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LRCH4 leucine rich repeats and calponin homology domain containing 4 [ Homo sapiens (human) ]

Gene ID: 4034, updated on 11-Jun-2021

Summary

Official Symbol
LRCH4provided by HGNC
Official Full Name
leucine rich repeats and calponin homology domain containing 4provided by HGNC
Primary source
HGNC:HGNC:6691
See related
Ensembl:ENSG00000077454
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRN; LRRN1; LRRN4; PP14183
Summary
This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 33.5), spleen (RPKM 31.2) and 25 other tissues See more
Orthologs
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Genomic context

See LRCH4 in Genome Data Viewer
Location:
7q22.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100574011..100586129, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100171634..100183752, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene insulin receptor substrate 3, pseudogene Neighboring gene Sin3A associated protein 25 Neighboring gene Sharpr-MPRA regulatory region 8670 Neighboring gene F-box protein 24 Neighboring gene PCOLCE antisense RNA 1 Neighboring gene procollagen C-endopeptidase enhancer Neighboring gene motile sperm domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40101, FLJ46315

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in PML body IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
leucine-rich repeat and calponin homology domain-containing protein 4
Names
leucine rich repeat neuronal 4
leucine-rich neuronal protein
leucine-rich repeats and calponin homology (CH) domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289934.2NP_001276863.1  leucine-rich repeat and calponin homology domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001276863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI491709, BC007634, BC018529, DC397219, DR422652
    UniProtKB/Swiss-Prot
    O75427
    Conserved Domains (5) summary
    cd00116
    Location:103245
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4669
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00307
    Location:537630
    CH; Calponin homology (CH) domain
    pfam12799
    Location:92131
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:138194
    LRR_8; Leucine rich repeat
  2. NM_002319.5NP_002310.2  leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_002310.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AI491709, BC007634, BC018529, DC397219, DR422652
    Consensus CDS
    CCDS34706.1
    UniProtKB/Swiss-Prot
    O75427
    Related
    ENSP00000309689.6, ENST00000310300.11
    Conserved Domains (5) summary
    cd00116
    Location:103245
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4669
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00307
    Location:537627
    CH; Calponin homology (CH) domain
    pfam12799
    Location:92131
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:138194
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100574011..100586129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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