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CAPN8 calpain 8 [ Gallus gallus (chicken) ]

Gene ID: 428561, updated on 17-Aug-2024

Summary

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Official Symbol
CAPN8provided by CGNC
Official Full Name
calpain 8provided by CGNC
Primary source
CGNC:7133
See related
Ensembl:ENSGALG00010016656
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
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Genomic context

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Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (17394817..17422927)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (17310105..17338152)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene tumor protein p53 binding protein 2 Neighboring gene F-box protein 28 Neighboring gene calpain 2 Neighboring gene sushi domain containing 4 Neighboring gene toll like receptor 5 Neighboring gene uncharacterized LOC421332

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-8
XP_040523490.1
XP_040523491.1
XP_040554053.1
XP_426117.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    17394817..17422927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_426117.7 → XP_426117.2  calpain-8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z3Y1, F1P052
    Related
    ENSGALP00010023284.1, ENSGALT00010040159.1
    Conserved Domains (4) summary
    PTZ00184
    Location:534 → 670
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:579 → 634
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:46 → 342
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:356 → 509
    Calpain_III; Calpain large subunit, domain III

  2. XM_040698119.2 → XP_040554053.1  calpain-8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z3Y1
    Conserved Domains (3) summary
    smart00230
    Location:32 → 352
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:355 → 512
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16191
    Location:535 → 701
    EFh_PEF_CAPN8; Penta-EF hand, calcium binding motifs, found in calpain-8 (CAPN8)

RNA

  1. XR_005858648.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    17310105..17338152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040667557.2 → XP_040523491.1  calpain-8 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z3Y1
    Conserved Domains (3) summary
    smart00230
    Location:32 → 352
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:355 → 512
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16191
    Location:535 → 702
    EFh_PEF_CAPN8; Penta-EF hand, calcium binding motifs, found in calpain-8 (CAPN8)

  2. XM_040667556.2 → XP_040523490.1  calpain-8 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z3Y1
    Conserved Domains (3) summary
    smart00230
    Location:32 → 352
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:355 → 512
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16191
    Location:535 → 701
    EFh_PEF_CAPN8; Penta-EF hand, calcium binding motifs, found in calpain-8 (CAPN8)

RNA

  1. XR_005848329.2 RNA Sequence

Nucleotide Protein
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