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Conserved domains on  [gi|30181233|ref|NP_002310|]
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leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 536-643 4.29e-56

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409122  Cd Length: 109  Bit Score: 186.26  E-value: 4.29e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 536 DEKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMG 615
Cdd:cd21273   1 DEKELRAQLRKTLESRLKVTLPEDLAEALSNGAVLCQLANQLRPRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMG 80

                        90       100
                ....*....|....*....|....*....
gi 30181233 616 VPEADLCSPSDLL-QGTARGLRTALEAVK 643
Cdd:cd21273  81 VPEVDLCSPSDVLlQGPAAVLRTVLALLA 109
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-241 7.46e-42

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 157.40  E-value: 7.46e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIV 143
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 144 SNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPeELGDLP-LVRLDFSCNRVSRIPVS 222
Cdd:COG4886 190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPL 268

                       170
                ....*....|....*....
gi 30181233 223 fCRLRHLQVILLDSNPLQS 241
Cdd:COG4886 269 -ANLTNLKTLDLSNNQLTD 286
 
Name Accession Description Interval E-value
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 536-643 4.29e-56

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 186.26  E-value: 4.29e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 536 DEKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMG 615
Cdd:cd21273   1 DEKELRAQLRKTLESRLKVTLPEDLAEALSNGAVLCQLANQLRPRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMG 80

                        90       100
                ....*....|....*....|....*....
gi 30181233 616 VPEADLCSPSDLL-QGTARGLRTALEAVK 643
Cdd:cd21273  81 VPEVDLCSPSDVLlQGPAAVLRTVLALLA 109
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-241 7.46e-42

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 157.40  E-value: 7.46e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIV 143
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 144 SNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPeELGDLP-LVRLDFSCNRVSRIPVS 222
Cdd:COG4886 190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPL 268

                       170
                ....*....|....*....
gi 30181233 223 fCRLRHLQVILLDSNPLQS 241
Cdd:COG4886 269 -ANLTNLKTLDLSNNQLTD 286
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-220 5.51e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.59  E-value: 5.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   46 TLNLSNRRLKHFPRG--------AARSYDLSD--------ITQADLSRNRFPEVPEaacQLVS-LEGLSLYHNCLRCLNP 108
Cdd:PRK15370 203 TLILDNNELKSLPENlqgniktlYANSNQLTSipatlpdtIQEMELSINRITELPE---RLPSaLQSLDLFHNKISCLPE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  109 ALGNltALTYLNLSRNQLSLLPPYicqLPLRV--LIVSNNKLGALPPDIGTlgSLRQLDVSSNELQSLPSELCglSSLRD 186
Cdd:PRK15370 280 NLPE--ELRYLSVYDNSIRTLPAH---LPSGIthLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLP--PELQV 350

                        170       180       190
                 ....*....|....*....|....*....|....
gi 30181233  187 LNVRRNQLSTLPEELGDlPLVRLDFSCNRVSRIP 220
Cdd:PRK15370 351 LDVSKNQITVLPETLPP-TITTLDVSRNALTNLP 383
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 538-630 7.10e-14

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 67.73  E-value: 7.10e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233    538 KDLMTQLRQVLESRLQRPLpEDLAEALASGVILCQLANQLRPRSVPFIHVPspavPKLSALKARKNVESFLEACRKMGvP 617
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPV-TNFSSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLG-G 74

                           90
                   ....*....|...
gi 30181233    618 EADLCSPSDLLQG 630
Cdd:smart00033  75 KVVLFEPEDLVEG 87
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 537-627 1.54e-12

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 64.23  E-value: 1.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   537 EKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVpspavpKLSALKARKNVESFLE-ACRKMG 615
Cdd:pfam00307   4 EKELLRWINSHLAEYGPGVRVTNFTTDLRDGLALCALLNKLAPGLVDKKKL------NKSEFDKLENINLALDvAEKKLG 77

                          90
                  ....*....|..
gi 30181233   616 VPEADLcSPSDL 627
Cdd:pfam00307  78 VPKVLI-EPEDL 88
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-198 1.79e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 1.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  90 LVSLEGLSLYHNCLRCLNpALGNLTALTYLNLSRNQLsllPP--YICQLP---------LRVLIVSNNKLGALPPdIGTL 158
Cdd:cd21340  67 LVNLKKLYLGGNRISVVE-GLENLTNLEELHIENQRL---PPgeKLTFDPrslaalsnsLRVLNISGNNIDSLEP-LAPL 141

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 30181233 159 GSLRQLDVSSNELQSLpSELC----GLSSLRDLNVRRNQLSTLP 198
Cdd:cd21340 142 RNLEQLDASNNQISDL-EELLdllsSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
74-126 1.96e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.96e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 30181233    74 DLSRNRFPEV-PEAACQLVSLEGLSLYHNCLRCLNP-ALGNLTALTYLNLSRNQL 126
Cdd:pfam13855   7 DLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
SCP1 COG5199
Calponin [Cytoskeleton];
529-643 1.77e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 45.68  E-value: 1.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 529 RRYPQVPD-EKDLMTQLRQVLESRLQRPLpeDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVpklsalkARKNVESF 607
Cdd:COG5199   6 NRCPGMDKqQKEVTLWIETVLGEKFEPPG--DLLSLLKDGVRLCRILNEASPLDIKYKESKMPFV-------QMENISSF 76

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30181233 608 LEACRKMGVPEADLCSPSDLLQgtARGLRTALEAVK 643
Cdd:COG5199  77 INGLKKLRVPEYELFQTNDLFE--AKDLRQVVICLY 110
 
