Format

Send to:

Choose Destination

BGN biglycan [ Homo sapiens (human) ]

Gene ID: 633, updated on 18-Aug-2020

Summary

Official Symbol
BGNprovided by HGNC
Official Full Name
biglycanprovided by HGNC
Primary source
HGNC:HGNC:1044
See related
Ensembl:ENSG00000182492 MIM:301870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGI; MRLS; DSPG1; PG-S1; SEMDX; SLRR1A
Summary
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
Expression
Broad expression in gall bladder (RPKM 206.5), spleen (RPKM 159.3) and 20 other tissues See more
Orthologs

Genomic context

See BGN in Genome Data Viewer
Location:
Xq28
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (153494980..153509546)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152760347..152775004)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene HAUS augmin like complex subunit 7 Neighboring gene Sharpr-MPRA regulatory region 9358 Neighboring gene extracellular matrix protein X-linked, pseudogene Neighboring gene ATPase plasma membrane Ca2+ transporting 3 Neighboring gene cyclin Q

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix structural constituent NAS
Non-traceable Author Statement
more info
PubMed 
extracellular matrix structural constituent conferring compression resistance ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
glycosaminoglycan binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
articular cartilage development IEA
Inferred from Electronic Annotation
more info
 
biological_process ND
No biological Data available
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
bone development IEA
Inferred from Electronic Annotation
more info
 
chondroitin sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
chondroitin sulfate catabolic process TAS
Traceable Author Statement
more info
 
dermatan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal lumen TAS
Traceable Author Statement
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
transport vesicle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
biglycan
Names
bone/cartilage proteoglycan-I
dermatan sulphate proteoglycan I
small leucine-rich protein 1A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015961.1 RefSeqGene

    Range
    5028..19594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001711.6NP_001702.1  biglycan preproprotein

    See identical proteins and their annotated locations for NP_001702.1

    Status: REVIEWED

    Source sequence(s)
    AI538325, AK297966, BC002416, BQ180984, DC299956
    Consensus CDS
    CCDS14721.1
    UniProtKB/Swiss-Prot
    P21810
    UniProtKB/TrEMBL
    B4DNL4
    Related
    ENSP00000327336.4, ENST00000331595.9
    Conserved Domains (4) summary
    sd00031
    Location:302315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:7191
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:277323
    LRR_8; Leucine rich repeat
    cl26018
    Location:64297
    NEL; C-terminal novel E3 ligase, LRR-interacting

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    153494980..153509546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029724.2XP_016885213.1  biglycan isoform X1

    UniProtKB/Swiss-Prot
    P21810
    Conserved Domains (4) summary
    sd00031
    Location:302315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:7191
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:277323
    LRR_8; Leucine rich repeat
    cl26018
    Location:64297
    NEL; C-terminal novel E3 ligase, LRR-interacting
Support Center