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TMEM41B transmembrane protein 41B [ Homo sapiens (human) ]

Gene ID: 440026, updated on 17-Jun-2024

Summary

Official Symbol
TMEM41Bprovided by HGNC
Official Full Name
transmembrane protein 41Bprovided by HGNC
Primary source
HGNC:HGNC:28948
See related
Ensembl:ENSG00000166471 MIM:620271; AllianceGenome:HGNC:28948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in autophagosome assembly. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in duodenum (RPKM 11.2), thyroid (RPKM 10.7) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM41B in Genome Data Viewer
Location:
11p15.4
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (9280654..9314593, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (9365480..9400673, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9302201..9336140, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9656 Neighboring gene DENN domain containing 5A Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:9190693-9191892 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9250779-9251379 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:9251982-9252582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9273812-9274511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4405 Neighboring gene MPRA-validated peak1192 silencer Neighboring gene tRNA-Leu (CAA) 5-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9335331-9335848 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:9335849-9336364 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9339994-9340970 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:9340971-9341947 Neighboring gene proline rich 13 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9372391-9372892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9376493-9376993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9377088-9377646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9377647-9378203 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:9385258-9386457 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9406201-9406716 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:9420900-9421065 Neighboring gene importin 7 Neighboring gene Sharpr-MPRA regulatory region 11606 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9480928-9481563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4408 Neighboring gene uncharacterized LOC644656

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0033, MGC33897, MGC57262

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular lipid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation by host of viral RNA genome replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma membrane phospholipid scrambling IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 41B
Names
protein stasimon
stasimon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165030.3NP_001158502.1  transmembrane protein 41B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks a large portion of the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BE673436, DA149513, DR157551
    Consensus CDS
    CCDS53600.1
    UniProtKB/Swiss-Prot
    Q5BJD5
    Related
    ENSP00000436480.1, ENST00000533723.1
  2. NM_015012.4NP_055827.1  transmembrane protein 41B isoform 1

    See identical proteins and their annotated locations for NP_055827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC055845, BI829492, D26067
    Consensus CDS
    CCDS31424.1
    UniProtKB/Swiss-Prot
    D3DQU9, E9PP29, Q15055, Q4G0P0, Q5BJD5
    UniProtKB/TrEMBL
    B4E0E0
    Related
    ENSP00000433126.1, ENST00000528080.6
    Conserved Domains (1) summary
    pfam09335
    Location:129248
    SNARE_assoc; SNARE associated Golgi protein

RNA

  1. NR_028491.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC091524, BI829492, N54391

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    9280654..9314593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426969.1XP_047282925.1  transmembrane protein 41B isoform X1

    Related
    ENSP00000431934.1, ENST00000524543.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    9365480..9400673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368846.1XP_054224821.1  transmembrane protein 41B isoform X2

    UniProtKB/Swiss-Prot
    D3DQU9, E9PP29, Q15055, Q4G0P0, Q5BJD5
    UniProtKB/TrEMBL
    B4E0E0
  2. XM_054368847.1XP_054224822.1  transmembrane protein 41B isoform X1

RNA

  1. XR_008488399.1 RNA Sequence