Name Accession Description Interval E-value
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 536-643 4.29e-56

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 186.26  E-value: 4.29e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 536 DEKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMG 615
Cdd:cd21273   1 DEKELRAQLRKTLESRLKVTLPEDLAEALSNGAVLCQLANQLRPRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMG 80

                        90       100
                ....*....|....*....|....*....
gi 30181233 616 VPEADLCSPSDLL-QGTARGLRTALEAVK 643
Cdd:cd21273  81 VPEVDLCSPSDVLlQGPAAVLRTVLALLA 109
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 539-643 2.63e-50

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 170.56  E-value: 2.63e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 539 DLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPE 618
Cdd:cd21205   1 EQIEQLRKSIESRLKVTLPDDLGEALMDGVVLCHLANHVRPRSVPSIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE 80

                        90       100
                ....*....|....*....|....*..
gi 30181233 619 ADLCSPSDLLQ--GTARGLRTALEAVK 643
Cdd:cd21205  81 ERLCSPGDILEekGLVRVAVTVQALLQ 107
CH_LRCH1 cd21270
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 536-647 2.46e-42

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1; Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409119  Cd Length: 112  Bit Score: 148.85  E-value: 2.46e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 536 DEKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMG 615
Cdd:cd21270   1 EERELTEQLRENIETRLKVSLPEDLGAALMDGVVLCHLVNHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKIG 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 30181233 616 VPEADLCSPSDLLQGTARGLRTALEAVKRVGG 647
Cdd:cd21270  81 VPEADLCSPYDILQLNLRGIRKTVETLLALGE 112
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-241 7.46e-42

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 157.40  E-value: 7.46e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIV 143
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 144 SNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPeELGDLP-LVRLDFSCNRVSRIPVS 222
Cdd:COG4886 190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPL 268

                       170
                ....*....|....*....
gi 30181233 223 fCRLRHLQVILLDSNPLQS 241
Cdd:COG4886 269 -ANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-243 9.36e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 145.46  E-value: 9.36e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  44 TGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNclrclnPALGNLTALTYLNLSR 123
Cdd:COG4886  49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSG 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 124 NQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELG 202
Cdd:COG4886 123 NQLTDLPEELANLTnLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 30181233 203 DLP-LVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPP 243
Cdd:COG4886 203 NLTnLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-240 1.91e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 144.69  E-value: 1.91e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  33 SAERALEEAVATGTLNLSNRRLKHFPRGAARsydLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGN 112
Cdd:COG4886 104 SGNEELSNLTNLESLDLSGNQLTDLPEELAN---LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGN 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 113 LTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPsELCGLSSLRDLNVRR 191
Cdd:COG4886 181 LTNLKELDLSNNQITDLPEPLGNLTnLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSN 259

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 30181233 192 NQLSTLPEELGDLPLVRLDFSCNRVSRIpvsfcRLRHLQVILLDSNPLQ 240
Cdd:COG4886 260 NQLTDLPPLANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLL 303
CH_LRCH2 cd21271
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 536-635 3.34e-36

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2; Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409120  Cd Length: 111  Bit Score: 131.59  E-value: 3.34e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 536 DEKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMG 615
Cdd:cd21271   2 EELELIEQLRENIESRLKVILPEDLGAALMDGVVLCHLANHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKLG 81

                        90       100
                ....*....|....*....|
gi 30181233 616 VPEADLCSPSDLLQgtARGL 635
Cdd:cd21271  82 VPEDKLCLPHHILE--EKGL 99
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 540-635 5.81e-35

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409121  Cd Length: 109  Bit Score: 128.18  E-value: 5.81e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 540 LMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEA 619
Cdd:cd21272   2 LIEQLRKNIESRLKVSLPSDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQE 81

                        90
                ....*....|....*.
gi 30181233 620 DLCSPSDLLQgtARGL 635
Cdd:cd21272  82 QLCLPLHILE--EKGL 95
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 537-630 6.78e-22

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 90.86  E-value: 6.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 537 EKDLMTQLRQVLESRLQRPlPEDLAEALASGVILCQLANQLRPRSVPFIHVPSpavpkLSALKARKNVESFLEACRKMGV 616
Cdd:cd00014   1 EEELLKWINEVLGEELPVS-ITDLFESLRDGVLLCKLINKLSPGSIPKINKKP-----KSPFKKRENINLFLNACKKLGL 74

                        90
                ....*....|....
gi 30181233 617 PEADLCSPSDLLQG 630
Cdd:cd00014  75 PELDLFEPEDLYEK 88
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-210 1.15e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 1.15e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  46 TLNLSNRRLKHFPRGAARsydLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQ 125
Cdd:COG4886 163 SLDLSNNQLTDLPEELGN---LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 126 LSLLPpYICQLP-LRVLIVSNNKLGALPPdIGTLGSLRQLDVSSNELQSLP-SELCGLSSLRDLNVRRNQLSTLPEELGD 203
Cdd:COG4886 240 LTDLP-ELGNLTnLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILL 317


                ....*..
gi 30181233 204 LPLVRLD 210
Cdd:COG4886 318 LLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-244 9.98e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 9.98e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  64 SYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLI 142
Cdd:COG4886  23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTnLTELD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 143 VSNNKlgalppDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPV 221
Cdd:COG4886 103 LSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTnLKSLDLSNNQLTDLPE 176

