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Il6 interleukin 6 [ Mus musculus (house mouse) ]

Gene ID: 16193, updated on 18-Jan-2022

Summary

Official Symbol
Il6provided by MGI
Official Full Name
interleukin 6provided by MGI
Primary source
MGI:MGI:96559
See related
Ensembl:ENSMUSG00000025746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il-6
Summary
This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Il6 in Genome Data Viewer
Location:
5 B1; 5 15.7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30218112..30224973)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30013114..30019975)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (30339701..30346508)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 10 pseudogene Neighboring gene vacuole membrane protein 1 pseudogene Neighboring gene RIKEN cDNA A230098N10 gene Neighboring gene thymidylate synthase Neighboring gene kinesin family member 2C pseudogene Neighboring gene kinesin superfamily protein 2C pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-6 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T follicular helper cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-helper 17 cell lineage commitment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T-helper 17 cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within acute-phase response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within_positive_effect gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in germinal center B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucagon secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatic immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in liver regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myeloid cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle organ development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of primary miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neutrophil apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of B cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 2 cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell proliferation in bone marrow IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gliogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-21 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucagon secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of interleukin-6 receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of interleukin-6 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of interleukin-6 receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-6
Names
B-cell hybridoma growth factor
interleukin HP-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314054.1NP_001300983.1  interleukin-6 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC112933, AK150440, BC145409
    Consensus CDS
    CCDS84856.1
    UniProtKB/Swiss-Prot
    P08505
    UniProtKB/TrEMBL
    A0A0G2JGF4
    Related
    ENSMUSP00000143544.2, ENSMUST00000195978.5
    Conserved Domains (1) summary
    cl02473
    Location:27157
    IL6; Interleukin-6/G-CSF/MGF family
  2. NM_031168.2NP_112445.1  interleukin-6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_112445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC112933, AK150440
    Consensus CDS
    CCDS19153.1
    UniProtKB/Swiss-Prot
    P08505
    UniProtKB/TrEMBL
    A2RTD1
    Related
    ENSMUSP00000026845.8, ENSMUST00000026845.12
    Conserved Domains (1) summary
    pfam00489
    Location:27210
    IL6; Interleukin-6/G-CSF/MGF family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30218112..30224973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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