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IL6 interleukin 6 [ Homo sapiens (human) ]

Gene ID: 3569, updated on 27-Jan-2020

Summary

Official Symbol
IL6provided by HGNC
Official Full Name
interleukin 6provided by HGNC
Primary source
HGNC:HGNC:6018
See related
Ensembl:ENSG00000136244 MIM:147620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
Summary
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Broad expression in urinary bladder (RPKM 9.7), gall bladder (RPKM 7.1) and 14 other tissues See more
Orthologs

Genomic context

See IL6 in Genome Data Viewer
Location:
7p15.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (22725889..22732002)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (22766766..22771621)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr7.1154 Neighboring gene CRISPRi-validated cis-regulatory element chr7.1155 Neighboring gene IL6 antisense RNA 1 Neighboring gene MT-CYB pseudogene 42 Neighboring gene ribosomal protein S26 pseudogene 32

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cerebral arteriovenous malformation
MedGen: C0917804 OMIM: 108010 GeneReviews: Not available
Compare labs
Diabetes mellitus type 1
MedGen: C0011854 OMIM: 222100 GeneReviews: Not available
Compare labs
Inflammatory bowel disease 1
MedGen: C0678202 OMIM: 266600 GeneReviews: Not available
Compare labs
Kaposi sarcoma, susceptibility to
MedGen: C3538945 OMIM: 148000 GeneReviews: Not available
Compare labs
Rheumatoid arthritis, systemic juvenile
MedGen: C1858558 OMIM: 604302 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
NHGRI GWA Catalog
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.
NHGRI GWA Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection increases basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA, and CEBPG in monocyte derived macrophages PubMed
HIV-1 ADA infection decreases production of CXCL8 (IL8), CCL2 (MCP-1), and IL6 at a basal level or after Fc receptor, complement receptor 3, or bacterial stimulation in primary human macrophages PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 CN54, JRFL, and Ada Env (gp120) upregulates IL-6, CCL2, CCL4, CXCL8, and IL-1b through TLR4 and CCR5 induction in monocyte derived macrophages and hepatic stellate cells because treatment with an anti-TLR4 antibody mitigated the response PubMed
env HIV-1 IIIB Env (gp120) upregulates production of TNF (TNF-a), IL-17A, CCL2 (MCP1), CCL5 (RANTES), IL6, IL10, CXCL8 (IL8), CXCL1 (GRO-a), and CCL1 (I309) in stimulated monocyte derived macrophages PubMed
env Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta PubMed
env Curcumin, a potent and safe anti-inflammatory compound, inhibits HIV-1 gp120-mediated upregulation of the proinflammatory cytokines TNF-alpha and IL-6, and the chemokines IL-8, RANTES, and IP-10 in primary human genital epithelial cells PubMed
env HIV-1 gp120-induced release of IL-6 activates STAT3 in primary human monocyte-derived dendritic cells PubMed
env HIV-1 gp120-induced release of IL-6 is regulated by p38 MAPK, IkappaBalpha, and p65 NF-kappaB activation in primary human monocyte-derived dendritic cells PubMed
env Interaction of HIV-1 gp120 with CCR5 upregulates IL-6 expression in primary human monocyte-derived dendritic cells PubMed
env HIV-1 gp120-induced release of IL-6 and MCP-1 is partially responsible for the impairment of barrier function in human retinal pigment epithelial cells PubMed
env HIV-1 gp120 stimulates monocytes to release TNF-alpha, IL-1 beta, IL-6, and granulocyte-macrophage-CSF, and this effect can be blocked with soluble CD4 PubMed
env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
env HIV-1 gp120-induced expansion of myeloid derived suppressor cells is dependent on the upregulation of IL-6 by gp120 PubMed
env HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and IL-6 dependent STAT3 in immature dentritic cells PubMed
env HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
env HIV-1 gp120 downregulates HIV-1 Nef dependent IL-6 release, which requires the interaction of gp120 with DC-SIGN PubMed
env HIV-1 gp120 induces the release of cytokines MIP-1 alpha, MIP-1 beta, IL-6, IL-10, and TNF-alpha in immature dentritic cells PubMed
env HIV-1 gp120 inhibits CpG-A-induced secretion of TNF-alpha, IL-6, and IP-10 proteins in plasmacytoid dendritic cells and PBMCs PubMed
env HIV-1 gp120 induces a time-dependent IL-6 upregulation by translocating NF-kappaB1 from cytoplasm to nucleus in human astrocyte cells PubMed
env HIV-1 gp120 inhibits TLR9-mediated upregulation of CD83 and the secretion of inflammatory cytokines TNF-alpha and IL-6, and chemokine IP10 in plasmacytoid dendritic cells (pDC) PubMed
env Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK) PubMed
env HIV-1 gp120 activates human brain micro vascular endothelial cells (HBMEC) via CD4 in upregulating ICAM-1 and VCAM-1 expression, IL-6 secretion and increased monocyte transmigration across monolayers PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 induces interleukin-6 production in CD4+ T cells PubMed
