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IL3 interleukin 3 [ Homo sapiens (human) ]

Gene ID: 3562, updated on 5-Mar-2024

Summary

Official Symbol
IL3provided by HGNC
Official Full Name
interleukin 3provided by HGNC
Primary source
HGNC:HGNC:6011
See related
Ensembl:ENSG00000164399 MIM:147740; AllianceGenome:HGNC:6011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-3; MCGF; MULTI-CSF
Summary
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IL3 in Genome Data Viewer
Location:
5q31.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132060655..132063204)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (132580524..132583073)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (131396348..131398897)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase long chain family member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16310 Neighboring gene uncharacterized LOC124901062 Neighboring gene ACSL6 antisense RNA 1 Neighboring gene MPRA-validated peak5463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16311 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:131366011-131366190 Neighboring gene uncharacterized LOC105379174 Neighboring gene enhancer-blocking elements downstream of IL3 Neighboring gene origin of replication downstream of CSF2 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:131423316-131423538 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:131429841-131431040 Neighboring gene Sharpr-MPRA regulatory region 12197 Neighboring gene Sharpr-MPRA regulatory region 14284 Neighboring gene colony stimulating factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:131517361-131517888 Neighboring gene NANOG hESC enhancer GRCh37_chr5:131520231-131520732 Neighboring gene Sharpr-MPRA regulatory region 7421 Neighboring gene P4HA2 antisense RNA 1 Neighboring gene prolyl 4-hydroxylase subunit alpha 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
Envelope surface glycoprotein gp160, precursor env The aberrant activation of AP-1 by HIV-1 gp160 in CD4+ T cells is hypothesized to upregulate cytokines containing AP-1 sites (e.g. IL-3 and colony stimulating factor) and lead to T cell unresponsiveness by inhibiting interleukin-2 secretion PubMed
Tat tat HIV-1 Tat specifically associates with IL-3 promoter to upregulate IL-3 expression in T cells PubMed
tat HIV-1 Tat upregulates IL-3 expression in vincristine-treated Kaposi's sarcoma cells, an effect involved in the activation of AKT kinase and that contributes to the anti-apoptotic effect of Tat PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC79398, MGC79399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-3 receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
interleukin-3
Names
P-cell stimulating factor
colony-stimulating factor, multiple
hematopoietic growth factor
mast-cell growth factor
multilineage-colony-stimulating factor
multipotential colony-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000588.4NP_000579.2  interleukin-3 precursor

    See identical proteins and their annotated locations for NP_000579.2

    Status: REVIEWED

    Source sequence(s)
    AC034228
    Consensus CDS
    CCDS4149.1
    UniProtKB/Swiss-Prot
    P08700, Q6GS87
    UniProtKB/TrEMBL
    Q6NZ78, Q6NZ79
    Related
    ENSP00000296870.2, ENST00000296870.3
    Conserved Domains (1) summary
    pfam02059
    Location:27136
    IL3; Interleukin-3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    132060655..132063204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    132580524..132583073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)