                       170       180
                ....*....|....*....|...
gi 30181233 222 SFCRLRHLQVILLDSNPLQSPPA 244
Cdd:COG4886 177 ELGNLTNLKELDLSNNQITDLPE 199
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-220 5.51e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.59  E-value: 5.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   46 TLNLSNRRLKHFPRG--------AARSYDLSD--------ITQADLSRNRFPEVPEaacQLVS-LEGLSLYHNCLRCLNP 108
Cdd:PRK15370 203 TLILDNNELKSLPENlqgniktlYANSNQLTSipatlpdtIQEMELSINRITELPE---RLPSaLQSLDLFHNKISCLPE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  109 ALGNltALTYLNLSRNQLSLLPPYicqLPLRV--LIVSNNKLGALPPDIGTlgSLRQLDVSSNELQSLPSELCglSSLRD 186
Cdd:PRK15370 280 NLPE--ELRYLSVYDNSIRTLPAH---LPSGIthLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLP--PELQV 350

                        170       180       190
                 ....*....|....*....|....*....|....
gi 30181233  187 LNVRRNQLSTLPEELGDlPLVRLDFSCNRVSRIP 220
Cdd:PRK15370 351 LDVSKNQITVLPETLPP-TITTLDVSRNALTNLP 383
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 538-630 7.10e-14

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 67.73  E-value: 7.10e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233    538 KDLMTQLRQVLESRLQRPLpEDLAEALASGVILCQLANQLRPRSVPFIHVPspavPKLSALKARKNVESFLEACRKMGvP 617
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPV-TNFSSDLKDGVALCALLNSLSPGLVDKKKVA----ASLSRFKKIENINLALSFAEKLG-G 74

                           90
                   ....*....|...
gi 30181233    618 EADLCSPSDLLQG 630
Cdd:smart00033  75 KVVLFEPEDLVEG 87
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 548-627 4.38e-13

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 65.79  E-value: 4.38e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 548 LESRLQRPLPE--DLAEALASGVILCQLANQLRPRSVPFIHVpspavpKLSALKARKNVESFLEACRKMGVPEADLCSPS 625
Cdd:cd21207  14 IEAVTGEKLDDgkDYEDVLKDGVILCKLINILKPGSVKKINT------SKMAFKLMENIENFLTACKGYGVPKTDLFQTV 87


                ..
gi 30181233 626 DL 627
Cdd:cd21207  88 DL 89
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
 559-631 5.52e-13

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 65.74  E-value: 5.52e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30181233 559 DLAEALASGVILCQLANQLRPRSVPFIHVPSPavPKLSALKARKNVESFLEACRKM-GVPEADLCSPSDLLQGT 631
Cdd:cd21201  31 DLAQALRDGVLLCQLLNRLSPGSVDDREINLR--PQMSQFLCLKNIRTFLQACRTVfGLRSADLFEPEDLYDVT 102
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-259 1.14e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   47 LNLSNRRLK-HFPRGAarsydLSDITQADLSRNRFP-EVPEAACQLVSLEGLSLYHNCLRCLNPA-LGNLTALTYLNLSR 123
Cdd:PLN00113 123 LNLSNNNFTgSIPRGS-----IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNsLTNLTSLEFLTLAS 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  124 NQLS-LLPPYICQLPLRVLIV--SNNKLGALPPDIGTLGSLRQLDVSSNELQ-SLPSELCGLSSLRDLNVRRNQLS-TLP 198
Cdd:PLN00113 198 NQLVgQIPRELGQMKSLKWIYlgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIP 277

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30181233  199 EELGDLP-LVRLDFSCNRVS-RIPVSFCRLRHLQVILLDSNPLQSP-PAQVCLKGKLHIFKYLS 259
Cdd:PLN00113 278 PSIFSLQkLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKiPVALTSLPRLQVLQLWS 341
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 537-627 1.54e-12

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 64.23  E-value: 1.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   537 EKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVpspavpKLSALKARKNVESFLE-ACRKMG 615
Cdd:pfam00307   4 EKELLRWINSHLAEYGPGVRVTNFTTDLRDGLALCALLNKLAPGLVDKKKL------NKSEFDKLENINLALDvAEKKLG 77

                          90
                  ....*....|..
gi 30181233   616 VPEADLcSPSDL 627
Cdd:pfam00307  78 VPKVLI-EPEDL 88
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-198 1.79e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 1.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  90 LVSLEGLSLYHNCLRCLNpALGNLTALTYLNLSRNQLsllPP--YICQLP---------LRVLIVSNNKLGALPPdIGTL 158
Cdd:cd21340  67 LVNLKKLYLGGNRISVVE-GLENLTNLEELHIENQRL---PPgeKLTFDPrslaalsnsLRVLNISGNNIDSLEP-LAPL 141

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 30181233 159 GSLRQLDVSSNELQSLpSELC----GLSSLRDLNVRRNQLSTLP 198
Cdd:cd21340 142 RNLEQLDASNNQISDL-EELLdllsSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-244 8.30e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.72  E-value: 8.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   82 EVPEAACQLVSLEGLSL-YHNCLRCLNPALGNLTALTYLNLSRNQLS-LLPPYICQLP-LRVLIVSNNKL-GALPPDIGT 157
Cdd:PLN00113 227 EIPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQkLISLDLSDNSLsGEIPELVIQ 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  158 LGSLRQLDVSSNELQ-SLPSELCGLSSLRDLNVRRNQLS-TLPEELGDL-PLVRLDFSCNRVS-RIPVSFCRLRHLQVIL 233
Cdd:PLN00113 307 LQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHnNLTVLDLSTNNLTgEIPEGLCSSGNLFKLI 386

