1KFU


Conserved Protein Domain Family
Calpain_III
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cd00214: Calpain_III 
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Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are separated by C2-like domain III. Domain III plays an important role in calcium-induced activation of calpain involving electrostatic interactions with subdomain II. Proposed to mediate calpain's interaction with phospholipids and translocation to cytoplasmic/nuclear membranes. CD includes subdomain III of typical and atypical calpains.
Links
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Statistics
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PSSM-Id: 238132
Aligned: 25 rows
Threshold Bit Score: 131.267
Created: 24-May-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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acidic loop
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:acidic loop
Evidence:
  • Comment:residues of acidic loop form several salt bridges involved in Ca2+-dependent calpain activation
  • Comment:not found in all members
  • Structure:1KFU_L; subdomain II-III salt bridges important in Ca2+-induced activation of calpain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                    ###          #                    
1KFU_L     353 KKWKLTKMDGNWRRg--------STAGGCrNYPNTFWMNPQYLIKLEEEdedeedgesgCTFLVGLIQKhrrrqr----- 419  human
AAF48591   708 LHWKMKMHQGQWKRg--------VTAGGC-RNHESFHINPQLLISVQDE----------QDLVIALNQHtav-------- 760  fruit fly
NP_493052  468 QQWIQASFEGEWSSr-------iGTAGGC-DDHDTFCTNLQYEIHFRATdsyd--snhkCTIIAALFQKnrdhcv----- 532  Caenorhabditis e...
NP_500081  473 KQWIQKSADGEWCSr-------kGTAGGCsNNENTFCTNPQYETYFRATspss---ndkCTVIAAVFQKyrrnql----- 537  Caenorhabditis e...
13959310   349 GRKELESVVGCWTVddd---plmNRSGGCyNNRDTFLQNPQYIFTVPEDg---------HKVIMSLQQKdlrtyrr---- 412  house mouse
2065242    352 KTWEEARLHGAWTRhed---pqqNRSGGCiNHKDTFFQNPQYVFEVKKPe---------DEVLISIQQRpkrstrr---- 415  house mouse
NP_502751  362 RSYDEQIVFSEWTTngkksgapdDRAGGChNFKATFCNNPQYIFDIPSPn---------CSVMFALIQNdpsegl----- 427  Caenorhabditis e...
NP_175932 1997 VPQMRYSVNGQWRG---------YSAGGC-QDYSSWHQNPQFRLRATGSda-------sLPIHGVGFSRttpgfrny--- 2056 thale cress
Q9HC96     335 LLCHTRALPGAWVKg--------QSAGGC-RNNSGFPSNPKFWLRVSEP----------SEVYIAVLQRsrlhaadwagr 395  human
NP_075573  335 LLCHTRALPGAWVKg--------QSAGGC-RNNSGFPSNPKFWLRVSKP----------SEVYIAVLQRsrlhaadwagr 395  human

Feature 1                                                                                      
1KFU_L     420 ----------------kmgedmHTIGFGIYEVpeelsgqtniHLSKNFFLtnrarersdTFINLREVLNRFK-LPPG--E 480  human
AAF48591   761 --------------------epKVIGFTMYTWdgey--mlseCLQKDFFKnhvs-ylnsDYGNTRHVSYHTH-LEAG--H 814  fruit fly
NP_493052  533 ----------------ykglelFLIGLLVYEMpgp-----neKVTPEMVKsqtpiadskLFKDSREANIRFT-VPLG--H 588  Caenorhabditis e...
NP_500081  538 ----------------hrgldmLQIGLSVYKMsgp-----neKVTAEMMKthapiastkLFVDYREAVVRFT-VPPG--Y 593  Caenorhabditis e...
13959310   413 ----------------mgrpdnYIIGFELFKVem------nrRFRLHHLYiqer-agtsTYIDTRTVFLSKY-LKKG--S 466  house mouse
2065242    416 ----------------egkgenLAIGFDIYKVee------nrQYRMHSLQhka---assIYINSRSVFLRTE-LPEG--R 467  house mouse
NP_502751  428 ----------------kkrepfVTIGMHVMKVen------nrQYRVHTAMhpi---aisDYASGRSVYLHLQsLPRG--R 480  Caenorhabditis e...
NP_175932 2057 --------------qsshdsqlFYIGLRILKTrg-------rRAAYNIFLhesv--ggtDYVNSREISCEMV-LDPDpkG 2112 thale cress
Q9HC96     396 aralvgdshtswspasipgkhyQAVGLHLWKVekr-----rvNLPRVLSMppva--gtaCHAYDREVHLRCE-LSPG--Y 465  human
NP_075573  396 aralvgdshtswspasipgkhyQAVGLHLWKVpeg-----grSQDAPPLLlqepllscvPHRYAQEVSRLCL-LPAG--T 467  human

Feature 1                                     
1KFU_L     481 YILVPSTFEPNKDGDFCIRVFSEKKADYQAV 511  human
AAF48591   815 YVLIPTTYEPAEEAHFTVRILGTGSFRLSCL 845  fruit fly
NP_493052  589 YVIVPSTYDPDQDGEFLLRIFTNVDFDKTHA 619  Caenorhabditis elegans
NP_500081  594 YVIVPCTFEPNHDAEFLLRTFSNVEFDKTDM 624  Caenorhabditis elegans
13959310   467 YVLVPTMFQHGRTSEFLLRIFSEVPVQLREL 497  house mouse
2065242    468 YVIIPTTFEPGHTGEFLLRVFTDVPSNCREL 498  house mouse
NP_502751  481 YLLIPTTFAPKEQTLFMLRVYSDEHIHFSPL 511  Caenorhabditis elegans
NP_175932 2113 YTIVPTTIHPGEEAPFVLSVFTKASIVLEAL 2143 thale cress
Q9HC96     466 YLAVPSTFLKDAPGEFLLRVFSTGRVSLSAI 496  human
NP_075573  468 YKVVPSTYLPDTEGAFTVTIATRIDRPSIHS 498  human

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