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CD180 CD180 molecule [ Homo sapiens (human) ]

Gene ID: 4064, updated on 17-Jun-2019

Summary

Official Symbol
CD180provided by HGNC
Official Full Name
CD180 moleculeprovided by HGNC
Primary source
HGNC:HGNC:6726
See related
Ensembl:ENSG00000134061 MIM:602226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LY64; Ly78; RP105
Summary
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 23.1), spleen (RPKM 12.8) and 10 other tissues See more
Orthologs

Genomic context

See CD180 in Genome Data Viewer
Location:
5q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (67179613..67196799, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (66477205..66492617, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase family member 4 Neighboring gene MAST4 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2367 Neighboring gene uncharacterized LOC101928819 Neighboring gene ribosomal protein L21 pseudogene 55

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat downregulates the expression of many proteins, including RP105, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126233, MGC126234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell proliferation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of lipopolysaccharide-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CD180 antigen
Names
lymphocyte antigen 64
lymphocyte antigen-64, radioprotective, 105kDa
radioprotective 105 kDa protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005582.3NP_005573.2  CD180 antigen precursor

    See identical proteins and their annotated locations for NP_005573.2

    Status: VALIDATED

    Source sequence(s)
    AC026445, AL544501, AL570708, AW512119, BC109069, BP344300
    Consensus CDS
    CCDS3992.1
    UniProtKB/Swiss-Prot
    Q99467
    Related
    ENSP00000256447.4, ENST00000256447.5
    Conserved Domains (4) summary
    cd00116
    Location:327541
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:276299
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:497555
    LRR_8; Leucine rich repeat
    cl15307
    Location:577626
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    67179613..67196799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248504.4XP_005248561.1  CD180 antigen isoform X1

    Conserved Domains (4) summary
    cd00116
    Location:314528
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:263286
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:484542
    LRR_8; Leucine rich repeat
    cl15307
    Location:564613
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
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