                        170
                 ....*....|...
gi 30181233  234 LDSNPLQS--PPA 244
Cdd:PLN00113 387 LFSNSLEGeiPKS 399
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-243 9.35e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.19  E-value: 9.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  67 LSDITQADLSRNRFPEVPE-AACQlvSLEGLSLYHNCLRCLnPALGNLTALTYLNLSRNQLSLLPPyICQLP-LRVLIVS 144
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNlSLCK--NLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVnLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 145 NNK------LGALPpdigtlgSLRQLDVSSnelQSLPSE---------LCGLS-SLRDLNVRRNQLSTLpEELGDLP-LV 207
Cdd:cd21340  77 GNRisvvegLENLT-------NLEELHIEN---QRLPPGekltfdprsLAALSnSLRVLNISGNNIDSL-EPLAPLRnLE 145

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 30181233 208 RLDFSCNRVSRIP---VSFCRLRHLQVILLDSNPLQSPP 243
Cdd:cd21340 146 QLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 557-654 3.43e-11

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 60.82  E-value: 3.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 557 PEDLAEALASGVILCQLANQLRPRSVPFIHVPSpavpklSALKARKNVESFLEACRKMGVPEADLCSPSDLLQGTARGLR 636
Cdd:cd21208  19 SDDFRESLEDGILLCELINAIKPGSIKKINRLP------TPIAGLDNLNLFLKACEDLGLKDSQLFDPTDLQDLSNRRIA 92

                        90       100
                ....*....|....*....|.
gi 30181233 637 TA---LEAVKRVGGKALPPLW 654
Cdd:cd21208  93 THvrkKEDERRLKNVAITLYW 113
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 545-630 6.68e-11

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 59.30  E-value: 6.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 545 RQVLESRLQRPLPE-DLAEALASGVILCQLANQLRPRSVPFIH-VPSPAVpklsalkARKNVESFLEACRKMGVPEADLC 622
Cdd:cd21210   6 REWIEEVLGEKLAQgDLLDALKDGVVLCKLANRILPADIRKYKeSKMPFV-------QMENISAFLNAARKLGVPENDLF 78


                ....*...
gi 30181233 623 SPSDLLQG 630
Cdd:cd21210  79 QTVDLFER 86
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
 558-630 2.78e-10

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 58.19  E-value: 2.78e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30181233 558 EDLAEALASGVILCQLANQLRPRSVPFI--HVPSPAVPKLSALKARKNVESFLEACRKMGVPeadLCSPSDLLQG 630
Cdd:cd21203  24 EEFRLCLRDGVVLCKLLNKLQPGAVPKVveSPDDPDGAAGSAFQYFENVRNFLVAIEEMGLP---TFEASDLEQG 95
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 544-648 4.97e-10

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 57.66  E-value: 4.97e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 544 LRQVLESRLQrplPEDLAEALASGVILCQLAN--QLRPRSVPFIHVPSPAVP----------KLSALKARKNVESFLEAC 611
Cdd:cd21204  15 LNDLLGDDLT---PDNFLDELRNGVVLCQLAQkiQEAAEKAREAGKKNGPPPsyklkcnenaKPGSFFARDNVANFLRWC 91

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 30181233 612 RKMGVPEADLCSPSDLLQGTA-RGLRTALEAVKRVGGK 648
Cdd:cd21204  92 RKLGVDEVLLFESEDLVLHKNpRQVLLCLLELARIAAR 129
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 112-229 1.88e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 1.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  112 NLTALTYLNLSRNQLS-LLPPYICQLPLRVLIVSNNKL-GALPPDIGTLGSLRQLDVSSNELQS-LPSELCGLSSLRDLN 188
Cdd:PLN00113 450 DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLD 529

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 30181233  189 VRRNQLS-TLPEELGDLP-LVRLDFSCNRVS-RIPVSFCRLRHL 229
Cdd:PLN00113 530 LSHNQLSgQIPASFSEMPvLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-239 4.85e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 4.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   76 SRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPA-LGNLTALTYLNLSRNQLS-LLPPYICQLP--LRVLIVSNNKLGAL 151
Cdd:PLN00113 317 SNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKnLGKHNNLTVLDLSTNNLTgEIPEGLCSSGnlFKLILFSNSLEGEI 396

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  152 PPDIGTLGSLRQ------------------------LDVSSNELQ-SLPSELCGLSSLRDLNVRRNQLS-TLPEELGDLP 205
Cdd:PLN00113 397 PKSLGACRSLRRvrlqdnsfsgelpseftklplvyfLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKR 476

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 30181233  206 LVRLDFSCNRVS-RIPVSFCRLRHLQVILLDSNPL 239
Cdd:PLN00113 477 LENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKL 511
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-242 1.66e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   68 SDITQADLS-RNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPA--LGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVS 144
Cdd:PLN00113  69 SRVVSIDLSgKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDdiFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  145 NNKL-GALPPDIGTLGSLRQLDVSSNELQS-LPSELCGLSSLRDLNVRRNQLS-TLPEELGDL----------------- 204
Cdd:PLN00113 149 NNMLsGEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMkslkwiylgynnlsgei 228

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 30181233  205 --------PLVRLDFSCNRVS-RIPVSFCRLRHLQVILLDSNPLQSP 242
Cdd:PLN00113 229 pyeiggltSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGP 275
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
 543-631 4.52e-08

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 51.41  E-value: 4.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 543 QLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLsalkarKNVESFLEACRKMGVPEADLC 622
Cdd:cd21282   7 ELRVWIEGVTGRRIGDNFMDGLKDGVILCELINKLQPGSVRKINESTQNWHKL------ENIGNFIKAIMHYGVKPHDIF 80


