ZP2 zona pellucida glycoprotein 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ZP2provided by VGNC
Official Full Name: zona pellucida glycoprotein 2provided by VGNC
Primary source: VGNC:VGNC:48842
See related: Ensembl:ENSCAFG00845003418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: ZPA; Zp-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	6	NC_051810.1 (24381539..24393787)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	6	NC_006588.4 (25667939..25680181)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	6	NC_049227.1 (24463951..24476253)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	6	NC_049266.1 (24184937..24197176)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	6	NC_049747.1 (24078588..24090826)

Chromosome 6 - NC_051810.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of ZP2 and ZP3 genes is associated with the maturation stage of canine oocytes.
Title: Expression and cellular distribution of zona pellucida glycoproteins in canine oocytes before and after in vitro maturation.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables acrosin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables structural constituent of egg coat	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info	PubMed
involved_in prevention of polyspermy	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in egg coat	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: zona pellucida sperm-binding protein 2

Names: zona pellucida A protein; zona pellucida glycoprotein 2 (sperm receptor); zona pellucida glycoprotein ZP2; zona pellucida protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003304.2 → NP_001003304.2 zona pellucida sperm-binding protein 2 precursor

Status: VALIDATED

Source sequence(s)

D45069, U05779

UniProtKB/Swiss-Prot

P47983

UniProtKB/TrEMBL

A0A8C0L869, A0A8C0SP12, A0A8I3MQB5

Related

ENSCAFP00845004830.1, ENSCAFT00845006076.1

Conserved Domains (1) summary

smart00241
Location:369 → 634

ZP; Zona pellucida (ZP) domain