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Itga3 integrin alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 16400, updated on 9-Mar-2023

Summary

Official Symbol
Itga3provided by MGI
Official Full Name
integrin alpha 3provided by MGI
Primary source
MGI:MGI:96602
See related
Ensembl:ENSMUSG00000001507 AllianceGenome:MGI:96602
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD49C; GAPB3
Summary
This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression
Broad expression in lung adult (RPKM 73.3), duodenum adult (RPKM 44.4) and 20 other tissues See more
Orthologs
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Genomic context

See Itga3 in Genome Data Viewer
Location:
11 D; 11 59.01 cM
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94935301..94967637, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95044475..95076844, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 2 Neighboring gene predicted gene 11513 Neighboring gene predicted gene, 53644 Neighboring gene predicted gene, 53645 Neighboring gene distal-less homeobox 3 Neighboring gene predicted gene, 38659

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendritic spine maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exploration behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leukocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
 
involved_in nephron development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in renal filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in skin development ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone filopodium ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha3-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrin alpha-3
Names
CD49 antigen-like family member C
VLA-3 receptor, alpha 3 subunit
galactoprotein B3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306071.1NP_001293000.1  integrin alpha-3 isoform 2

    See identical proteins and their annotated locations for NP_001293000.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL606480, BC053031, BQ032311
    Consensus CDS
    CCDS83877.1
    UniProtKB/Swiss-Prot
    Q62470
    Related
    ENSMUSP00000103368.2, ENSMUST00000107739.8
    Conserved Domains (2) summary
    smart00191
    Location:337387
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:432887
    Integrin_alpha2; Integrin alpha
  2. NM_001306162.1NP_001293091.1  integrin alpha-3 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001293091.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon the 3' coding region, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC096741, CJ089026
    Consensus CDS
    CCDS83878.1
    UniProtKB/Swiss-Prot
    Q62470
    Related
    ENSMUSP00000113556.2, ENSMUST00000120375.8
    Conserved Domains (2) summary
    smart00191
    Location:368418
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:463918
    Integrin_alpha2; Integrin alpha
  3. NM_013565.3NP_038593.1  integrin alpha-3 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_038593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    BC053031, BQ032311
    Consensus CDS
    CCDS25271.1
    UniProtKB/Swiss-Prot
    Q62470, Q6P6I1
    UniProtKB/TrEMBL
    A0A8C6MZ52
    Related
    ENSMUSP00000001548.8, ENSMUST00000001548.14
    Conserved Domains (2) summary
    smart00191
    Location:368418
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:463918
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    94935301..94967637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532310.5XP_006532373.1  integrin alpha-3 isoform X1

    See identical proteins and their annotated locations for XP_006532373.1

    UniProtKB/Swiss-Prot
    Q62470
    Conserved Domains (2) summary
    smart00191
    Location:368418
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:463918
    Integrin_alpha2; Integrin alpha
  2. XM_006532311.5XP_006532374.1  integrin alpha-3 isoform X2

    See identical proteins and their annotated locations for XP_006532374.1

    UniProtKB/Swiss-Prot
    Q62470, Q6P6I1
    UniProtKB/TrEMBL
    A0A8C6MZ52
    Conserved Domains (2) summary
    smart00191
    Location:368418
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:463918
    Integrin_alpha2; Integrin alpha