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Susceptibility to HIV infection

MedGen UID:
332156
•Concept ID:
C1836230
•
Finding
Synonyms: HIV-1, SUSCEPTIBILITY TO; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, RESISTANCE TO; Human immunodeficiency virus type 1, susceptibility to
 
Genes (locations): CCL11 (17q12); CCL2 (17q12); CCL3 (17q12); CCL3L1; CCL5 (17q12); CCR2 (3p21.31); CCR5 (3p21.31); CD209 (19p13.2); CX3CR1 (3p22.2); CXCL12 (10q11.21); CXCR1 (2q35); HLA-C (6p21.33); IFNG (12q15); IL10 (1q32.1); TLR3 (4q35.1)
 
Monarch Initiative: MONDO:0004951
OMIM®: 609423

Definition

The pathogenesis of HIV infection and the progression from infection to AIDS vary significantly between exposed individuals. Infection occurs after the virus, which has macrophage (M)- and T lymphocyte (T)-tropic strains and more than 12 subtypes, survives an array of nonspecific, nongenetic environmental and host factors. [from OMIM]

Professional guidelines

PubMed

Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point.
Alsulami K, Bolastig N, Dupuy FP, Mabanga T, Gilbert L, Kiani Z, Routy JP, Bruneau J, Thomas R, Tremblay C, Tsoukas CM, Szabo J, Côté P, Trottier B, LeBlanc R, Rouleau D, Bernard NF; investigators in the Montreal Primary HIV Infection cohort
J Virol 2021 Jul 26;95(16):e0041721. doi: 10.1128/JVI.00417-21. PMID: 34076484Free PMC Article
Protective Effect of the Combination of Wild-Type Genotypes (G/G and G/G) of CCR2-64V and SDF1-3A' Genes in Serodiscordant Couples in Yaounde-Cameroon.
Nkenfou CN, Tchakounté C, Nkenfou-Tchinda CN, Ngoufack MN, Yatchou LG, Elong E, Kamgaing R, Tiga A, Ambada G, Kuiate JR, Ndjolo A
Curr HIV Res 2021;19(4):342-351. doi: 10.2174/1570162X19666210412121143. PMID: 33845725
Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection.
Marmor M, Sheppard HW, Donnell D, Bozeman S, Celum C, Buchbinder S, Koblin B, Seage GR 3rd; HIV Network for Prevention Trials Vaccine Preparedness Protocol Team
J Acquir Immune Defic Syndr 2001 Aug 15;27(5):472-81. doi: 10.1097/00126334-200108150-00009. PMID: 11511825

Recent clinical studies

Etiology

Influence of Hormonal Contraceptive Use and HIV on Cervicovaginal Cytokines and Microbiota in Malawi.
Haddad LB, Tang JH, Davis NL, Kourtis AP, Chinula L, Msika A, Tegha G, Hosseinipour MC, Nelson JAE, Hobbs MM, Gajer P, Ravel J, De Paris K
mSphere 2023 Feb 21;8(1):e0058522. Epub 2023 Jan 9 doi: 10.1128/msphere.00585-22. PMID: 36622252Free PMC Article
Facilitators, Barriers, and Outcomes of Self-Initiated HIV Testing: An Integrative Literature Review.
Adebayo OW, Salerno JP
Res Theory Nurs Pract 2019 Aug 1;33(3):275-291. doi: 10.1891/1541-6577.33.3.275. PMID: 31615946
Addressing the structural drivers of HIV: a luxury or necessity for programmes?
Seeley J, Watts CH, Kippax S, Russell S, Heise L, Whiteside A
J Int AIDS Soc 2012;15 Suppl 1(Suppl 1):1-4. doi: 10.7448/IAS.15.3.17397. PMID: 22905346Free PMC Article
Host factors involved in low susceptibility to HIV infection.
Restrepo C, Rallón NI, Carrillo J, Soriano V, Blanco J, Benito JM
AIDS Rev 2011 Jan-Mar;13(1):30-40. PMID: 21412387
Host factors influencing susceptibility to HIV infection and AIDS progression.
Lama J, Planelles V
Retrovirology 2007 Jul 25;4:52. doi: 10.1186/1742-4690-4-52. PMID: 17651505Free PMC Article

