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LIF LIF interleukin 6 family cytokine [ Homo sapiens (human) ]

Gene ID: 3976, updated on 20-Dec-2019

Summary

Official Symbol
LIFprovided by HGNC
Official Full Name
LIF interleukin 6 family cytokineprovided by HGNC
Primary source
HGNC:HGNC:6596
See related
Ensembl:ENSG00000128342 MIM:159540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDF; DIA; HILDA; MLPLI
Summary
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Expression
Broad expression in gall bladder (RPKM 20.9), appendix (RPKM 11.6) and 16 other tissues See more
Orthologs

Genomic context

See LIF in Genome Data Viewer
Location:
22q12.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (30240453..30257487, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30636436..30642840, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10236 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1257 Neighboring gene LIF antisense RNA 1 Neighboring gene uncharacterized LOC91370 Neighboring gene oncostatin M Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants at five new loci associated with early-onset inflammatory bowel disease.
NHGRI GWA Catalog
Genome-wide association study identifies susceptibility loci for IgA nephropathy.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of leukemia inhibitory factor (LIF) expression as compared to untreated control PubMed
env Pretreatment of MAGI cells with human leukemia inhibitory factor results in a significantly reduced uptake of HIV-1 particles and downregulation of HIV-1 mediated STAT3 phosphorylation PubMed
env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
capsid gag Human LIF protein upregulates HIV-1 p24 production in the chronically infected promonocytes in a dose-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
leukemia inhibitory factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukemia inhibitory factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
leukemia inhibitory factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
decidualization IEA
Inferred from Electronic Annotation
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
leukemia inhibitory factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukemia inhibitory factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
lung lobe morphogenesis IEA
Inferred from Electronic Annotation
more info
 
lung vasculature development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
muscle organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
neuron development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of histone H3-K27 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of metanephric nephron tubule epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
spongiotrophoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
trophoblast giant cell differentiation IEA
Inferred from Electronic Annotation
more info
 
tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
leukemia inhibitory factor
Names
D factor
cholinergic differentiation factor
differentiation inhibitory activity
differentiation-inducing factor
differentiation-stimulating factor
hepatocyte-stimulating factor III
human interleukin in DA cells
melanoma-derived LPL inhibitor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008721.1 RefSeqGene

    Range
    5049..11355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001257135.2NP_001244064.1  leukemia inhibitory factor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC004264, AI796373, BC143305, CN409458
    Consensus CDS
    CCDS58799.1
    UniProtKB/Swiss-Prot
    P15018
    Related
    ENSP00000384450.3, ENST00000403987.3
  2. NM_002309.5NP_002300.1  leukemia inhibitory factor isoform 1 precursor

    See identical proteins and their annotated locations for NP_002300.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004264, AI796373, CN409458
    Consensus CDS
    CCDS13872.1
    UniProtKB/Swiss-Prot
    P15018
    Related
    ENSP00000249075.3, ENST00000249075.4
    Conserved Domains (1) summary
    smart00080
    Location:34191
    LIF_OSM; leukemia inhibitory factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    30240453..30257487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452239.1XP_024308007.1  leukemia inhibitory factor isoform X1

    Conserved Domains (1) summary
    smart00080
    Location:34191
    LIF_OSM; leukemia inhibitory factor
  2. XM_024452240.1XP_024308008.1  leukemia inhibitory factor isoform X1

    Conserved Domains (1) summary
    smart00080
    Location:34191
    LIF_OSM; leukemia inhibitory factor
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