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Mrc1 mannose receptor, C type 1 [ Mus musculus (house mouse) ]

Gene ID: 17533, updated on 22-Jan-2023

Summary

Official Symbol
Mrc1provided by MGI
Official Full Name
mannose receptor, C type 1provided by MGI
Primary source
MGI:MGI:97142
See related
Ensembl:ENSMUSG00000026712 AllianceGenome:MGI:97142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MR; CD206
Summary
Enables mannose binding activity and transmembrane signaling receptor activity. Acts upstream of or within cellular response to interferon-gamma; cellular response to interleukin-4; and cellular response to lipopolysaccharide. Located in cell surface. Is expressed in several structures, including hemolymphoid system; intestine; liver; lung; and yolk sac. Orthologous to human MRC1 (mannose receptor C-type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 7.7), placenta adult (RPKM 4.9) and 22 other tissues See more
Orthologs
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Genomic context

See Mrc1 in Genome Data Viewer
Location:
2 A2; 2 10.46 cM
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (14234225..14336834)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (14229414..14332023)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 Neighboring gene transmembrane protein 236 Neighboring gene microRNA 511 Neighboring gene solute carrier family 39 (zinc transporter), member 12 Neighboring gene predicted gene 13266

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables cargo receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables mannose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
macrophage mannose receptor 1
Names
MMR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008625.2NP_032651.2  macrophage mannose receptor 1 precursor

    See identical proteins and their annotated locations for NP_032651.2

    Status: VALIDATED

    Source sequence(s)
    AK079897, AL845290, BE197931, Z11974
    Consensus CDS
    CCDS15700.1
    UniProtKB/Swiss-Prot
    Q61830, Q8C502
    UniProtKB/TrEMBL
    Q2HZ94
    Related
    ENSMUSP00000028045.3, ENSMUST00000028045.4
    Conserved Domains (5) summary
    smart00059
    Location:161209
    FN2; Fibronectin type 2 domain
    cd00037
    Location:659779
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:362487
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:27142
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:34140
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    14234225..14336834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)