U.S. flag

An official website of the United States government


Send to:

Choose Destination

MRC1 mannose receptor C-type 1 [ Homo sapiens (human) ]

Gene ID: 4360, updated on 18-Dec-2022


Official Symbol
MRC1provided by HGNC
Official Full Name
mannose receptor C-type 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000260314 MIM:153618; AllianceGenome:HGNC:7228
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
Annotation information
Note: In the NCBI Build 37.2 reference assembly, MRC1 and MRC1L1 are duplicate genes in close proximity to each other on chromosome 10. In July 2010, the Genome Reference Consortium determined that the region contains a duplication error. Two of the clones on which MRC1L1 was based (AL928580, BX255924) will be removed from the reference assembly and only MRC1 will be present in the assembly. [13 Feb 2013]
Broad expression in lung (RPKM 50.7), spleen (RPKM 28.0) and 19 other tissues See more
Try the new Gene table
Try the new Transcript table

Genomic context

See MRC1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17809348..17911164)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17828682..17930487)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18098337..18200093)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene signal transducing adaptor molecule Neighboring gene transmembrane protein 236 Neighboring gene U4 spliceosomal RNA Neighboring gene microRNA 511 Neighboring gene solute carrier family 39 member 12 Neighboring gene SLC39A12 antisense RNA 1 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 2 Neighboring gene uncharacterized LOC107984213

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mannose receptor, C type 1 (MRC1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binds to mannose receptor on vaginal epithelial cells PubMed
env Mannose receptor (MR) dimers bind to soluble monomeric and trimeric HIV envelope and to HIV virion in capture assay PubMed
env Recombinant HIV-1 gp120 blocks Mannose Receptor-mediated phagocytosis in human and murine macrophages and microglial cells PubMed
env HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin PubMed
env HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes PubMed
Nef nef HIV-1 Nef downregulates mannose receptor (MR) on the surface of macrophages and dendritic cells (DC); both NTLY and SDXXXL motifs in the cytoplasmic tail of MR are critical for the cell surface reduction of MR PubMed
Tat tat HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters PubMed
tat HIV-1 Tat represses transcription from the rat mannose receptor promoter, thereby downregulating expression of mannose receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC181940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cargo receptor activity IDA
Inferred from Direct Assay
more info
enables mannose binding IEA
Inferred from Electronic Annotation
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
located_in endosome membrane IDA
Inferred from Direct Assay
more info
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane IDA
Inferred from Direct Assay
more info
located_in plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
macrophage mannose receptor 1
C-type lectin domain family 13 member D
human mannose receptor
macrophage mannose receptor 1-like protein 1
mannose receptor, C type 1-like 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_047011.1 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002438.4NP_002429.1  macrophage mannose receptor 1 precursor

    See identical proteins and their annotated locations for NP_002429.1

    Status: REVIEWED

    Source sequence(s)
    AC069023, AL139238, AV659122, DC296466, J05550
    Consensus CDS
    P22897, Q5VSK2
    ENSP00000455897.1, ENST00000569591.3
    Conserved Domains (5) summary
    FN2; Fibronectin type 2 domain
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    RICIN; Ricin-type beta-trefoil
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060934.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009567.1: Suppressed sequence

    NM_001009567.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.