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Cd180 CD180 antigen [ Mus musculus (house mouse) ]

Gene ID: 17079, updated on 18-Apr-2024

Summary

Official Symbol
Cd180provided by MGI
Official Full Name
CD180 antigenprovided by MGI
Primary source
MGI:MGI:1194924
See related
Ensembl:ENSMUSG00000021624 AllianceGenome:MGI:1194924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly78; Ly-78; RP105; F630107B15
Summary
Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within B cell proliferation involved in immune response; cellular response to lipopolysaccharide; and positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CD180 (CD180 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 14.3), mammary gland adult (RPKM 3.5) and 8 other tissues See more
Orthologs
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Genomic context

Location:
13 D1; 13 54.92 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (102830055..102843139)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (102693547..102706631)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35504 Neighboring gene zinc finger and SCAN domain-containing protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35506 Neighboring gene STARR-positive B cell enhancer mm9_chr13:103468634-103468935 Neighboring gene STARR-positive B cell enhancer ABC_E7271 Neighboring gene STARR-positive B cell enhancer ABC_E1887 Neighboring gene STARR-positive B cell enhancer ABC_E7272 Neighboring gene STARR-positive B cell enhancer ABC_E10811 Neighboring gene STARR-seq mESC enhancer starr_35508 Neighboring gene predicted gene, 41046 Neighboring gene STARR-seq mESC enhancer starr_35509 Neighboring gene STARR-positive B cell enhancer ABC_E3097 Neighboring gene RIKEN cDNA 1700099I09 gene Neighboring gene microtubule associated serine/threonine kinase family member 4 Neighboring gene predicted gene 17160

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CD180 antigen
Names
lymphocyte antigen 78
radioprotective 105 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360519.1NP_001347448.1  CD180 antigen isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC239606
    Conserved Domains (4) summary
    TIGR00864
    Location:357431
    PCC; polycystin cation channel protein
    sd00033
    Location:131154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:228289
    LRR_8; Leucine rich repeat
    cl26793
    Location:81265
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  2. NM_008533.2NP_032559.2  CD180 antigen isoform 1 precursor

    See identical proteins and their annotated locations for NP_032559.2

    Status: VALIDATED

    Source sequence(s)
    AK089255, BY222876, BY529039
    Consensus CDS
    CCDS26741.1
    UniProtKB/Swiss-Prot
    Q62192, Q8C251
    UniProtKB/TrEMBL
    Q3U0U7
    Related
    ENSMUSP00000022124.4, ENSMUST00000022124.10
    Conserved Domains (4) summary
    smart00082
    Location:577626
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:345541
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:323346
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:420481
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    102830055..102843139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)