                ....*....
gi 30181233 623 SPSDLLQGT 631
Cdd:cd21282  81 EANDLFENT 89
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
67-245 1.03e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.17  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   67 LSDITQADLSRNRFPEVPEAACQLVSleglslYHNCLRCLnPALGnlTALTYLNLSRNQLSLLPpyicQLP--LRVLIVS 144
Cdd:PRK15387 304 LQELSVSDNQLASLPALPSELCKLWA------YNNQLTSL-PTLP--SGLQELSVSDNQLASLP----TLPseLYKLWAY 370

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  145 NNKLGALPpdiGTLGSLRQLDVSSNELQSLPselCGLSSLRDLNVRRNQLSTLPEelgdLP--LVRLDFSCNRVSRIPVS 222
Cdd:PRK15387 371 NNRLTSLP---ALPSGLKELIVSGNRLTSLP---VLPSELKELMVSGNRLTSLPM----LPsgLLSLSVYRNQLTRLPES 440

                        170       180
                 ....*....|....*....|...
gi 30181233  223 FCRLRHLQVILLDSNPLQSPPAQ 245
Cdd:PRK15387 441 LIHLSSETTVNLEGNPLSERTLQ 463
PLN03150 PLN03150
hypothetical protein; Provisional
 129-211 1.12e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  129 LPPYICQLP-LRVLIVSNNKL-GALPPDIGTLGSLRQLDVSSNELQ-SLPSELCGLSSLRDLNVRRNQLS-TLPEELGDL 204
Cdd:PLN03150 434 IPNDISKLRhLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALGGR 513


                 ....*..
gi 30181233  205 PLVRLDF 211
Cdd:PLN03150 514 LLHRASF 520
CH_VAV1 cd21262
calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the ...
 559-630 1.57e-07

calponin homology (CH) domain found in VAV1 protein; VAV1 is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV1 protein.


Pssm-ID: 409111  Cd Length: 120  Bit Score: 50.33  E-value: 1.57e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30181233 559 DLAEALASGVILCQLANQLRPRSVPFIHVpsPAVPKLSALKARKNVESFLEAC-RKMGVPEADLCSPSDLLQG 630
Cdd:cd21262  31 DLAQALRDGVLLCQLLNNLLPHAVNLREI--NLRPQMSQFLCLKNIRTFLSTCcEKFGLRKSELFEAFDLFDV 101
CH_VAV3 cd21264
calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously ...
 559-628 4.16e-07

calponin homology (CH) domain found in VAV3 protein and similar proteins; VAV3 is ubiquitously expressed and functions as a phosphorylation-dependent guanine nucleotide exchange factor (GEF) for RhoA, RhoG, and Rac1. Its function has been implicated in the hematopoietic, bone, cerebellar, and cardiovascular systems. VAV3 is essential in axon guidance in neurons that control blood pressure and respiration. It is overexpressed in prostate cancer cells and it plays a role in regulating androgen receptor transcriptional activity. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV3 protein.


Pssm-ID: 409113  Cd Length: 117  Bit Score: 49.19  E-value: 4.16e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30181233 559 DLAEALASGVILCQLANQLRPRSVPFIHVpsPAVPKLSALKARKNVESFLEA-CRKMGVPEADLCSPSDLL 628
Cdd:cd21264  31 DLAQTLRDGVLLCQLLNNLRPHSINLKEI--NLRPQMSQFLCLKNIRTFLSAcCETFGMRKSELFEAFDLF 99
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-246 5.96e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.78  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   83 VPEAACQLVsleglsLYHNCLRCLNPAL-GNLTALTylnLSRNQLSLLPPyicQLP--LRVLIVSNNKLGALPPDIGTlg 159
Cdd:PRK15370 197 IPEQITTLI------LDNNELKSLPENLqGNIKTLY---ANSNQLTSIPA---TLPdtIQEMELSINRITELPERLPS-- 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  160 SLRQLDVSSNELQSLPSELCglSSLRDLNVRRNQLSTLPEELGDlPLVRLDFSCNRVSRIPVSFCrlRHLQVILLDSNPL 239
Cdd:PRK15370 263 ALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLKTLEAGENAL 337


                 ....*..
gi 30181233  240 QSPPAQV 246
Cdd:PRK15370 338 TSLPASL 344
CH_CNN cd21211
calponin homology (CH) domain found in the calponin family; Calponin is an actin ...
 543-631 6.18e-07

calponin homology (CH) domain found in the calponin family; Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. There are three calponin isoforms, calponin-1, -2, -3. All of them are actin-binding proteins with functions in inhibiting actin-activated myosin ATPase and stabilizing the actin cytoskeleton. Calponin-1 is specifically expressed in smooth muscle cells and plays a role in fine-tuning smooth muscle contractility. Calponin-2 is expressed in both smooth muscle and non-muscle cells and regulates multiple actin cytoskeleton-based functions. Calponin-3 is expressed in the brain and participates in actin cytoskeleton-based activities in embryonic development and myogenesis. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409060 [Multi-domain]  Cd Length: 108  Bit Score: 48.46  E-value: 6.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 543 QLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLsalkarKNVESFLEACRKMGVPEADLC 622
Cdd:cd21211   7 ELRTWIEGVTGLSIGPNFQKGLKDGIILCELINKLQPGSVKKINESMQNWHQL------ENIGNFIKAIVSYGMKPHDIF 80


                ....*....
gi 30181233 623 SPSDLLQGT 631
Cdd:cd21211  81 EANDLFENG 89
CH_CNN2 cd21283
calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral ...
 542-642 9.99e-07

