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ZP2 zona pellucida glycoprotein 2 [ Homo sapiens (human) ]

Gene ID: 7783, updated on 12-Sep-2021

Summary

Official Symbol
ZP2provided by HGNC
Official Full Name
zona pellucida glycoprotein 2provided by HGNC
Primary source
HGNC:HGNC:13188
See related
Ensembl:ENSG00000103310 MIM:182888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZPA; Zp-2; OOMD6
Summary
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZP2 in Genome Data Viewer
Location:
16p12.3-p12.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (21197450..21214510, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21208771..21225831, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 3 Neighboring gene Sharpr-MPRA regulatory region 1818 Neighboring gene lipid droplet assembly factor 1 Neighboring gene uncharacterized LOC105371123 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 4B Neighboring gene uncharacterized LOC105371125 Neighboring gene crystallin mu

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acrosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables coreceptor activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of egg coat IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables structural constituent of egg coat ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in prevention of polyspermy ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT involved_in regulation of acrosome reaction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in egg coat IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zona pellucida sperm-binding protein 2
Names
zona pellucida glycoprotein 2 (sperm receptor)
zona pellucida glycoprotein ZP2
zona pellucida protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376231.1NP_001363160.1  zona pellucida sperm-binding protein 2 isoform 2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AF001550, BC096305
    Consensus CDS
    CCDS73843.1
    Conserved Domains (1) summary
    pfam00100
    Location:372622
    Zona_pellucida; Zona pellucida-like domain
  2. NM_001376232.1NP_001363161.1  zona pellucida sperm-binding protein 2 isoform 1 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AF001550, AK313003
    Related
    ENSP00000458991.2, ENST00000574091.6
    Conserved Domains (1) summary
    pfam00100
    Location:372631
    Zona_pellucida; Zona pellucida-like domain
  3. NM_001376233.1NP_001363162.1  zona pellucida sperm-binding protein 2 isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AF001550
    Conserved Domains (1) summary
    pfam00100
    Location:372631
    Zona_pellucida; Zona pellucida-like domain
  4. NM_003460.2NP_003451.1  zona pellucida sperm-binding protein 2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_003451.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF001550, AK310454
    Consensus CDS
    CCDS10596.1
    UniProtKB/Swiss-Prot
    Q05996
    Related
    ENSP00000460971.1, ENST00000574002.1
    Conserved Domains (1) summary
    pfam00100
    Location:372631
    Zona_pellucida; Zona pellucida-like domain

RNA

  1. NR_164788.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF001550

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    21197450..21214510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    21141..38201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001290104.1: Suppressed sequence

    Description
    NM_001290104.1: This RefSeq was removed because currently there is support for the protein but not for the transcript.
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