related
Ensembl:ENSG00000166471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in duodenum (RPKM 11.2), thyroid (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See TMEM41B in Genome Data Viewer
Location:
11p15.4
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (9280654..9314633, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9302201..9336315, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9656 Neighboring gene DENN domain containing 5A Neighboring gene tRNA-Leu (CAA) 5-1 Neighboring gene proline rich 13 pseudogene 2 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC644656

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0033, MGC33897, MGC57262

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 41B
Names
stasimon

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165030.3NP_001158502.1  transmembrane protein 41B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks a large portion of the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BE673436, DA149513, DR157551
    Consensus CDS
    CCDS53600.1
    UniProtKB/Swiss-Prot
    Q5BJD5
    Related
    ENSP00000436480.1, ENST00000533723.1
  2. NM_015012.4NP_055827.1  transmembrane protein 41B isoform 1

    See identical proteins and their annotated locations for NP_055827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC055845, BI829492, D26067
    Consensus CDS
    CCDS31424.1
    UniProtKB/Swiss-Prot
    Q5BJD5
    Related
    ENSP00000433126.1, ENST00000528080.6
    Conserved Domains (1) summary
    pfam09335
    Location:129248
    SNARE_assoc; SNARE associated Golgi protein

RNA

  1. NR_028491.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC091524, BI829492, N54391

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    9280654..9314633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_930870.1 RNA Sequence

  2. XR_001747881.1 RNA Sequence

    Related
    ENST00000524543.5
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