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409132 [Multi-domain]  Cd Length: 109  Bit Score: 47.62  E-value: 9.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 542 TQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLsalkarKNVESFLEACRKMGVPEADL 621
Cdd:cd21283   6 AELRTWIEGLTGRSIGPDFQKGLKDGVILCELMNKLQPGSVPKINRSMQNWHQL------ENLSNFIKAMVSYGMKPVDL 79

                        90       100
                ....*....|....*....|..
gi 30181233 622 CSPSDLLQ-GTARGLRTALEAV 642
Cdd:cd21283  80 FEANDLFEsGNMTQVQVSLLAL 101
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-176 1.81e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   47 LNLSNRRlkhFPRGAARSYDLSDITQADLSRNRFPE-VPEAACQLVSLEGLSLYHNCLRCLNPA-LGNLTALTYLNLSRN 124
Cdd:PLN00113 457 LSLARNK---FFGGLPDSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDeLSSCKKLVSLDLSHN 533

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 30181233  125 QLS-LLPPYICQLP-LRVLIVSNNKL-GALPPDIGTLGSLRQLDVSSNELQ-SLPS 176
Cdd:PLN00113 534 QLSgQIPASFSEMPvLSQLDLSQNQLsGEIPKNLGNVESLVQVNISHNHLHgSLPS 589
LRR_8 pfam13855
Leucine rich repeat;
74-126 1.96e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.96e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 30181233    74 DLSRNRFPEV-PEAACQLVSLEGLSLYHNCLRCLNP-ALGNLTALTYLNLSRNQL 126
Cdd:pfam13855   7 DLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
CH_LMO7 cd21277
calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 ...
 558-627 2.91e-06

calponin homology (CH) domain found in LIM domain only protein 7; LIM domain only protein 7 (LMO-7), also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409126 [Multi-domain]  Cd Length: 116  Bit Score: 46.75  E-value: 2.91e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 558 EDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSalkarkNVESFLEACRKMGVPEADLCSPSDL 627
Cdd:cd21277  20 KDFRSALENGVLLCDLINKIKPGIIKKINRLSTPIAGLD------NINVFLKACEKLGLKEAQLFHPGDL 83
CH_VAV2 cd21263
calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely ...
 559-645 3.86e-06

calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV2 protein.


Pssm-ID: 409112  Cd Length: 119  Bit Score: 46.49  E-value: 3.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 559 DLAEALASGVILCQLANQLRPRSVPFIHVPSPavPKLSALKARKNVESFLEACR-KMGVPEADLCSPSDLLQgtARGLRT 637
Cdd:cd21263  31 DLAQALRDGVLLCQLLHNLSPGSIDLKDINFR--PQMSQFLCLKNIRTFLKVCHdKFGLRNSELFDPFDLFD--VRDFGK 106


                ....*...
gi 30181233 638 ALEAVKRV 645
Cdd:cd21263 107 VISALSRL 114
CH_PIX cd21202
calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak ...
 560-647 7.25e-06

calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak Interactive eXchange factor (PIX) proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX family, alpha-PIX and beta-PIX. Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6), is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7), plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Both alpha-PIX and beta-PIX contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409051 [Multi-domain]  Cd Length: 114  Bit Score: 45.60  E-value: 7.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 560 LAEALASGVILCQLANQLRPRSVPFIHvPSPavpkLSALKARKNVESFLEACRKMGVPEADLCSPSDLLQGT--ARGLRT 637
Cdd:cd21202  30 LSESLKNGVVLCRLVNRLKPGTVEKIY-DEP----TTEEECLYNFESFLKACQELGILAEEIFDPNDLYSGGnfQKVLST 104

                        90
                ....*....|
gi 30181233 638 aLEAVKRVGG 647
Cdd:cd21202 105 -LERLEKVAG 113
LRR_8 pfam13855
Leucine rich repeat;
182-239 9.79e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 9.79e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30181233   182 SSLRDLNVRRNQLSTLPEE-LGDLP-LVRLDFSCNRVSRI-PVSFCRLRHLQVILLDSNPL 239
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSnLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
SCP1 COG5199
Calponin [Cytoskeleton];
529-643 1.77e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 45.68  E-value: 1.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 529 RRYPQVPD-EKDLMTQLRQVLESRLQRPLpeDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVpklsalkARKNVESF 607
Cdd:COG5199   6 NRCPGMDKqQKEVTLWIETVLGEKFEPPG--DLLSLLKDGVRLCRILNEASPLDIKYKESKMPFV-------QMENISSF 76

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30181233 608 LEACRKMGVPEADLCSPSDLLQgtARGLRTALEAVK 643
Cdd:COG5199  77 INGLKKLRVPEYELFQTNDLFE--AKDLRQVVICLY 110
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 92-214 2.37e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.48  E-value: 2.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  92 SLEGLSLYHNCLRC-----LNPALGNLTALTYLNLSRNQLS------LLPPYICQLPLRVLIVSNNKLG-----ALPPDI 155
Cdd:COG5238 265 TVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGdegaiaLAEGLQGNKTLHTLNLAYNGIGaqgaiALAKAL 344

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30181233 156 GTLGSLRQLDVSSNEL-----QSLPSELCGLSSLRDLNVRRNQLSTL-PEELGDL----PLVRLDFSCN 214
Cdd:COG5238 345 QENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIGKQgAEALIDAlqtnRLHTLILDGN 413
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 545-618 3.98e-05

