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Lif leukemia inhibitory factor [ Mus musculus (house mouse) ]

Gene ID: 16878, updated on 26-Oct-2021

Summary

Official Symbol
Lifprovided by MGI
Official Full Name
leukemia inhibitory factorprovided by MGI
Primary source
MGI:MGI:96787
See related
Ensembl:ENSMUSG00000034394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Lif in Genome Data Viewer
Location:
11 A1; 11 2.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4207568..4222514)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4257568..4272514)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4157571..4172517)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11956 Neighboring gene oncostatin M Neighboring gene predicted gene 11958 Neighboring gene predicted gene, 53662 Neighboring gene predicted gene, 24803

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables leukemia inhibitory factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables leukemia inhibitory factor receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in animal organ regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within decidualization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo implantation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukemia inhibitory factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leukemia inhibitory factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung alveolus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung lobe morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung vasculature development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within maternal process involved in female pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of astrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of corticotropin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of histone H3-K27 acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of metanephric nephron tubule epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spongiotrophoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transdifferentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within trophoblast giant cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leukemia inhibitory factor
Names
d factor
differentiation-stimulating factor
myeloid leukaemia inhibitory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039537.2NP_001034626.1  leukemia inhibitory factor isoform b

    See identical proteins and their annotated locations for NP_001034626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL731658, BP765086, BY233044, X06381
    Consensus CDS
    CCDS24384.1
    UniProtKB/Swiss-Prot
    P09056
    UniProtKB/TrEMBL
    F8WH42
    Related
    ENSMUSP00000036853.4, ENSMUST00000040750.4
    Conserved Domains (1) summary
    smart00080
    Location:1147
    LIF_OSM; leukemia inhibitory factor
  2. NM_008501.2NP_032527.1  leukemia inhibitory factor isoform a precursor

    See identical proteins and their annotated locations for NP_032527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK042018, AL731658, BY207460
    Consensus CDS
    CCDS24383.1
    UniProtKB/Swiss-Prot
    P09056
    Related
    ENSMUSP00000067066.6, ENSMUST00000066283.12
    Conserved Domains (1) summary
    smart00080
    Location:35192
    LIF_OSM; leukemia inhibitory factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4207568..4222514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514542.5XP_006514605.1  leukemia inhibitory factor isoform X1

    See identical proteins and their annotated locations for XP_006514605.1

    UniProtKB/Swiss-Prot
    P09056
    Conserved Domains (1) summary
    smart00080
    Location:35192
    LIF_OSM; leukemia inhibitory factor
  2. XM_006514543.5XP_006514606.1  leukemia inhibitory factor isoform X1

    See identical proteins and their annotated locations for XP_006514606.1

    UniProtKB/Swiss-Prot
    P09056
    Conserved Domains (1) summary
    smart00080
    Location:35192
    LIF_OSM; leukemia inhibitory factor
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