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Zfp667 zinc finger protein 667 [ Mus musculus (house mouse) ]

Gene ID: 384763, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp667provided by MGI
Official Full Name
zinc finger protein 667provided by MGI
Primary source
MGI:MGI:2442757
See related
Ensembl:ENSMUSG00000054893 AllianceGenome:MGI:2442757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mip1; ZNF667; A830025F02Rik
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in limb. Orthologous to human ZNF667 (zinc finger protein 667). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in placenta adult (RPKM 4.5), bladder adult (RPKM 2.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp667 in Genome Data Viewer
Location:
7 A1; 7 3.64 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6289187..6310882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6286195..6307883)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 5B Neighboring gene STARR-seq mESC enhancer starr_17972 Neighboring gene epididymal protein 13 Neighboring gene STARR-positive B cell enhancer ABC_E11341 Neighboring gene STARR-seq mESC enhancer starr_17975 Neighboring gene STARR-positive B cell enhancer ABC_E4894 Neighboring gene zinc finger protein 583 Neighboring gene predicted gene, 38944 Neighboring gene zinc finger protein 582

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mipu1 inhibits lipid accumulation through down-regulation of CD36 in RAW264.7 cells. Qu SL, et al. Cell Physiol Biochem, 2015. PMID 26383633
  2. IL9 Polarizes Macrophages to M1 and Induces the Infiltration of Antitumor Immune Cells via MIP-1 and CXCR3 Chemokines. Do-Thi VA, et al. Cancer Res Commun, 2023 Jan. PMID 36968220, Free PMC Article
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 667
Names
myocardial ischemic preconditioning up-regulated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024928.2 → NP_001020099.1  zinc finger protein 667

    See identical proteins and their annotated locations for NP_001020099.1

    Status: VALIDATED

    Source sequence(s)
    AY850275
    Consensus CDS
    CCDS20773.1
    UniProtKB/Swiss-Prot
    B2RUH6, Q2TL60
    Related
    ENSMUSP00000083507.6, ENSMUST00000086327.12
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    6289187..6310882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540156.5 → XP_006540219.1  zinc finger protein 667 isoform X1

    See identical proteins and their annotated locations for XP_006540219.1

    UniProtKB/Swiss-Prot
    B2RUH6, Q2TL60
    Related
    ENSMUSP00000104202.2, ENSMUST00000108562.2
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036153211.1 → XP_036009104.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RUH6, Q2TL60
    Related
    ENSMUSP00000128658.2, ENSMUST00000170776.8
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_017322332.3 → XP_017177821.1  zinc finger protein 667 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:225 → 385
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285 → 305
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_006540154.4 → XP_006540217.1  zinc finger protein 667 isoform X1

    See identical proteins and their annotated locations for XP_006540217.1

    UniProtKB/Swiss-Prot
    B2RUH6, Q2TL60
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_006540153.5 → XP_006540216.1  zinc finger protein 667 isoform X1

    See identical proteins and their annotated locations for XP_006540216.1

    UniProtKB/Swiss-Prot
    B2RUH6, Q2TL60
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036153210.1 → XP_036009103.1  zinc finger protein 667 isoform X1

    UniProtKB/Swiss-Prot
    B2RUH6, Q2TL60
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_006540155.1 → XP_006540218.1  zinc finger protein 667 isoform X1

    See identical proteins and their annotated locations for XP_006540218.1

    UniProtKB/Swiss-Prot
    B2RUH6, Q2TL60
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:141 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_011250620.4 → XP_011248922.1  zinc finger protein 667 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:65 → 524
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TL60.1 GenPept UniProtKB/Swiss-Prot:Q2TL60

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