Diagnosis

Influence of sickle cell disease on susceptibility to HIV infection.
Kelly S, Jacobs ES, Stone M, Keating SM, Lee TH, Chafets D, Heitman J, Dimapasoc M, Operskalski E, Hagar W, Vichinsky E, Busch MP, Norris PJ, Custer B; Recipient Epidemiology and Donor Evaluation Study (REDS-III)
PLoS One 2020;15(4):e0218880. Epub 2020 Apr 8 doi: 10.1371/journal.pone.0218880. PMID: 32267841Free PMC Article
Facilitators, Barriers, and Outcomes of Self-Initiated HIV Testing: An Integrative Literature Review.
Adebayo OW, Salerno JP
Res Theory Nurs Pract 2019 Aug 1;33(3):275-291. doi: 10.1891/1541-6577.33.3.275. PMID: 31615946
Addressing the structural drivers of HIV: a luxury or necessity for programmes?
Seeley J, Watts CH, Kippax S, Russell S, Heise L, Whiteside A
J Int AIDS Soc 2012;15 Suppl 1(Suppl 1):1-4. doi: 10.7448/IAS.15.3.17397. PMID: 22905346Free PMC Article
Immunogenetics of HIV and HIV associated tuberculosis.
Raghavan S, Alagarasu K, Selvaraj P
Tuberculosis (Edinb) 2012 Jan;92(1):18-30. Epub 2011 Sep 22 doi: 10.1016/j.tube.2011.08.004. PMID: 21943869
Bacterial vaginosis and susceptibility to HIV infection in South African women: a nested case-control study.
Myer L, Denny L, Telerant R, Souza Md, Wright TC Jr, Kuhn L
J Infect Dis 2005 Oct 15;192(8):1372-80. Epub 2005 Sep 9 doi: 10.1086/462427. PMID: 16170754

Therapy

Influence of Hormonal Contraceptive Use and HIV on Cervicovaginal Cytokines and Microbiota in Malawi.
Haddad LB, Tang JH, Davis NL, Kourtis AP, Chinula L, Msika A, Tegha G, Hosseinipour MC, Nelson JAE, Hobbs MM, Gajer P, Ravel J, De Paris K
mSphere 2023 Feb 21;8(1):e0058522. Epub 2023 Jan 9 doi: 10.1128/msphere.00585-22. PMID: 36622252Free PMC Article
Acceptability of the Dapivirine Vaginal Ring in Postmenopausal US Women.
Shapley-Quinn MK, Laborde N, Luecke E, Hoesley C, Salata RA, Johnson S, Nel A, Soto-Torres L, Chen BA, van der Straten A
AIDS Patient Care STDS 2022 Mar;36(3):97-105. doi: 10.1089/apc.2022.0002. PMID: 35289688Free PMC Article
Influence of sickle cell disease on susceptibility to HIV infection.
Kelly S, Jacobs ES, Stone M, Keating SM, Lee TH, Chafets D, Heitman J, Dimapasoc M, Operskalski E, Hagar W, Vichinsky E, Busch MP, Norris PJ, Custer B; Recipient Epidemiology and Donor Evaluation Study (REDS-III)
PLoS One 2020;15(4):e0218880. Epub 2020 Apr 8 doi: 10.1371/journal.pone.0218880. PMID: 32267841Free PMC Article
Phenotype and susceptibility to HIV infection of CD4+ Th17 cells in the human female reproductive tract.
Rodriguez-Garcia M, Barr FD, Crist SG, Fahey JV, Wira CR
Mucosal Immunol 2014 Nov;7(6):1375-85. Epub 2014 Apr 23 doi: 10.1038/mi.2014.26. PMID: 24759207Free PMC Article
The genetic basis of resistance to HIV infection and disease progression.
Biasin M, De Luca M, Gnudi F, Clerici M
Expert Rev Clin Immunol 2013 Apr;9(4):319-34. doi: 10.1586/eci.13.16. PMID: 23557268