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 43.37  E-value: 3.98e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30181233 545 RQVLESRLQRPLP--EDLAEALASGVILCQLANQLRPRSVPFIHVPSpavpklSALKAR--KNVESFLEACRKMGVPE 618
Cdd:cd21206  14 KQWIEACLNEELPptTEFEEELRNGVVLAKLANKFAPKLVPLKKIYD------VGLQFRhtDNINHFLRALKKIGLPK 85
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
117-243 4.24e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 4.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  117 TYLNLSRNQLSLLPPYIcqlplrvlivsnnklgalPPDIGTLgslrQLDvsSNELQSLPSELCGlsSLRDLNVRRNQLST 196
Cdd:PRK15370 181 TELRLKILGLTTIPACI------------------PEQITTL----ILD--NNELKSLPENLQG--NIKTLYANSNQLTS 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 30181233  197 LPEELGDlPLVRLDFSCNRVSRIPVsfcRL-RHLQVILLDSNPLQSPP 243
Cdd:PRK15370 235 IPATLPD-TIQEMELSINRITELPE---RLpSALQSLDLFHNKISCLP 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-244 4.48e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 4.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  87 ACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDV 166
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30181233 167 SSNELQSLPSELCGLSSLRDLNVRRNqlstlpEELGDLP-LVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTnLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153
CH_TAGLN3 cd21281
calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal ...
 548-630 5.50e-05

calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409130 [Multi-domain]  Cd Length: 119  Bit Score: 43.03  E-value: 5.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 548 LESRL------------QRPLP--EDLAEALASGVILCQLANQLRPRSvpfiHVPSPAVPKLS-ALKARKNVESFLEACR 612
Cdd:cd21281   4 LESRLvdwiiiqcggdiERPQPgrQNFQKWLMDGTILCRLINSLYPPG----KEPIKKISETKmAFKQMEKISQFLQAAE 79

                        90
                ....*....|....*...
gi 30181233 613 KMGVPEADLCSPSDLLQG 630
Cdd:cd21281  80 AYGVITTDIFQTVDLWEG 97
CH_LIMCH1 cd21278
calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1; ...
 558-633 5.60e-05

calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1; LIM and calponin homology domains-containing protein 1 (LIMCH1) acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. LIMCH1 contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409127 [Multi-domain]  Cd Length: 118  Bit Score: 42.93  E-value: 5.60e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30181233 558 EDLAEALASGVILCQLANQLRPRSVPFIH-VPSPavpklsaLKARKNVESFLEACRKMGVPEADLCSPSDLLQGTAR 633
Cdd:cd21278  20 KDFRSGLENGILLCELLNAIKPGLVKKINrLPTP-------IAGLDNITLFLRGCKELGLKESQLFDPGDLQDTSNR 89
CH_CNN3 cd21284
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ...
 532-642 7.41e-05

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409133 [Multi-domain]  Cd Length: 111  Bit Score: 42.58  E-value: 7.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 532 PQVPDEkdlmtqLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLsalkarKNVESFLEAC 611
Cdd:cd21284   4 PQKEEE------LRNWIEEVTGMSIGENFQKGLKDGVILCELINKLQPGSIRKINESKLNWHQL------ENIGNFIKAI 71

                        90       100       110
                ....*....|....*....|....*....|..
gi 30181233 612 RKMGVPEADLCSPSDLLQ-GTARGLRTALEAV 642
Cdd:cd21284  72 QAYGMKPHDIFEANDLFEnGNMTQVQTTLLAL 103
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 557-630 1.58e-04

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 42.30  E-value: 1.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 557 PEDLAEALASGVILCQLAN----------QLRPRSVPFIHVP-------SPAVPKLSaLKARKNVESFLEACRK-MGVPE 618
Cdd:cd21268  30 ADNFFEKLETGVLLCKHANnvtraarefqAQHPERASPLKLPprevifyRPSAKPGS-FQARDNVSNFINWCRQlLGIPE 108

                        90
                ....*....|..
gi 30181233 619 ADLCSPSDLLQG 630
Cdd:cd21268 109 VLLFETDDLVLR 120
CH_TAGLN2 cd21280
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ...
 550-630 1.67e-04

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409129 [Multi-domain]  Cd Length: 137  Bit Score: 42.17  E-value: 1.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 550 SRLQRPLP--EDLAEALASGVILCQLANQLRPRSV-PFIHVPSPAVpklsALKARKNVESFLEACRKMGVPEADLCSPSD 626
Cdd:cd21280  23 KQVGRPQPgrENFQNWLKDGTVLCHLINSLYPKGQaPVKKIQASTM----AFKQMEQISQFLQAAERYGINTTDIFQTVD 98


                ....
gi 30181233 627 LLQG 630
Cdd:cd21280  99 LWEG 102
CH_TAGLN cd21279
calponin homology (CH) domain found in transgelin; Transgelin, also called 22 kDa ...
 564-630 2.09e-04

calponin homology (CH) domain found in transgelin; Transgelin, also called 22 kDa actin-binding protein, protein WS3-10, or smooth muscle protein 22-alpha (SM22-alpha), acts as an actin cross-linking/gelling protein that may be involved in calcium interactions and in regulating contractile properties of the cell. It may also contribute to replicative senescence. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409128 [Multi-domain]  Cd Length: 121  Bit Score: 41.53  E-value: 2.09e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30181233 564 LASGVILCQLANQLRPRSVPFIHVPSPavPKLSALKARKNVESFLEACRKMGVPEADLCSPSDLLQG 630
Cdd:cd21279  34 LKNGVVLSKLVNSLYPDGSKPVKIPDN--PPSMVFKQMEQVAQFLKAAEDYGVVKTDMFQTVDLYEG 98
LRR_8 pfam13855
Leucine rich repeat;
116-171 5.14e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.14e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 30181233   116 LTYLNLSRNQLSLLPPYICQ-LP-LRVLIVSNNKLGALPPD-IGTLGSLRQLDVSSNEL 171
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSnLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
70-243 5.33e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 5.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   70 ITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYlnlSRNQLSLLPPYICQLplrvLIVSNN--K 147
Cdd:PRK15387 224 ITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSN---PLTHLPALPSGLCKL----WIFGNQltS 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233  148 LGALPPdigtlgSLRQLDVSSNELQS---LPSELCGL--------------SSLRDLNVRRNQLSTLP------------ 198
Cdd:PRK15387 297 LPVLPP------GLQELSVSDNQLASlpaLPSELCKLwaynnqltslptlpSGLQELSVSDNQLASLPtlpselyklway 370

