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BGN biglycan [ Sus scrofa (pig) ]

Gene ID: 397396, updated on 5-Mar-2024

Summary

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Official Symbol
BGNprovided by VGNC
Official Full Name
biglycanprovided by VGNC
Primary source
VGNC:VGNC:85811
See related
Ensembl:ENSSSCG00000012766
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in subcutaneous adipose (RPKM 172.0), ovary (RPKM 116.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) X NC_010461.5 (124282048..124295450)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) X NC_010461.4 (141845604..141858856)

Chromosome X - NC_010461.5Genomic Context describing neighboring genes Neighboring gene HAUS augmin like complex subunit 7 Neighboring gene three prime repair exonuclease 2 Neighboring gene extracellular matrix protein X-linked Neighboring gene ATPase plasma membrane Ca2+ transporting 3 Neighboring gene cyclin Q

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix. Neufeld EB, et al. Atherosclerosis, 2014 Mar. PMID 24529131, Free PMC Article
  2. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Barallobre-Barreiro J, et al. Circulation, 2012 Feb 14. PMID 22261194

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LDL electrostatic interactions with decorin and biglycan in the aortic valve leaflets and vascular wall is a major source of LDL retention.
    Title: Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
biglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010461.5 Reference Sscrofa11.1 Primary Assembly

    Range
    124282048..124295450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003135475.5 → XP_003135523.1  biglycan isoform X2

    UniProtKB/TrEMBL
    A0A5K1UKC5, A0A8D0ZSX8, A0A8D1TM90
    Related
    ENSSSCP00000029666.3, ENSSSCT00000034816.4
    Conserved Domains (5) summary
    smart00013
    Location:63 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:96 → 323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:303 → 316
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:72 → 92
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:94 → 151
    LRR_8; Leucine rich repeat

  2. XM_013986528.2 → XP_013841982.2  biglycan isoform X1

    UniProtKB/TrEMBL
    A0A8D0ZS93, A0A8D1J0M9
    Conserved Domains (3) summary
    sd00033
    Location:72 → 92
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:293 → 352
    LRR_8; Leucine rich repeat
    cl26018
    Location:65 → 289
    NEL; C-terminal novel E3 ligase, LRR-interacting
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GKQ6.2 GenPept UniProtKB/Swiss-Prot:Q9GKQ6

Gene LinkOut

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