Prognosis

Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point.
Alsulami K, Bolastig N, Dupuy FP, Mabanga T, Gilbert L, Kiani Z, Routy JP, Bruneau J, Thomas R, Tremblay C, Tsoukas CM, Szabo J, Côté P, Trottier B, LeBlanc R, Rouleau D, Bernard NF; investigators in the Montreal Primary HIV Infection cohort
J Virol 2021 Jul 26;95(16):e0041721. doi: 10.1128/JVI.00417-21. PMID: 34076484Free PMC Article
HIV vaccine acceptability: a systematic review and meta-analysis.
Newman PA, Logie C
AIDS 2010 Jul 17;24(11):1749-56. doi: 10.1097/qad.0b013e32833adbe8. PMID: 20597165
Genetic determinants of HIV-1 infection and progression to AIDS: susceptibility to HIV infection.
Kaur G, Mehra N
Tissue Antigens 2009 Apr;73(4):289-301. doi: 10.1111/j.1399-0039.2009.01220.x. PMID: 19317737Free PMC Article
AIDS and reproductive health.
Coggins C, Segal S
J Reprod Immunol 1998 Dec;41(1-2):3-15. doi: 10.1016/s0165-0378(98)00045-x. PMID: 10213297
Health beliefs and intention to get immunized for HIV.
Zimet GD, Liau A, Fortenberry VD
J Adolesc Health 1997 May;20(5):354-9. doi: 10.1016/s1054-139x(97)00031-1. PMID: 9168382

Clinical prediction guides

Influence of Hormonal Contraceptive Use and HIV on Cervicovaginal Cytokines and Microbiota in Malawi.
Haddad LB, Tang JH, Davis NL, Kourtis AP, Chinula L, Msika A, Tegha G, Hosseinipour MC, Nelson JAE, Hobbs MM, Gajer P, Ravel J, De Paris K
mSphere 2023 Feb 21;8(1):e0058522. Epub 2023 Jan 9 doi: 10.1128/msphere.00585-22. PMID: 36622252Free PMC Article
Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids.
Gumbs SBH, Berdenis van Berlekom A, Kübler R, Schipper PJ, Gharu L, Boks MP, Ormel PR, Wensing AMJ, de Witte LD, Nijhuis M
Viruses 2022 Apr 16;14(4) doi: 10.3390/v14040829. PMID: 35458559Free PMC Article
Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analyses.
Gumbs SBH, Kübler R, Gharu L, Schipper PJ, Borst AL, Snijders GJLJ, Ormel PR, van Berlekom AB, Wensing AMJ, de Witte LD, Nijhuis M
J Neurovirol 2022 Feb;28(1):64-91. Epub 2022 Feb 9 doi: 10.1007/s13365-021-01049-w. PMID: 35138593Free PMC Article
Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point.
Alsulami K, Bolastig N, Dupuy FP, Mabanga T, Gilbert L, Kiani Z, Routy JP, Bruneau J, Thomas R, Tremblay C, Tsoukas CM, Szabo J, Côté P, Trottier B, LeBlanc R, Rouleau D, Bernard NF; investigators in the Montreal Primary HIV Infection cohort
J Virol 2021 Jul 26;95(16):e0041721. doi: 10.1128/JVI.00417-21. PMID: 34076484Free PMC Article
Genetic determinants of HIV-1 infection and progression to AIDS: susceptibility to HIV infection.
Kaur G, Mehra N
Tissue Antigens 2009 Apr;73(4):289-301. doi: 10.1111/j.1399-0039.2009.01220.x. PMID: 19317737Free PMC Article

Recent systematic reviews

HIV vaccine acceptability: a systematic review and meta-analysis.
Newman PA, Logie C
AIDS 2010 Jul 17;24(11):1749-56. doi: 10.1097/qad.0b013e32833adbe8. PMID: 20597165
Intravaginal practices, vaginal infections and HIV acquisition: systematic review and meta-analysis.
Hilber AM, Francis SC, Chersich M, Scott P, Redmond S, Bender N, Miotti P, Temmerman M, Low N
PLoS One 2010 Feb 9;5(2):e9119. doi: 10.1371/journal.pone.0009119. PMID: 20161749Free PMC Article

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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