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Bgn biglycan [ Mus musculus (house mouse) ]

Gene ID: 12111, updated on 27-Nov-2024

Summary

Official Symbol
Bgnprovided by MGI
Official Full Name
biglycanprovided by MGI
Primary source
MGI:MGI:88158
See related
Ensembl:ENSMUSG00000031375 AllianceGenome:MGI:88158
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BG; PGI; DSPG1; PG-S1; SLRR1A
Summary
This gene encodes a small, leucine-rich repeat proteoglycan that plays important roles in bone mineralization and connective tissue metabolism. The encoded preproprotein undergoes post-translational processing during which chondroitin sulfate or dermatan sulfate chains are attached before incorporation into the extracellular matrix. Mice lacking the encoded protein exhibit reduced growth rate and acquire diminished bone mass progressively with age. [provided by RefSeq, Oct 2015]
Expression
Broad expression in bladder adult (RPKM 238.1), lung adult (RPKM 231.1) and 22 other tissues See more
Orthologs
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Genomic context

See Bgn in Genome Data Viewer
Location:
X A7.3; X 37.33 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72527207..72539542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73483601..73495936)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene three prime repair exonuclease 2 Neighboring gene HAUS augmin-like complex, subunit 7 Neighboring gene ATPase, Ca++ transporting, plasma membrane 3 Neighboring gene cyclin Q, pseudogene 1 Neighboring gene predicted gene, 46680

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within articular cartilage development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within bone development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
biglycan
Names
bone/cartilage proteoglycan I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411776.1NP_001398705.1  biglycan isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL732461
  2. NM_007542.5NP_031568.2  biglycan isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_031568.2

    Status: REVIEWED

    Source sequence(s)
    AK164867, AL732461
    Consensus CDS
    CCDS30204.1
    UniProtKB/Swiss-Prot
    P28653, Q61355
    UniProtKB/TrEMBL
    Q3TNY9, Q3UXK8
    Related
    ENSMUSP00000033741.8, ENSMUST00000033741.15
    Conserved Domains (4) summary
    smart00013
    Location:6395
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:96323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:7292
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:94151
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72527207..72539542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)