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ITGA3 integrin subunit alpha 3 [ Homo sapiens (human) ]

Gene ID: 3675, updated on 17-Apr-2020

Summary

Official Symbol
ITGA3provided by HGNC
Official Full Name
integrin subunit alpha 3provided by HGNC
Primary source
HGNC:HGNC:6139
See related
Ensembl:ENSG00000005884 MIM:605025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3
Summary
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
Expression
Broad expression in lung (RPKM 53.0), thyroid (RPKM 21.5) and 19 other tissues See more
Orthologs

Genomic context

See ITGA3 in Genome Data Viewer
Location:
17q21.33
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50056065..50090481)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48133340..48167849)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene distal-less homeobox 3 Neighboring gene p53 inducible cancer associated RNA transcript 1 Neighboring gene pyruvate dehydrogenase kinase 2 Neighboring gene sterile alpha motif domain containing 14 Neighboring gene protein phosphatase 1 regulatory subunit 9B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
Tat tat Activation of primary T cells by HIV-1 Tat involves integrin receptors and monoclonal antibodies to integrin alpha 3 inhibit Tat-induced upregulation of CD25 PubMed
retropepsin gag-pol Beta4 integrin and alpha3 integrin are cleaved by the HIV-1 protease in human embryonic fibroblasts PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33213, FLJ34631, FLJ34704, FLJ37821

Gene Ontology Provided by GOA

Function Evidence Code Pubs
collagen binding IEA
Inferred from Electronic Annotation
more info
 
fibronectin binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
laminin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
dendritic spine maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
exploration behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
mesodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell projection organization IEA
Inferred from Electronic Annotation
more info
 
nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to gonadotropin IEA
Inferred from Electronic Annotation
more info
 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface HDA PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
filopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
growth cone filopodium IEA
Inferred from Electronic Annotation
more info
 
integrin alpha3-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alpha3-beta1 complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin complex TAS
Traceable Author Statement
more info
PubMed 
invadopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
synaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
integrin alpha-3
Names
CD49 antigen-like family member C
alpha 3 subunit of VLA-3 receptor
antigen CD49C
antigen identified by monoclonal antibody J143
galactoprotein B3
integrin alpha 3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
testicular tissue protein Li 96
testicular tissue protein Li 98
very late activation protein 3 receptor, alpha-3 subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029107.2 RefSeqGene

    Range
    5135..39506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002204.4NP_002195.1  integrin alpha-3 preproprotein

    See identical proteins and their annotated locations for NP_002195.1

    Status: REVIEWED

    Source sequence(s)
    AK289961, BC150190, BU631476, DA655978
    Consensus CDS
    CCDS11558.1
    UniProtKB/Swiss-Prot
    P26006
    UniProtKB/TrEMBL
    A0A140VJM0
    Related
    ENSP00000315190.8, ENST00000320031.13
    Conserved Domains (2) summary
    smart00191
    Location:365417
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:462916
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50056065..50090481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257308.2XP_005257365.1  integrin alpha-3 isoform X1

    Conserved Domains (2) summary
    smart00191
    Location:48108
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:327781
    Integrin_alpha2; Integrin alpha

RNA

  1. XR_001752507.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005501.2: Suppressed sequence

    Description
    NM_005501.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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