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 30181233  199 -EELGDLP-----LVRLDFSCNRVSRIPVSFCRLRHLQVillDSNPLQSPP 243
Cdd:PRK15387 371 nNRLTSLPalpsgLKELIVSGNRLTSLPVLPSELKELMV---SGNRLTSLP 418
LRR_8 pfam13855
Leucine rich repeat;
92-148 6.64e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 6.64e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233    92 SLEGLSLYHNCLRCLNP-ALGNLTALTYLNLSRNQLSLLPPY-ICQLP-LRVLIVSNNKL 148
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPsLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 103-245 8.33e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 8.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 103 LRCLNPALGNLTALTYLNLSRNQLSLLPPYICQL-----PLRVLIVSNNKLG--ALPPDIGTLGS----LRQLDVSSNEL 171
Cdd:cd00116  70 LQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESllrssSLQELKLNNNGLGdrGLRLLAKGLKDlppaLEKLVLGRNRL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 172 -----QSLPSELCGLSSLRDLNVRRNQLS-----TLPEELGDLP-LVRLDFSCNRVSRIPVS-----FCRLRHLQVILLD 235
Cdd:cd00116 150 egascEALAKALRANRDLKELNLANNGIGdagirALAEGLKANCnLEVLDLNNNGLTDEGASalaetLASLKSLEVLNLG 229

                       170
                ....*....|
gi 30181233 236 SNPLQSPPAQ 245
Cdd:cd00116 230 DNNLTDAGAA 239
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 92-126 1.58e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 30181233    92 SLEGLSLYHNCLRCLnPALGNLTALTYLNLSRNQL 126
Cdd:pfam12799   2 NLEVLDLSNNQITDI-PPLAKLPNLETLDLSGNNK 35
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 534-621 1.85e-03

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 39.05  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 534 VPDEKDLMTQLRQVLESRLQrplPEDLAEALASGVILCQLANQLRPR------SVPFIHVPSPAVP-KLSA----LKARK 602
Cdd:cd21269   5 VPMQEDLSIWLSGMLGKEVK---AERFMEELDNGVLLCQLIGVLQSKikeccsTEELKHFPMRKVPcKKDApsgsFFARD 81

                        90
                ....*....|....*....
gi 30181233 603 NVESFLEACRKMGVPEADL 621
Cdd:cd21269  82 NTANFLSWCRAIGVDETYL 100
CH_TAGLN-like cd21209
calponin homology (CH) domain found in the transgelin family; The transgelin (TAGLN) family ...
 554-630 3.75e-03

calponin homology (CH) domain found in the transgelin family; The transgelin (TAGLN) family includes transgelin, transgelin-2 and transgelin-3. Transgelin, also called 22 kDa actin-binding protein, protein WS3-10, or smooth muscle protein 22-alpha (SM22-alpha), acts as an actin cross-linking/gelling protein that may be involved in calcium interactions and in regulating contractile properties of the cell. Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates actin cytoskeleton. It may participate in the development and progression of multiple cancers. Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409058 [Multi-domain]  Cd Length: 119  Bit Score: 37.88  E-value: 3.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 554 RPLPEDLA--EALASGVILCQLANQLRPR-SVPFIHVPSPAVpklsALKARKNVESFLEACRKMGVPEADLCSPSDLLQG 630
Cdd:cd21209  22 RPDPGRLGfqKWLKDGTVLCKLINSLYPEgSKPVKKIQSSKM----AFKQMEQISQFLKAAEDYGVRTTDIFQTVDLWEG 97
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 534-621 4.25e-03

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 38.00  E-value: 4.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233 534 VPDEKDLMTQLRQVLESRLQrplPEDLAEALASGVILCQLANQLRP-------------RSVPFIHVPSPAVPKLSALKA 600
Cdd:cd21267   6 LPMKEDLALWLTNLLGKEIT---AESFMEKLDNGALLCQLAETLQEkfkensadankpgKSLPVRKIPCRANAPSGSFFA 82

                        90       100
                ....*....|....*....|.
gi 30181233 601 RKNVESFLEACRKMGVPEADL 621
Cdd:cd21267  83 RDNTANFLSWCRDVGVGDTCL 103
PLN03150 PLN03150
hypothetical protein; Provisional
 83-185 7.74e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 7.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30181233   83 VPEAACQLVSLEGLSLYHNCLR-CLNPALGNLTALTYLNLSRNQLS-LLPPYICQL-PLRVLIVSNNKL-GALPPDIGTL 158
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLtSLRILNLNGNSLsGRVPAALGGR 513

                         90       100
                 ....*....|....*....|....*...
gi 30181233  159 GSLR-QLDVSSNelqslpSELCGLSSLR 185
Cdd:PLN03150 514 LLHRaSFNFTDN------AGLCGIPGLR 535
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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