env HIV-1 gp140 monomer and trimer induce a time-dependent IL-6 upregulation in human astrocyte cells PubMed
env Chimeric HIV-1 gp140 - CD40L trimers can target and activate dendritic cells to release IL-6, IL-10 and IL-12 PubMed
Envelope transmembrane glycoprotein gp41 env The HIV-1 gp41 transmembrane domain inhibits TLR2-induced activation of ERK1/2, and secretion of TNF-alpha, MCP-1, and IL-6 PubMed
env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IL-6 in peptide-treated PBMCs PubMed
env HIV-1 gp41 induces significant IL-6 production by human monocytic cells; IL-10 inhibits gp41-induced IL-6 production and reduces the expression of IL-6 mRNA PubMed
env Mutations L576A, Q577A, A578G, A582G, V583A, and E584A in the conserved immunosuppressive domain (amino acids 576-589) of HIV-1 gp41 significantly downregulate IL-6 release from human PBMCs PubMed
env PWM, LPS, IFN-gamma and IL-6 can increase HIV-1 gp41 binding to human B cells PubMed
Nef nef HIV-1 Nef induces IL6 and CXCL8 (IL8) expression in a PIK3-PKC dependent, AKT independent manner PubMed
nef HIV-1 Nef induces IL6 and IL8 expression through the NF-kappaB pathway PubMed
nef HIV-1 Nef treatment induces IL6 and IL8 production in SVGA cells and primary human fetal astrocytes PubMed
nef HIV-1 Tat and Nef combination treatment induces release of both IL-6 and IL-8 in human mesenchymal stem cells PubMed
nef The expression of HIV-1 Nef in primary human monocyte-derived macrophages (MDM) induces a significant increase in the concentration of IL-6 PubMed
nef HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
nef HIV-1 gp120 downregulates HIV-1 Nef dependent IL-6 release, which requires the interaction of gp120 with DC-SIGN in immature dentritic cells PubMed
nef HIV-1 Nef synergizes with IL-6 to activate the AKT pathway promoting angiogenesis and tumorigenesis in achicken chorioallantoic membrane model and nude mice PubMed
nef HIV-1 Nef synergizes with IL-6 to upregulate expression of basic fibroblast growth factor and cyclin D1 in NIH3T3-induced tissues PubMed
nef HIV-1 Nef synergizes with IL-6 to enhance vascular tube formation, cell proliferation, VEGF expression, and phosphorylated AKT activation in human umbilical vein endothelial cells PubMed
nef HIV-1 Nef inhibits IFN-gamma-induced apoptosis and upregulates TNF-alpha, IL-6 and MIP-3alpha production by Caco-2 cells while downregulates IL-10 production PubMed
nef Both the myristoylation site and the acidic cluster in HIV-1 Nef are required for the activation of NF-kappaB, which induces upregulation of TNFalpha and IL6 expression PubMed
nef Intracisternal HIV-1 Nef injection upregulates levels of IL-6, TNF-alpha, and IFN-gamma in rat cerebrospinal fluid PubMed
nef HIV-1 Nef expression by immature human and macaque dendritic cells (DCs) upregulates IL-6, IL-12, TNF-alpha, CXCL8, CCL3, and CCL4 release, but without upregulating co-stimulatory and other molecules characteristic of mature DCs PubMed
nef Treatment of human PBMC and PBL with soluble HIV-1 Nef upregulates IL-6 production PubMed
Pr55(Gag) gag MVA-gag induces a significant release of cytokines such as IL-2R, IL-6, IL-8, TNF-alpha, IFN-gamma, MCP-1, MIP-1alpha, MIP-1beta, and RANTES by the infected monocyte-derived dendritic cells in comparison with uninfected cells PubMed
gag Depletion of HIV-specific CD8(+)/IL-10(+) cells from PBMCs leads to upregulation of CD38 on CD14(+) monocytes together with increased IL-6 production in response to HIV-1 gag stimulation PubMed
gag HIV-1 Gag virus-like particles expressed by recombinant baculoviruses activate human PBMC to release IL-6 in a dose and time dependent manner PubMed
gag The Matrix protein of HIV-1 Gag increases IL-6 production in placental mononuclear cells PubMed
Tat tat HIV-1 Tat upregulates IL6 protein expression in human monocytes and monocyte-derived dendritic cells in a TLR4-CD14-MD2 dependent manner PubMed
tat Human microglia cells treated with HIV-1 clade C Tat show more significant upregulation of IL-6 and TNF-alpha, and higher NF-kappaB activation as compared to clade B Tat-treated cells PubMed
tat HIV-1 Tat and Nef combination treatment induces release of both IL-6 and IL-8 in human mesenchymal stem cells PubMed
tat HIV-1 Tat upregulates IL-6 expression in monocytes, astrocytes, microglial cells, human brain endothelial cells, THP-1 and Jurkat T-cells, MC3 B-cells, HeLa, and cells from Kaposi's sarcoma lesions PubMed
tat HIV-1 Tat-induced upregulation of IL-6 in a time-dependent manner involves NF-kappaB and AP-1 transcription factors, activation of the p38 MAPK beta and delta subunits, and PI3K/Akt pathway in astrocytes PubMed
tat Astrocyte cultures treated with morphine and HIV-1 Tat show exaggerated increases in chemokine release, including monocyte chemoattractant protein-1 (MCP-1), RANTES, and IL-6 PubMed
