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LAMA5 laminin subunit alpha 5 [ Homo sapiens (human) ]

Gene ID: 3911, updated on 5-Apr-2020

Summary

Official Symbol
LAMA5provided by HGNC
Official Full Name
laminin subunit alpha 5provided by HGNC
Primary source
HGNC:HGNC:6485
See related
Ensembl:ENSG00000130702 MIM:601033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
Expression
Broad expression in skin (RPKM 18.3), placenta (RPKM 17.0) and 24 other tissues See more
Orthologs

Genomic context

See LAMA5 in Genome Data Viewer
Location:
20q13.33
Exon count:
81
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (62309060..62367318, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60884116..60942368, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 2 Neighboring gene uncharacterized LOC105372707 Neighboring gene adhesion regulating molecule 1 Neighboring gene Sharpr-MPRA regulatory region 11098 Neighboring gene microRNA 4758 Neighboring gene LAMA5 antisense RNA 1 Neighboring gene uncharacterized LOC105372708 Neighboring gene ribosomal protein S21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
NHGRI GWA Catalog
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins PubMed
Tat tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat enhances adhesion of human U937 monocyte-like cells to proteins of the extracellular matrix, such as collagen IV, laminin, and ECM1 PubMed
tat HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1907

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of a polarized epithelium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
morphogenesis of embryonic epithelium IEA
Inferred from Electronic Annotation
more info
 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
basement membrane NAS
Non-traceable Author Statement
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
laminin-10 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-10 complex TAS
Traceable Author Statement
more info
PubMed 
laminin-11 complex TAS
Traceable Author Statement
more info
PubMed 
laminin-5 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
synaptic cleft IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
laminin subunit alpha-5
Names
laminin alpha-5 chain
laminin-10 subunit alpha
laminin-11 subunit alpha
laminin-15 subunit alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050626.1 RefSeqGene

    Range
    5009..63261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005560.6NP_005551.3  laminin subunit alpha-5 precursor

    See identical proteins and their annotated locations for NP_005551.3

    Status: REVIEWED

    Source sequence(s)
    AL354836
    Consensus CDS
    CCDS33502.1
    UniProtKB/Swiss-Prot
    O15230
    Related
    ENSP00000252999.3, ENST00000252999.7
    Conserved Domains (11) summary
    smart00180
    Location:20232067
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00282
    Location:27812908
    LamG; Laminin G domain
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:33403497
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00052
    Location:16931818
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:15771625
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:54298
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam04012
    Location:24352695
    PspA_IM30; PspA/IM30 family
    pfam06008
    Location:21882450
    Laminin_I; Laminin Domain I
    pfam06009
    Location:26412762
    Laminin_II; Laminin Domain II
    cd16172
    Location:22872578
    TorS_sensor_domain; sensor domain of the sensor histidine kinase TorS

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    62309060..62367318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528819.2XP_011527121.1  laminin subunit alpha-5 isoform X3

    Conserved Domains (11) summary
    smart00180
    Location:19321976
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00282
    Location:26902817
    LamG; Laminin G domain
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:32543411
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00052
    Location:16021727
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:14861534
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:54298
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam04012
    Location:23442604
    PspA_IM30; PspA/IM30 family
    pfam06008
    Location:20972359
    Laminin_I; Laminin Domain I
    pfam06009
    Location:25502671
    Laminin_II; Laminin Domain II
    cd16172
    Location:21962487
    TorS_sensor_domain; sensor domain of the sensor histidine kinase TorS
  2. XM_011528818.2XP_011527120.1  laminin subunit alpha-5 isoform X2

    Conserved Domains (11) summary
    smart00180
    Location:19772021
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00282
    Location:27352862
    LamG; Laminin G domain
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:32993456
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00052
    Location:16471772
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:15311579
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:54298
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam04012
    Location:23892649
    PspA_IM30; PspA/IM30 family
    pfam06008
    Location:21422404
    Laminin_I; Laminin Domain I
    pfam06009
    Location:25952716
    Laminin_II; Laminin Domain II
    cd16172
    Location:22412532
    TorS_sensor_domain; sensor domain of the sensor histidine kinase TorS
  3. XM_006723796.3XP_006723859.1  laminin subunit alpha-5 isoform X1

    Conserved Domains (11) summary
    smart00180
    Location:20232067
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00282
    Location:27812908
    LamG; Laminin G domain
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:33453502
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00052
    Location:16931818
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:15771625
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:54298
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam04012
    Location:24352695
    PspA_IM30; PspA/IM30 family
    pfam06008
    Location:21882450
    Laminin_I; Laminin Domain I
    pfam06009
    Location:26412762
    Laminin_II; Laminin Domain II
    cd16172
    Location:22872578
    TorS_sensor_domain; sensor domain of the sensor histidine kinase TorS
  4. XM_006723798.3XP_006723861.1  laminin subunit alpha-5 isoform X4

    Conserved Domains (6) summary
    smart00180
    Location:20232065
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:540583
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00052
    Location:16931818
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:15771625
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:54298
    Laminin_N; Laminin N-terminal (Domain VI)
    cl21504
    Location:21172145
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RNA

  1. XR_936532.2 RNA Sequence

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