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Il3 interleukin 3 [ Mus musculus (house mouse) ]

Gene ID: 16187, updated on 16-Oct-2021

Summary

Official Symbol
Il3provided by MGI
Official Full Name
interleukin 3provided by MGI
Primary source
MGI:MGI:96552
See related
Ensembl:ENSMUSG00000018914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BPA; PSF; HCGF; Il-3; MCGF; Csfmu
Orthologs
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Genomic context

See Il3 in Genome Data Viewer
Location:
11 B1.3; 11 32.13 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54155911..54158105, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54265085..54267279, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54078587..54080781, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12223 Neighboring gene RIKEN cDNA 4933405E24 gene Neighboring gene acyl-CoA-binding protein ACBP pseudogene Neighboring gene colony stimulating factor 2 (granulocyte-macrophage) Neighboring gene predicted gene, 51861 Neighboring gene acyl-CoA synthetase long-chain family member 6 Neighboring gene predicted gene 12224

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables interleukin-3 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables interleukin-3 receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of Janus kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within interleukin-3-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myeloid cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of mast cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mast cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of myeloid leukocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of glycolytic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hypoxia IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-3
Names
P-cell-stimulating factor
hematopoietic growth factor
mast cell growth factor
multipotential colony-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010556.4NP_034686.2  interleukin-3 precursor

    See identical proteins and their annotated locations for NP_034686.2

    Status: VALIDATED

    Source sequence(s)
    AK153634
    Consensus CDS
    CCDS24693.1
    UniProtKB/Swiss-Prot
    P01586
    UniProtKB/TrEMBL
    Q5SX77
    Related
    ENSMUSP00000019058.6, ENSMUST00000019058.6
    Conserved Domains (1) summary
    pfam02059
    Location:35137
    IL3; Interleukin-3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54155911..54158105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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