tat Upregulation of IL-6 by HIV-1 Tat in human brain endothelial cells is mediated through activation of protein kinase C (PK-C) and cAMP-dependent protein kinase (PK-A) PubMed
tat HIV-1 Tat inhibits CpG-A-induced secretion of TNF-alpha, IL-6, and IP-10 proteins in plasmacytoid dendritic cells and PBMCs PubMed
tat LRRK2 is involved in HIV-1 Tat-induced cytokine TNF-alpha, IL-6, and MCP-1 expression in microglia cells PubMed
tat HIV-1 Tat significantly decreases TNF-alpha and IL-6 secretion but increases IL-4 levels in human hepatocellular carcinoma cells PubMed
tat HIV-1 Tat downregulates the expression of adiponectin protein and upregulates the expression of IL-6, IL-8, and MCP-1 proteins in human SGBS preadipocytes PubMed
tat Monocytes treated with HIV-1 clade B Tat show significant upregulation of proinflammatory cytokines, IL-6 and TNF-alpha, as compared to clade C Tat-treated cultures PubMed
tat Sulfated polymannuroguluronate (SPMG) significantly reverses HIV-1 Tat-induced release of pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 in THP-1 cells PubMed
tat Ectopic expression of HIV-1 Tat induces the production of human IL-6 (huIL-6) and its receptor (huIL-6Ra) and activates STAT3 signaling; these effects are involved in Tat-mediated activation of Kaposi's sarcoma-associated herpes virus (KSHV) replication PubMed
tat Treatment of T lymphocytes with IL-2, IL-6 and TNFalpha increases CDK9 and cyclin T1 protein levels, suggesting a mechanism for activation of HIV-1 Tat function and reactivation of HIV-1 in CD4+ T lymphocytes harboring a latent provirus PubMed
tat Hydroxyurea and IL-6 synergistically enhance HIV-1 Tat activation of HIV-1 LTR-driven transcription via the Sp1 binding site PubMed
tat HIV-1 Tat protein upregulates expression of IL-6 and IL-8 in human breast cancer cells by an NF-kappaB-dependent pathway PubMed
tat IL-6 and IL-6 receptor are upregulated in human epithelial cells by HIV-1 Tat treatment PubMed
tat HIV-1 Tat upregulates IL-6 expression by transactivating the IL-6 promoter, an effect mediated through enhancement of CAAT enhancer-binding protein (C/EBP; nuclear factor-IL-6) DNA binding activity PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL-8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1) PubMed
vpr HIV-1 Vpr induces IL6 production via activation of MAPK p38 PubMed
vpr HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappaB) in astrocytes PubMed
vpr HIV-1 Vpr upregulation of IL6 involves NFKB1 (NF-kappaB) PubMed
vpr HIV-1 Vpr enhances the secretion of IL6 from human fetal astrocytes PubMed
vpr HIV-1 Vpr upregulates the expression of IL6 mRNA in human fetal astrocytes PubMed
vpr HIV-1 Vpr upregulates the expression of IL6 mRNA in SVGA in a dose-dependent manner PubMed
vpr HIV-1 Vpr upregulates the expression of IL6 mRNA in SVGA astrocytes in a time dependent fashion PubMed
vpr HIV-1 Vpr enhances the secretion of IL6 from SVGA astrocytes in a time dependent fashion PubMed
vpr HIV-1 involves the JUN (AP-1) transcription factor in the induction of IL6 in astrocytes PubMed
vpr HIV-1 Vpr involves the CEBPD (C/EBP-delta) transcription factor in the induction of IL6 in astrocytes PubMed
vpr HIV-1 Vpr-mediated regulation of IL6 involves MAPK8 (Jnk-MAPK8) in astrocytes PubMed
vpr Vpr-mediated upregulation of IL6 involves p38-MAPK11 (beta isoform of p38-MAPK) in astrocytes PubMed
vpr Soluble HIV-1 Vpr induces a markedly reduced expression of IL6 in monocytoid cells PubMed
vpr Concurrent exposure of HIV-1 Vpr with HCV core protein causes higher IL6 expression than HIV-1 Vpr-treated human fetal microglia PubMed
vpr HIV-1 Vpr-induced IL6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88 PubMed
vpr HIV-1 Vpr upregulates IL6 expression in primary macrophages and in A549 cells PubMed
capsid gag Unactivated memory CD4+ T cells infected by HIV-1 in the presence of IL-2 and IL-15 alone or IL-6/IL-7/TNF-alpha combination, upregulate granzyme B and HIV-1 CA production PubMed
gag PLA-p24-loaded human monocyte-derived dendritic cells enhance the secretion of MIP-1beta, IL-6, IL-8, and TNF-alpha in comparison with PLA-loaded cells alone PubMed
matrix gag HIV-1 MA natural variant S75X upregulates the expression of two cyclins D2 and D3, and induces significant release of cytokine IL-6 in both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes PubMed
gag HIV-1 Matrix upregulates IL-6 production in placental mononuclear cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to interleukin-6 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-6 receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
acute-phase response TAS
Traceable Author Statement
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to Gram-negative bacterium TAS
Traceable Author Statement
more info
PubMed 
defense response to Gram-positive bacterium TAS
Traceable Author Statement
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
endocrine pancreas development ISS
Inferred from Sequence or Structural Similarity
more info
 
