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KIR3DL1 killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 [ Homo sapiens (human) ]

Gene ID: 3811, updated on 1-Jun-2020

Summary

Official Symbol
KIR3DL1provided by HGNC
Official Full Name
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1provided by HGNC
Primary source
HGNC:HGNC:6338
See related
Ensembl:ENSG00000167633 MIM:604946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIR; NKB1; NKAT3; NKB1B; NKAT-3; CD158E1; KIR3DL1/S1
Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KIR3DL1 in Genome Data Viewer
Location:
19q13.42
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (54816438..54830778)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55327893..55342233)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env KIR3DL1+ NK cells can partially overcome inhibition to exhibit anti-HIV-1 Ab-dependent activation of NK cells, leading to suppress target cells presenting to HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119726, MGC119728, MGC126589, MGC126591

Gene Ontology Provided by GOA

Function Evidence Code Pubs
HLA-B specific inhibitory MHC class I receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
NOT amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
immune response NAS
Non-traceable Author Statement
more info
PubMed 
natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
killer cell immunoglobulin-like receptor 3DL1
Names
CD158 antigen-like family member E
HLA-BW4-specific inhibitory NK cell receptor
KIR antigen 3DL1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
natural killer-associated transcript 3
p70 NK receptor CL-2/CL-11
p70 killer cell inhibitory receptor
p70 natural killer cell receptor clones CL-2/CL-11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021414.2 RefSeqGene

    Range
    5001..19341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322168.1NP_001309097.1  killer cell immunoglobulin-like receptor 3DL1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents an alternate allele of the KIR3DL1 gene, as represented in ALT_REF_LOCI_30.
    Source sequence(s)
    AY366236, BC028206, U30274
    UniProtKB/Swiss-Prot
    P43629
    UniProtKB/TrEMBL
    Q6H2G3, Q8N6C9
    Conserved Domains (3) summary
    cd05711
    Location:123217
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    smart00410
    Location:3598
    IG_like; Immunoglobulin like
    cl11960
    Location:223311
    Ig; Immunoglobulin domain
  2. NM_013289.2NP_037421.2  killer cell immunoglobulin-like receptor 3DL1 precursor

    See identical proteins and their annotated locations for NP_037421.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the reference genome allele of the KIR3DL1 gene.
    Source sequence(s)
    BC028206, U30274
    Consensus CDS
    CCDS42621.1
    UniProtKB/Swiss-Prot
    P43629
    UniProtKB/TrEMBL
    Q5UCE2, Q8N6C9
    Related
    ENSP00000375608.4, ENST00000391728.8
    Conserved Domains (2) summary
    cd05711
    Location:123217
    Ig2_LILR_KIR_like; Second immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, natural and similar domains
    cl11960
    Location:223311
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    54816438..54830778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107300.1 Reference GRCh38.p13 PATCHES

    Range
    118073..132434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107301.1 Reference GRCh38.p13 PATCHES

    Range
    118081..132421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107302.1 Reference GRCh38.p13 PATCHES

    Range
    118075..132416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107305.1 Reference GRCh38.p13 PATCHES

    Range
    118064..132407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107306.1 Reference GRCh38.p13 PATCHES

    Range
    117888..132231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107307.1 Reference GRCh38.p13 PATCHES

    Range
    118037..132378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107309.1 Reference GRCh38.p13 PATCHES

    Range
    118075..132416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107313.1 Reference GRCh38.p13 PATCHES

    Range
    118040..132383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107314.1 Reference GRCh38.p13 PATCHES

    Range
    104428..118768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NW_003571056.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    753983..760403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017030274.1XP_016885763.1  killer cell immunoglobulin-like receptor 3DL1 isoform X1

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    720804..735147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p13 ALT_REF_LOCI_9

    Range
    799007..813347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_11

Genomic

  1. NT_187637.1 Reference GRCh38.p13 ALT_REF_LOCI_11

    Range
    38030..52371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_12

Genomic

  1. NT_187638.1 Reference GRCh38.p13 ALT_REF_LOCI_12

    Range
    38231..52575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_13

Genomic

  1. NT_187639.1 Reference GRCh38.p13 ALT_REF_LOCI_13

    Range
    38595..52938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_14

Genomic

  1. NT_187640.1 Reference GRCh38.p13 ALT_REF_LOCI_14

    Range
    27422..41766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_16

Genomic

  1. NT_187642.1 Reference GRCh38.p13 ALT_REF_LOCI_16

    Range
    36724..51067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_17

Genomic

  1. NT_187643.1 Reference GRCh38.p13 ALT_REF_LOCI_17

    Range
    38286..52629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_19

Genomic

  1. NT_187645.1 Reference GRCh38.p13 ALT_REF_LOCI_19

    Range
    38301..52644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_20

Genomic

  1. NT_187668.1 Reference GRCh38.p13 ALT_REF_LOCI_20

    Range
    28192..42533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_21

Genomic

  1. NT_187669.1 Reference GRCh38.p13 ALT_REF_LOCI_21

    Range
    38286..52629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_23

Genomic

  1. NT_187671.1 Reference GRCh38.p13 ALT_REF_LOCI_23

    Range
    95381..109724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_24

Genomic

  1. NT_187672.1 Reference GRCh38.p13 ALT_REF_LOCI_24

    Range
    118071..122021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_25

Genomic

  1. NT_187673.1 Reference GRCh38.p13 ALT_REF_LOCI_25

    Range
    38300..52640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_26

Genomic

  1. NT_187674.1 Reference GRCh38.p13 ALT_REF_LOCI_26

    Range
    103310..117653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_28

Genomic

  1. NT_187676.1 Reference GRCh38.p13 ALT_REF_LOCI_28

    Range
    92381..106724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_29

Genomic

  1. NT_187677.1 Reference GRCh38.p13 ALT_REF_LOCI_29

    Range
    93804..108144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_30

Genomic

  1. NT_187683.1 Reference GRCh38.p13 ALT_REF_LOCI_30

    Range
    90646..104990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_31

Genomic

  1. NT_187684.1 Reference GRCh38.p13 ALT_REF_LOCI_31

    Range
    38088..52446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_32

Genomic

  1. NT_187685.1 Reference GRCh38.p13 ALT_REF_LOCI_32

    Range
    37780..52121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_33

Genomic

  1. NT_187686.1 Reference GRCh38.p13 ALT_REF_LOCI_33

    Range
    38631..52972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_34

Genomic

  1. NT_187687.1 Reference GRCh38.p13 ALT_REF_LOCI_34

    Range
    38106..52466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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