glucagon secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
hepatic immune response IDA
Inferred from Direct Assay
more info
PubMed 
hepatic immune response TAS
Traceable Author Statement
more info
PubMed 
humoral immune response IC
Inferred by Curator
more info
PubMed 
inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6-mediated signaling pathway TAS
Traceable Author Statement
more info
 
monocyte chemotaxis IC
Inferred by Curator
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of chemokine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of interleukin-1-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of lipid storage NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of neurogenesis TAS
Traceable Author Statement
more info
PubMed 
neuron cellular homeostasis TAS
Traceable Author Statement
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil mediated immunity TAS
Traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JAK-STAT cascade IC
Inferred by Curator
more info
PubMed 
positive regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
NOT positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T-helper 2 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of acute inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic DNA fragmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemokine production NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of immunoglobulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-17 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of leukocyte chemotaxis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neuroinflammatory response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of type B pancreatic cell apoptotic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of angiogenesis IC
Inferred by Curator
more info
PubMed 
regulation of astrocyte activation TAS
Traceable Author Statement
more info
PubMed 
regulation of maintenance of permeability of blood-brain barrier TAS
Traceable Author Statement
more info
PubMed 
regulation of microglial cell activation TAS
Traceable Author Statement
more info
PubMed 
regulation of neuroinflammatory response TAS
Traceable Author Statement
more info
PubMed 
regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
response to glucocorticoid IDA
Inferred from Direct Assay
more info
PubMed 
response to peptidoglycan NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interleukin-6
Names
B-cell differentiation factor
B-cell stimulatory factor 2
CTL differentiation factor
hybridoma growth factor
interferon beta-2
interleukin BSF-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011640.1 RefSeqGene

    Range
    5054..9852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000600.5NP_000591.1  interleukin-6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000591.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK301141, BC015511
    Consensus CDS
    CCDS5375.1
    UniProtKB/Swiss-Prot
    P05231
    UniProtKB/TrEMBL
    B4DVM1, Q75MH2
    Related
    ENSP00000258743.5, ENST00000258743.10
    Conserved Domains (1) summary
    pfam00489
    Location:33211
    IL6; Interleukin-6/G-CSF/MGF family
  2. NM_001318095.2NP_001305024.1  interleukin-6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    CD013918, HY076725
    Consensus CDS
    CCDS83166.1
    UniProtKB/TrEMBL
    B5MC21
    Related
    ENSP00000385043.1, ENST00000407492.5
    Conserved Domains (1) summary
    cl02473
    Location:1135
    IL6; Interleukin-6/G-CSF/MGF family
  3. NM_001371096.1NP_001358025.1  interleukin-6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073072
    Related
    ENSP00000384928.3, ENST00000401630.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    22725889..22732002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515390.2XP_011513692.1  interleukin-6 isoform X2

    See identical proteins and their annotated locations for XP_011513692.1

    UniProtKB/Swiss-Prot
    P05231
    UniProtKB/TrEMBL
    Q75MH2
    Related
    ENSP00000385675.1, ENST00000404625.5
    Conserved Domains (1) summary
    pfam00489
    Location:33211
    IL6; Interleukin-6/G-CSF/MGF family
  2. XM_005249745.5XP_005249802.1  interleukin-6 isoform X1

    See identical proteins and their annotated locations for XP_005249802.1

    UniProtKB/TrEMBL
    B4DNQ5
    Conserved Domains (1) summary
    cl02473
    Location:87212
    IL6; Interleukin-6/G-CSF/MGF family
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